18.03.2018

Read this issue and previous issues online.

Follow us on:
Follow us on Twitter  Follow us on Facebook  Follow us on Flickr Follow us on YouTube   Follow us on LinkedIn

Announcements / Press Releases

World Malaria Day is only a month away [RBM] — (English)
On World Malaria Day each year, Roll Back Malaria (RBM) partner organisations unite around a common theme. Invest in the future: defeat malaria is the theme partners chose for the next three years to call attention to #thebigpush needed to reach the 2015 Millennium Development Goals and defeat malaria in the future...

APMEN V Annual Meeting: Advancing the Agenda for Malaria Elimination in the Asia Pacific [APMEN Media Release] — (English)
APMEN held the fifth annual Business and Technical meeting in Bali, Indonesia (4 - 7 March, 2013)...

Quinolones: breathing new life into an old class of compounds to tackle malaria [MMV News] — (English)
One compound shows potential to cure malaria and block transmission at low doses...

NIH-Supported Researchers Identify New Class of Malaria Compounds [NIH News] — (English)
A group of researchers from 16 institutions around the world has identified a new class of anti-malarial compounds that target multiple stages of the malaria parasite’s life cycle...

CONSULTANT - DEVELOPING A MULTI-SECTORAL APPROACH TO MALARIA [UNDP] — (English)
Application deadline: 1 April 2013...

Malaria Consortium: South Sudan Country Director [Malaria Consortium] — (English)
Application deadline: 7 April 2013...

B&M Gates Foundation: Deputy Director, Malaria [BMGF] — (English)
Requisition Number 3719BR...

25.03.2013

{title} [{articlesource}] — ({language})
{description}...

24.03.2013

{title} [{articlesource}] — ({language})
{description}...

23.03.2013

{title} [{articlesource}] — ({language})
{description}...

22.03.2013

{title} [{articlesource}] — ({language})
{description}...

21.03.2013

{title} [{articlesource}] — ({language})
{description}...

20.03.2013

{title} [{articlesource}] — ({language})
{description}...

19.03.2013

{title} [{articlesource}] — ({language})
{description}...

Articles requiring subscription or registration

Articles requiring subscription or registration

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure [NEJM doi/10.1056/NEJMoa1207564] — (English)
The candidate malaria vaccine RTS,S/AS01E has entered phase 3 trials, but data on long-term outcomes are limited...

US Department of Defense contributions to malaria surveillance [he Lancet Infectious Diseases, Volume 13, Issue 4, Pages 293 - 294, April 2013 doi:10.1016/S1473-3099(13)70065] — (English)
The US DoD has been actively involved in the study of malaria drug-resistance for several decades, and has supported many antimalarial resistance studies worldwide. The US DoD has played an active part in artemisinin-resistance surveillance in southeast Asia after the recommendation of artemisinin combination therapies (ACT) as first-line antimalarial treatments by WHO in 2006...

Weighing for results: assessing the effect of IPTp — Authors' reply [he Lancet Infectious Diseases, Volume 13, Issue 4, Pages 292 - 293, April 2013 doi:10.1016/S1473-3099(13)70060-4] — (English)
Julie Gutman and colleagues argue that our meta-analysis1 results from 32 national surveys are likely to underestimate the benefit of reduced low birthweight and neonatal mortality associated with intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine—pyrimethamine and insecticide-treated mosquito nets (ITNs)...

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug [Sci Transl Med 20 March 2013: Vol. 5, Issue 177, p. 177ra37 Sci. Transl. Med. DOI: 10.1126/scitranslmed.3005029] — (English)
The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite’s life cycle, thus impacting prevention, treatment, and transmission of the disease. The 4(1H)-quinolone-3-diarylethers are selective potent inhibitors of the parasite’s mitochondrial cytochrome bc1 complex. These compounds are highly active against the human malaria parasites Plasmodium falciparum and Plasmodium vivax. They target both the liver and blood stages of the parasite as well as the forms that are crucial for disease transmission, that is, the gametocytes, the zygote, the ookinete, and the oocyst. Selected as a preclinical candidate, ELQ-300 has good oral bioavailability at efficacious doses in mice, is metabolically stable, and is highly active in blocking transmission in rodent models of malaria. Given its predicted low dose in patients and its predicted long half-life, ELQ-300 has potential as a new drug for the treatment, prevention, and, ultimately, eradication of human malaria...

A model of parity-dependent immunity to placental malaria [Nature Communications 4, Article number: 1609 doi:10.1038/ncomms2605] — (English)
Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration...

