25.02.2018

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Announcements / Press Releases

39 African countries estimate the funding they need to meet malaria targets by 2015 [RBM HWG] — (English)
With technical support from Roll Back Malaria partners, 39 African countries began conducting a detailed analysis of their needs and gaps for the period 2013-2016 during a workshop, organised by RBM’s Harmonisation Working Group. This analytical work will provide good foundation for developing proposals for the Global Fund’s new funding model and will feed information about country-driven demand into the Global Fund 2014-2016 replenishment process. Participants shared information on other funding opportunities and mechanisms and helped to identify country technical support needs. The new data will be published in March 2013...

Eliminating Malaria has Longlasting Benefits for Many Countries [JHEPS Press Release] — (English)
A review of malaria elimination conducted by researchers at the Johns Hopkins Malaria Research Institute and other institutions suggests stopping malaria transmission completely has longlasting benefits for many countries and that once eliminated, the disease is unlikely to reemerge over time. Furthermore, total eradication of malaria may not be necessary before countries that eliminate the disease within their own borders can rely on their health systems to control cases. The study is published in the February 22 edition of Science...

Putting malaria on the SHELPH [The University of Nottingham Press Release] — (English)
Experts have disabled a unique member of the signalling proteins which are essential for the development of the malaria parasite...

Stakeholders celebrate 15th anniversary of European Vaccine Initiative [EVI Press Release] — (English)
European Vaccine Initiative marks 15th anniversary with symposium on global health and diseases of poverty...

Malaria Indicator Survey: Basic Documentation for Survey Design and Implementation [malariasurveys.org] — (English)
Update to the Malaria Indicator Survey Package...

Manual for community health workers on pre-referral of rectal artesunate treatment for childhood malaria [TDR, WHO] — (English)
This manual has been developed to help health care practitioners in communities, normally referred to as Community Health Workers (CHWs), to understand how and when to provide rectal artesunate for children seriously ill with malaria, and to help them to refer patients to the nearest facility after this initial treatment...

Program Officer, Malaria Vaccine Initiative [PATH] — (English)
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Articles requiring subscription or registration

The Stability of Malaria Elimination [Science, Vol. 339 no. 6122 pp. 909-910 DOI: 10.1126/science.1229509] — (English)
We identify changes in the epidemiology of malaria when elimination is reached that could explain its stability and discuss how this calls for a reassessment of strategies for eradication...

Implications of temperature variation for malaria parasite development across Africa [Nature Scientific Reports 3, Article number: 1300 doi:10.1038/srep01300] — (English)
Here we examine how parasite development within the mosquito (Extrinsic Incubation Period) is expected to vary over time and space depending on the diurnal temperature range and baseline mean temperature in Kenya and across Africa. Our results show that under cool conditions, the typical approach of using mean monthly temperatures alone to characterize the transmission environment will underestimate parasite development. In contrast, under warmer conditions, the use of mean temperatures will overestimate development...

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin [PNAS February 19, 2013 201217452] — (English)
Here we combine unique in vitro experimental and analytical approaches to mimic in vivo drug exposure in an effort to provide insight into mechanisms of drug resistance...

Risk Factors Associated with Clinical Malaria Episodes in Bangladesh: A Longitudinal Study [Am J Trop Med Hyg 2013 12-0456] — (English)
In this longitudinal study, we used hydrologic, topographic, and socioeconomic risk factors to explain single and multiple malaria infections at individual and household levels...

Dynamics of Anemia in Relation to Parasitic Infections, Micronutrient Status, and Growing Age in South-Central Côte d'Ivoire [J Infect Dis. (2013) doi: 10.1093/infdis/jit066] — (English)
Our results call for effective prevention and control measures targeting parasitic diseases and iron deficiency...

Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum [Cellular Microbiology DOI: 10.1111/cmi.12125] — (English)
We have investigated the organization and development of the exomembrane system that is used for PfEMP1 trafficking. We have investigated the organization and development of the exomembrane system that is used for PfEMP1 trafficking...

Synthesis and Antimalarial Efficacy of Two-Carbon Linked, Artemisinin-Derived, Trioxane Dimers in Combination with Known Antimalarial Drugs [J. Med. Chem., Just Accepted Manuscript DOI: 10.1021/jm400058j] — (English)
Here we report, for the first time, synthesis of a series of two-carbon linked artemisinin-derived dimers, their unique structural features, and demonstration of their antimalarial efficacy via single oral dose administration in two in vivo experiments...

A high prevalence of asymptomatic malaria in a tribal population of Eastern India [JCM.03437-12] — (English)
The systematic identification and treatment of asymptomatic infection should reduce the parasite reservoir, if this pool is greatly reduced, it will have an impact on disease transmission...

Effects of the combined artesunate and mefloquine antimalarial drugs on rat embryos [Hum Exp Toxicol 0960327113475678] — (English)
To evaluate the effects of isolated and combined artesunate (AS)/mefloquine (MQ) on embryo rats, pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9–11 post coitum (pc)...

Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood stage development [Cellular Microbiology DOI: 10.1111/cmi.12124] — (English)
We found that Py-ICP was refractory to targeted gene deletion indicating an essential function during asexual blood stage replication, but significant down-regulation of ICP using a regulated system did not impact blood stage growth...

Artemether and lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa [Expert Opinion on Pharmacotherapy] — (English)
AL is an important antimalarial that will play a major role as countries move towards the elimination of malaria. Further advances in best practice of ACT use will come through strategies to prolong the longevity of ACTs, improved access to ACTs, new data on the use of ACTs in pregnancy, asymptomatic patients and novel paediatric formulations...

Coping with time and space in modelling malaria incidence: a comparison of survival and count regression models [Statistics in Medicine DOI: 10.1002/sim.5752] — (English)
To study the effect of a mega hydropower dam in southwest Ethiopia on malaria incidence, we have set up a longitudinal study...

Haptoglobin phenotypes and iron status in children living in a malaria endemic area of Kenyan coast [Acta Tropica] — (English)
This study shows that the presence of malaria may complicate the interpretation of iron status in children based on their Hp-phenotypes...

Overcoming health systems barriers to successful malaria treatment [Trends in Parasitology, 10.1016/j.pt.2013.01.005] — (English)
The success of malaria control programmes is recognised to be handicapped by the capacity of the health system to deliver interventions such as first-line treatment at optimal coverage and quality. Traditional approaches to strengthening the health system such as staff training have had a less sustained impact than hoped. However, novel strategies including the use of mobile phones to ease stockouts, task-shifting to community health workers, and inclusion of the informal sector appear more promising. As global health funding slows, it is critical to better understand how to deliver a proven intervention most effectively through the existing system...

Placental Malaria: From Infection to Malfunction [Cell Host & Microbe, Volume 13, Issue 2, 125-127, 10.1016/j.chom.2013.01.014] — (English)
Malaria during pregnancy is a major factor in infant morbidity and mortality. In this issue of Cell Host and Microbe, Conroy et al., 2013 propose that C5a, a product of complement cascade activation, counteracts the placental vascular remodeling response induced by Plasmodium infection and contributes to fetal growth restriction...

Molecular determinants of binding to the Plasmodium subtilisin-like protease 1 [J. Chem. Inf. Model., DOI: 10.1021/ci300581z] — (English)
In order to provide a detailed understanding of the origin of binding determinants of PfSUB1 substrates, we performed molecular dynamics simulations in combination with MM-GBSA free energy calculations using a homology model of PfSUB1 in complex with different substrate peptides...