14.01.2013

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Announcements / Press Releases

Artemisin conference strengthens dialogue within supply chain to maintain malaria medicines on the market [Roll Back Malaria Partners UNITAID, The Global Fund and the World Health Organisation] — (English)
Aligning the global demand for ACT medicines with the supply of artemisinin will be the commanding theme of a two-day international conference, organized with Roll Back Malaria Partners UNITAID, The Global Fund and the World Health Organisation. Launched in 2005, the International Artemisinin Conference convenes yearly the full spectrum of actors involved in the process of producing and delivering medicines for malaria. This year, 140 participants from 21 countries will discuss ways to shorten the lead time between assessing needs for treatment at country level and making the needed medicines available on the market...

PATH Malaria Vaccine Initiative and Inovio Pharmaceuticals partner to accelerate development of malaria vaccines and innovative delivery technologies [PATH press release] — (English)
he PATH Malaria Vaccine Initiative (MVI) and Inovio Pharmaceuticals, Inc. today announced a follow-on collaboration to advance malaria vaccine development and new vaccination delivery technologies...

Abt Associates Awarded New Project to Reduce Malaria in Kenya [Abt Associates] — (English)
IRS Project Builds on Malaria Work Underway in 17 Countries...

L'Initiative 5% sida, tuberculose, paludisme [l'Initiative 5% sida, tuberculose, paludisme] — (French)
Le premier numéro de la lettre d’information et le site internet consacrés à l’Initiative 5% sida, tuberculose, paludisme...

Drive Against Malaria newsflash [DAM] —
January 2013 issue...

UNICEF: Health Manager, P-4, Kinshasa, DRC [UNICEF] — (English)
Application deadline: 22 January 2013...

fhi360: Senior Technical Advisor, Malaria [fhi360] — (English)
FHI 360 is looking for candidates for an important position, Senior Technical Advisor, Malaria in the Integrated Health Sciences Department within the Global Health, Population & Nutrition Group. FHI 360 is looking for an accomplished expert in the field of malaria to help lead the development of a malaria portfolio in support of FHI 360’s strategic plan....

B&M Gates Foundation: Deputy Director, Malaria [BMGF] — (English)
Requisition Number 3719BR...

RBM New York, United States of America: External Relations Officer, P3 [RBM] — (English)
Application deadline: 28 January 2013...

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Articles requiring subscription or registration

Taking a Bite out of Malaria: Controlled Human Malaria Infection by Needle and Syringe [Am J Trop Med Hyg 2013 vol. 88 no. 1 ] — (English)
In this issue of AJTMH, Roestenberg and colleagues report that healthy adults can be infected by the intradermal injection of aseptic, purified, vialed, cryopreserved Plasmodium falciparum sporozoites (PfSPZ Challenge).1 Because of the potential of this “challenge in a bottle” to standardize and dramatically expand the use of controlled human malaria infections (CHMI) for assessment of malaria vaccines, drugs, and diagnostics, and naturally acquired immunity and innate resistance to malaria, this approach to CHMI may well turn out to be one of the major achievements in malaria vaccine research and development of the past half-century...

Response patterns to interactive SMS health education quizzes at two sites in Uganda: a cohort study [Tropical Medicine & International Health, DOI: 10.1111/tmi.12059] — (English)
The use of mobile phones can improve and strengthen (preventive) health care in low- and middle-income countries. We aimed to retrospectively assess the response patterns of participants in free SMS health education quizzes in Uganda...

Maternal Anemia in Pregnancy: Assessing the Effect of Routine Preventive Measures in a Malaria-Endemic Area [Am J Trop Med Hyg 2013 12-0195] — (English)
We investigated the effectiveness of routine preventive measures for anemia in Beninese pregnant women during pregnancy...

N-Cinnamoylated Chloroquine Analogues as Dual-Stage Antimalarial Leads [J. Med. Chem., Article ASAP DOI: 10.1021/jm301654b] — (English)
Now, we report the synthesis and SAR analysis of an expanded series of cinnamic acid derivatives displaying remarkably high activities against both blood- and liver-stage malaria parasites...

Behavioral adaptation of malaria vectors to LLINs: a reply [J Infect Dis. doi:10.1093/infdis/jit012] — (English)
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The impact of host species and vector control measures on the fitness of African malaria vectors [Proc. R. Soc. B 7 March 2013 vol. 280 no. 1754 20122823] — (English)
In Tanzania, we used a semi-field system to test whether the well-documented preferences of the vectors, Anopheles arabiensis and Anopheles gambiae sensu stricto (s.s.) for cattle and humans, respectively, are predicted by the fitness they obtain from host-seeking on these species relative to other available hosts...

Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule [jbc.M112.416347 doi: 10.1074/jbc.M112.416347] — (English)
Here we use biophysical methods to characterize the entire ~300 kDa ectodomain from IT4VAR13, a protein that interacts with the host receptor, intercellular adhesion molecule-1 (ICAM-1)...

Evidence and Implications of Mortality Associated with Acute Plasmodium vivax Malaria [Clin. Microbiol. Rev. January 2013 vol. 26 no. 1 36-57] — (English)
A systematic analysis of the parasite biomass in severely ill patients that includes blood, marrow, and spleen may ultimately explain this historic misunderstanding...

Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin [Vaccine] — (English)
Our results provide important implications for developing effective malaria vaccines and better understanding of acquired immunity against falciparum malaria...

Physiological correlates of ecological divergence along an urbanization gradient: differential tolerance to ammonia among molecular forms of the malaria mosquito Anopheles gambiae [BMC Ecology 2013, 13:1 doi:10.1186/1472-6785-13-1] — (English)
In agreement with expectations based on the pattern of habitat partitioning and exposure to ammonia in larval habitats in Yaounde, the M form showed greater tolerance to ammonia compared to the S form. This trait may be part of the physiological machinery allowing forest populations of the M form to colonize polluted larval habitats, which is at the heart of its niche expansion in densely populated human settlements in Cameroon...

Long term persistence of clonal malaria parasite Plasmodium falciparum lineages in the Colombian Pacific region [BMC Genetics 2013, 14:2 doi:10.1186/1471-2156-14-2] — (English)
We conclude that Colombian populations have several advantages for association studies, because multiple clone infections are uncommon and LD decays over the scale of one or a few genes. However, the extensive population structure and low genotype richness will need to be accounted for when designing and analyzing association studies...

Assessment of Immune Interference, Antagonism, and Diversion following Human Immunization with Biallelic Blood-Stage Malaria Viral-Vectored Vaccines and Controlled Malaria Infection [The Journal of Immunology, 20131201455] — (English)
We also show that controlled infection with 3D7 strain P. falciparum parasites neither boosts existing 3D7-specific T cell responses nor appears to “immune divert” cellular responses toward the Wellcome allele...

Antimalarial pharmacology and therapeutics of atovaquone [J. Antimicrob. Chemother. (2013) doi: 10.1093/jac/dks504] — (English)
It is timely here to review the current knowledge of atovaquone, with the purpose of aiding the decision making of clinicians and drug developers involved in the future use of atovaquone generics or atovaquone derivatives...

Discordance in drug resistance-associated mutation patterns in marker genes of Plasmodium falciparum and Plasmodium knowlesi during coinfections [J. Antimicrob. Chemother. (2013) doi: 10.1093/jac/dks508] — (English)
A larger human population in South-East Asia may be at risk of P. knowlesi infection than reported so far...

Mutation analysis in pfmdr1 and pfmrp1 as potential candidate genes for artemisinin resistance in Plasmodium falciparum clinical isolates 4 years after implementation of artemisinin combination therapy in Iran [Infection, Genetics and Evolution] — (English)
The present study provides information on genetic analysis in multidrug resistance 1 (pfmdr1) (N86Y/S1034C/N1042D/F1226Y/D1246Y) and multidrug resistance protein 1 (pfmrp1) (H191Y/S437A/I876V/F1390I/K1466R) genes that are probably associated with artemisinin resistance as well as chloroquine resistance transporter (pfcrt) 76T in P. falciparum clinical isolates (N = 200) exposed to artemisinin-based combination therapy (ACT) 4 years after its adoption in Iran...

Malaria Diagnosed by Autopsy in a Young Traveler Returning From Uganda: Limitations of Surveillance [Journal of Travel Medicine Volume 20, Issue 1, pages 47–49, January/February 2013] — (English)
Fatal infectious disease acquired during international travel is less likely to be captured through existing surveillance when diagnosis is delayed or missed, especially as autopsy rates decline. Death of a young girl owing to malaria demonstrates needs for increased examination of travel-related deaths through postmortem investigation, autopsy, and expanded surveillance...