Complex nature of malaria parasite hemoglobin degredation [PNAS 2013 ; published ahead of print March 19, 2013] — (English)
By Daniel E. Goldberg...

Plasmodium vivax Isolates from Cambodia and Thailand Show High Genetic Complexity and Distinct Patterns of P. vivax Multidrug Resistance Gene 1 (pvmdr1) Polymorphisms [Am J Trop Med Hyg 2013 12-0701] — (English)
We compared P. vivax genetic complexity and antimalarial resistance patterns in the two countries...

Association between Prevalence of Chloroquine Resistance and Unusual Mutation in pfmdr-I and pfcrt Genes in India [Am J Trop Med Hyg 2013 11-0795] — (English)
This study deals with the underlying causes of failure of chloroquine in the treatment of Plasmodium falciparum infection in some malaria-endemic regions of India...

Evaluation of Recombinant Plasmodium knowlesi Merozoite Surface Protein-133 for Detection of Human Malaria [Am J Trop Med Hyg 2013 12-0250] — (English)
lasmodium knowlesi is now known as the fifth Plasmodium species that can cause human malaria. The Plasmodium merozoite surface protein (MSP) has been reported to be potential target for vaccination and diagnosis of malaria...

Imported malaria: a possible threat to the elimination of malaria from Sri Lanka? [Tropical Medicine & International Health DOI: 10.1111/tmi.12097] — (English)
The aim of the article is to discuss epidemiological aspects of imported malaria and the potential impact of imported malaria cases reported in Sri Lanka 2008–2011 in terms of a possible resurgence of the disease....

Anti-Pfs25 Human Plasma Reduces Transmission of Diverse Plasmodium falciparum Isolates by Direct Membrane Feeding Assays [IAI.00016-13] — (English)
Pfs25 is a leading candidate for a malaria transmission blocking vaccine who's potential has been demonstrated in a Phase 1 trial with recombinant Pfs25 formulated with Montanide® ISA51. Because of limited sequence polymorphism, the anti-Pfs25 antibodies induced by this vaccine are likely to have transmission blocking or reducing activity against most, if not all, field isolates. To test this hypothesis, we evaluated transmission blocking activities by membrane feeding assay of anti-Pfs25 plasma from the Pfs25/ISA51 Phase I trial, against P. falciparum parasites from patients in two different geographical regions of the world, Thailand and Burkina Faso...

Modulation of the immune-inflammatory responses by Plasmodium falciparum schizont extracts: role of myeloid dendritic cells in effector and regulatory functions of CD4+ lymphocytes [IAI.01226-12] — (English)
To evaluate the role of dendritic cells (DC) in the balance of parasite-induced inflammatory-anti inflammatory mechanisms we studied the activity of monocyte-derived dendritic cells (MDDC), previously exposed to soluble extracts of Plasmodium falciparum-infected red blood cells (PfSE), in the differentiation of CD4 cells isolated from donors never exposed to malaria infection...

Plasmodium coatneyi in rhesus macaques replicates the multi-systemic dysfunction of severe malaria in humans [IAI.00027-13] — (English)
Here we systematically investigate infections with Plasmodium coatneyi, a simian malaria parasite that closely mimics the biological characteristics of P. falciparum, and develop baseline data and protocols for studying erythrocyte turnover and severe malaria in greater depth...

Enemy in the blood: Malaria, environment, and development in Argentina [Global Public Health: An International Journal for Research, Policy and Practice] — (English)
Book review...

Novel Plasmodium falciparum Maurer's clefts protein families implicated in the release of infectious merozoites [Molecular Microbiology DOI: 10.1111/mmi.12193] — (English)
We report here the characterization of three new P. falciparum multigene families organized in 9 highly conserved clusters with the Pfmc-2tm genes in the subtelomeric regions of parasite's chromosomes and expressed at early trophozoite stages..

Validation of a multi-residue method to determine deltamethrin and alpha-cypermethrin in mosquito nets by gas chromatography with electron capture detection (GC-μECD) [Parasites & Vectors 2013, 6:77 doi:10.1186/1756-3305-6-77] — (English)
The aim of this study was to optimize a short time extraction method for deltamethrin and alpha-cypermethrin from coated and incorporated mosquito nets and also to detect both insecticides in one analytical run, using gas chromatography with electron capture detection (GC-μECD)...

