11.03.2018

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Announcements / Press Releases

UN Secretary General appoints Ray Chambers to secure financing for the health-related MDGs [RBM] — (English)
The Roll Back Malaria Partnership applauds the UN Secretary General’s decision to appoint Ray Chambers of the United States as the Special Envoy for Malaria and for the Financing of the Health-Related Millennium Development Goals (MDGs)...

Global Fund Praises Choice of Ray Chambers as Special Envoy [The Global Fund Announcement] — (English)
Mark Dybul, Executive Director of the Global Fund to Fight AIDS, Tuberculosis and Malaria, today praised the appointment of Ray Chambers as the United Nations Secretary General's first Special Envoy for Financing of the Health Related Millennium Development Goals...

Ban tasks UN malaria envoy with boosting funds for health-related development goals [UN News Centre] — (English)
Secretary-General Ban Ki-moon has tasked Ray Chambers, who has served as his Special Envoy for Malaria since 2008, with promoting and securing greater investment to achieve the health-related targets within the Millennium Development Goals (MDGs)...

Global Fund Launches New Funding Model [The Global Fund News Release] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria today launched a new funding model that allows it to invest more strategically, achieve greater impact, and engage implementers and partners more effectively...

Novavax, CPLB and ICGEB Collaboration Honored for Malaria Vaccine Progress at Vaccine World Summit India 2013 [Novavax Press Release] — (English)
Novavax, Inc. today announced that its collaboration to develop a novel malaria vaccine in India has been honored by the Vaccine World Summit India 2013 conference for having the “Most Promising Vaccine for Emerging Diseases in India.”...

Abattis Participates In Project On A Whole Plant Therapeutic For Treating Malaria And Other Diseases And Reducing Drug Resistance [Abattis Bioceuticals Corp. Press Release] — (English)
Abattis Bioceuticals Corp. is pleased to announce its participation in a research project led by Pamela Weathers, Professor of Biology and Biotechnology at Worcester Polytechnic Institute (WPI) in Worcester, Mass. that is investigating a whole plant therapeutic for treating malaria and other diseases, one that may also reduce drug resistance”...

MMV: Project Director, Product Development [MMV] — (English)
Application deadline: 13 March 2013...

The Global Health Group at the University of California, San Francisco: Opportunity for a Consultancy Landscape Analysis: Identifying Innovative Financing Mechanisms for Malaria Elimination [GHG] — (English)
Application deadline: 15 March 2013...

ACT Consortium: Technical Communications Officer [ACT Consortium] — (English)
Application deadline: 22 March 2013...

B&M Gates Foundation: Deputy Director, Malaria [BMGF] — (English)
Requisition Number 3719BR...

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Articles requiring subscription or registration

Malaria parasite's survival trick unveiled [Nature India doi:10.1038/nindia.2013.33] — (English)
The malaria parasite Plasmodium falciparum survives in the blood of humans by degrading hemoglobin into hemozoin. How the deadly parasite spins this trick has been an enigma for malaria researchers...

Assessment of the RTS,S/AS01 malaria vaccine [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(13)70047-1] — (English)
The most advanced malaria vaccine candidate is RTS,S/AS01, which is directed against Plasmodium falciparum malaria. This vaccine is being assessed in a phase 3 trial at 11 sites in seven countries in sub-Saharan Africa...

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(13)70005-7] — (English)
The efficacy of RTS,S/AS01 as a vaccine for malaria is being tested in a phase 3 clinical trial. Early results show significant, albeit partial, protection against clinical malaria and severe malaria. To ascertain variations in vaccine efficacy according to covariates such as transmission intensity, choice of adjuvant, age at vaccination, and bednet use, we did an individual-participant pooled analysis of phase 2 clinical data...

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum [PNAS] — (English)
Our results show that falcipain 2 and heme detoxification protein associate with each other to efficiently convert Hb to Hz...

Impact of Indoor Residual Spraying of Lambdacyhalothrin on Malaria Prevalence and Anemia in an Epidemic-Prone District of Muleba, North-Western Tanzania [Am J Trop Med Hyg 2013 12-0412] — (English)
Malaria parasitological baseline and two cross-sectional follow-up surveys were conducted in villages under the IRS program and those not under IRS to assess the impact of IRS intervention...

Efficacy of Chloroquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Honduras [Am J Trop Med Hyg 2013 12-0671] — (English)
This finding shows that CQ remains highly efficacious for the treatment of uncomplicated P. falciparum malaria in Gracias a Dios, Honduras...