A shift from Indoor Residual Spraying (IRS) with bendiocarb to Long-Lasting Insecticidal (mosquito) Nets (LLINs) associated with changes in malaria transmission indicators in pyrethroid resistance areas in Benin [arasites & Vectors 2013, 6:73 doi:10.1186/1756-3305-6-73] — (English)
Indoor residual spraying (IRS) was implemented in the department of Oueme-Plateau, southern Benin, in 2008 and withdrawn in 2011, when long lasting insecticidal nets (LLINs) were distributed to the communities that were previously targeted by IRS. Did the LLIN strategy provide a better level of protection against malaria transmission than IRS?...

Advantages and limitations of commercially available electrocuting grids for studying mosquito behaviour [Parasites & Vectors 2013, 6:53 doi:10.1186/1756-3305-6-53] — (English)
Mosquito feeding behaviour plays a major role in determining malaria transmission intensity and the impact of specific prevention measures. Human Landing Catch (HLC) is currently the only method that can directly and consistently measure the biting rates of anthropophagic mosquitoes, both indoors and outdoors. However, this method exposes the participant to mosquito-borne pathogens, therefore new exposure-free methods are needed to replace it...

Modelling the risk of being bitten by malaria vectors in a vector control area in southern Benin, west Africa [Parasites & Vectors 2013, 6:71 doi:10.1186/1756-3305-6-71] — (English)
Here, we analyzed the spatio-temporal risk of the contact between humans and the sympatric An. funestus and both M and S molecular forms of An. gambiae s.s. in an area of Benin with high coverage of vector control measures with an unprecedented level of resolution...

gSG6-P1 salivary biomarker discriminates micro-geographical heterogeneity of human exposure to Anopheles bites in low and seasonal malaria areas [Parasites & Vectors 2013, 6:68 doi:10.1186/1756-3305-6-68] — (English)
In this study, we investigated whether the human antibody (Ab) response to Anopheles salivary gSG6-P1 peptide, known as a biomarker of Anopheles exposure, could be a sensitive and reliable tool for discriminating human exposure to Anopheles bites in area of low and seasonal malaria transmission...

Abundance, behavior and entomological inoculation rates of anthropophilic anophelines from a primary Colombian malaria endemic area [Parasites & Vectors 2013, 6:61 doi:10.1186/1756-3305-6-61] — (English)
Malaria vector incrimination and the characterization of entomological parameters will allow for a better understanding of malaria transmission dynamics and the design of effective vector control strategies for this region...

Natural infection in anopheline species and its implications for autochthonous malaria in the Atlantic forest in Brazil [Parasites & Vectors 2013, 6:58 doi:10.1186/1756-3305-6-58] — (English)
A descriptive study was carried out in an area of the Atlantic Forest with autochthonous malaria in the Parelheiros subdistrict on the periphery of the municipality of São Paulo to identify anopheline fauna and anophelines naturally infected with Plasmodium as well as to discuss their role in this peculiar epidemiological context...

A need for better housing to further reduce indoor malaria transmission in areas with high bed net coverage [Parasites & Vectors 2013, 6:57 doi:10.1186/1756-3305-6-57] — (English)
This study was conducted in a high transmission setting and presents further evidence about the association between specific house characteristics and the abundance of endophilic malaria vectors...

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials [J. Med. Chem., Article ASAP DOI: 10.1021/jm400009c] — (English)
We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally...

SPATIAL PATTERNS OF AVIAN MALARIA PREVALENCE IN ZONOTRICHIA CAPENSIS ON THE WESTERN SLOPE OF THE PERUVIAN ANDES [J Parasitol.] — (English)
We surveyed avian malaria infections in Rufous-collared sparrows (Zonotrichia capensis) across replicated altitudinal and latitudinal transects along the western slope of the Peruvian Andes to assess geographic patterns of prevalence...

HUMAN RESOURCE CAPACITY TO EFFECTIVELY IMPLEMENT MALARIA ELIMINATION: A POLICY BRIEF FOR ETHIOPIA [nternational Journal of Technology Assessment in Health Care] — (English)
The aim of this study was to investigate malaria elimination in Ethiopia. Ethiopia has planned to eliminate malaria by 2015 in areas of unstable malaria transmission and in the entire country by 2020. However, there is a shortage and maldistribution of the health workforce in general and malaria experts in particular. Training, motivating, and retaining the health workforce involved in malaria control is one strategy to address the shortage and maldistribution of the health workforce to achieve the goal of elimination...

Recent advances in marine drug research [Biotechnology Advances — (English)
Structures and properties of promising marine anti-cancer, anti-inflammation and anti-infectious (HIV, HSV, malaria, leishmania) compounds reported during 2008–2011 are discussed...