The Effect of Indoor Residual Spraying on Malaria and Anemia in a High-Transmission Area of Northern Uganda [Am J Trop Med Hyg 2013 12-0747] — (English)
Carefully managed IRS can significantly reduce malaria burden in high-transmission settings...

Primaquine for Radical Cure of Plasmodium vivax and Plasmodium ovale Malaria: An Observational Survey (2008–2010) [Journal of Travel Medicine Volume 20, Issue 2, pages 134–136, March/April 2013] — (English)
Since 2008, the French guidelines have promoted the systematic use of 30 mg/day of primaquine for the radical cure of Plasmodium vivax and Plamodium ovale infections. We observed three relapses in 10 patients with P vivax acquired in French Guiana. No relapses were seen in West African P ovale patients...

Transfusion-transmitted malaria in Ghana [Clin Infect Dis. (2013) doi: 10.1093/cid/cit130] — (English)
This study aimed to establish the incidence of TTM and identify a suitable screening test...

Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial [J Infect Dis. (2013) doi: 10.1093/infdis/jit077] — (English)
While DP is associated with a longer prophylactic time after treatment, gametocyte carriage and malaria transmission to mosquitoes are lower after AL...

Population genetic structure and polymorphism analysis of gene encoding apical membrane antigen-1 (AMA-1) of Iranian Plasmodium vivax wild isolates [Acta Tropica] — (English)
In the present study, polymorphism of pvama-1 among Iranian isolates was investigated to generate useful information on this vaccine candidate antigen, which is required for the rational design of a vaccine against P. vivax...

Primaquine for Radical Cure of Plasmodium vivax and Plasmodium ovale Malaria: An Observational Survey (2008–2010) [Journal of Travel Medicine Volume 20, Issue 2, pages 134–136, March/April 2013] — (English)
...

Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion [Cellular Microbiology DOI: 10.1111/cmi.12132] — (English)
We describe the core architectural features of invasion and identify fusion between rhoptries at the commencement of invasion as a hitherto overlooked event that likely provides a critical step that initiates entry...

A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes [Cellular Microbiology DOI: 10.1111/cmi.12131] — (English)
We show here that egress of the male gametocyte depends on the function of a perforin-like protein, PPLP2...

PvMSP1P, merozoite surface protein 1 paralog, is a novel erythrocyte-binding ligand of Plasmodium vivax [IAI.01117-12] — (English)
We studied the naturally acquired immune response against each fragment of recombinant PvMSP1P and the potential binding ability of each fragment to erythrocytes...

Reticulocytes: Plasmodium vivax target cells [Biology of the Cell DOI: 10.1111/boc.201200093] — (English)
This review describes the most recent studies related to obtaining reticulocytes and discusses approaches which could contribute towards knowledge regarding molecular interactions between target cell proteins and their main infective agent, P. vivax...

Staining-free malaria diagnostics by multispectral and multimodality light-emitting-diode microscopy [Journal of Biomedical Optics] — (English)
We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope...

The specific, reversible JNK inhibitor SP600125 improves survivability and attenuates neuronal cell death in experimental cerebral malaria (ECM) [Parasitology Research] — (English)
We evaluated the effect of SP600125 treatment on the survival of Plasmodium berghei ANKA (PbA)-infected C57BL/6J mice...

Association between serum zinc concentration and the Plasmodium falciparum antibody titer among rural villagers of Attapeu Province, Lao People's Democratic Republic [Acta Tropica] — (English)
We investigated an association between the anti-Plasmodium falciparum (Pf) antibody (immunoglobulin G) titer and serum zinc concentration among villagers in rural areas of the Lao People's Democratic Republic..

Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity [J Infect Dis. (2013) doi: 10.1093/infdis/jit082] — (English)
Parasite clearance in response to artesunate is faster in Mali than in southeast Asia. IgG responses to parasitized RBCs shorten half-life and may influence this parameter in areas where age is not an adequate surrogate of immunity, and correlates of parasite-clearing immunity have not been identified...

Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum [J Infect Dis. (2013) doi: 10.1093/infdis/jit083] — (English)
Here, we aimed to identify clinically relevant antibody responses taking into consideration variations in parasite exposure and HIV infection...

Identifying permethrin resistance loci in malaria vectors by genetic mapping [Parasitology DOI: http://dx.doi.org/10.1017/S0031182013000024 ] — (English)
In this study, we report the results from genetic mapping of pyrethroid resistance in three isofemale pedigrees established from wild-caught female A. gambiae s.s. mosquitoes from Benin...