15.04.2018

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Announcements / Press Releases

RBM Ambassador Yvonne Chaka Chaka calls for a fully replenished Global Fund [RBM] — (English)
As the Global Fund's first replenishment meeting draws to a close, Roll Back Malaria Ambassador Yvonne Chaka Chaka, calls on international donors to accelerate the fight against the three global diseases – HIV/AIDS, tuberculosis and malaria. From the digital pages of the "Big Push," Chaka Chaka also urges African leaders to "make good on promises to invest more in the health of their people"...

Artist Karen Mok becomes RBM Champion in Asia [RBM press release] — (English)
Renowned singer and actress Karen Mok announced today that she intends to lend her celebrity voice to the global fight against malaria. During a press conference held alongside the World Health Summit Regional Meeting – Asia (WHSRMA) in Singapore, Ms. Mok was named a Roll Back Malaria (RBM) Partnership Champion. She will help ensure that malaria remains a priority on key international development agendas, particularly in her native Asia...

UN-backed fund needs $87 billion to fight HIV/AIDS, tuberculosis and malaria [UN News Centre] — (English)
United Nations representatives and international donors today wrapped up discussions on how to finance an estimated $87 billion needed by the UN-backed Global Fund to bring under control the global threat posed by HIV/AIDS, tuberculosis and malaria during the 2014-2016 period...

Global Fund Targets $15 Billion to Effectively Fight AIDS, TB and Malaria [The Global Fund press release] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria announced a goal of raising US$15 billion so that it can effectively support countries in fighting these three infectious diseases in the 2014-2016 period...

AMYRIS SCIENTISTS DESCRIBE BREAKTHROUGH IN DEVELOPMENT OF ANTI-MALARIAL DRUG PRECURSOR [Amyris news release] — (English)
Scientists from Amyris published in the journal Nature the details of a major breakthrough in the field of synthetic biology that allows for the production of a key precursor to Artemisinin, the key ingredient in the world’s most effective and preferred drug in combating malaria. Earlier today, pharmaceutical company Sanofi announced the launch of large-scale industrial production of Artemisinin utilizing Amyris designed strains...

Sanofi and PATH announce the Launch of Large-scale Production of Semisynthetic Artemisinin against Malaria [Sanofi and PATH / One World Health press release] — (English)
Sanofi and PATH’s Drug Development program, established through an affiliation with OneWorld Health, today announced the launch of the large-scale production line of semisynthetic artemisinin at Sanofi’s Garessio site in Italy...

HWG Resource Mobilization Workstream Teleconference [RBM HWG] — (English)
As of 26 March 2013...

RBM Partnership Programmatic Gap Analysis [RBM HWG] — (English)
The gap analysis tools helps countries to compile information on their programmatic needs and gaps across all interventions for a period of several years. The current tool helps countries to summarize their needs and gaps from 2013-2016. The tool is for summary purposes only and is not a quantification tool...

Analyse des écarts programmatiques [RBM HWG] — (French)
Une analyse exhaustive des carences programmatiques souligne l’ensemble des exigences programmatiques qu’il convient de respecter pour assurer la mise en œuvre complète du plan stratégique d’un programme national de lutte contre le paludisme...

2012 Roadmap Implementation in 47 malaria endemic countries in Africa [RBM] — (English)
Analytical update...

WWARN's 6th Newsletter (March issue) [WWARN] — (English)
Learn more about WWARN new in vitro analysis and reporting tool; a breakthrough in identifying antimalarial drug resistance; and a regional approach to antimalarial drug efficacy surveillance...
Lettre d’information - mars 2013 - en français


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Articles requiring subscription or registration

High-level semi-synthetic production of the potent antimalarial artemisinin [Nature (2013) doi:10.1038/nature12051] — (English)
Here we use synthetic biology to develop strains of Saccharomyces cerevisiae (baker’s yeast) for high-yielding biological production of artemisinic acid, a precursor of artemisinin. Previous attempts to produce commercially relevant concentrations of artemisinic acid were unsuccessful, allowing production of only 1.6 grams per litre of artemisinic acid. Here we demonstrate the complete biosynthetic pathway, including the discovery of a plant dehydrogenase and a second cytochrome that provide an efficient biosynthetic route to artemisinic acid, with fermentation titres of 25 grams per litre of artemisinic acid...

Intra-specific diversity of Serratia marcescens in Anopheles mosquito midgut defines Plasmodium transmission capacity [Scientific Reports 3, Article number: 1641 doi:10.1038/srep01641] — (English)
To understand the response mechanisms within the midgut environment, including those influenced by resident microbiota against Plasmodium, we focus on a midgut bacteria species' intra-specific variation that confers diversity to the mosquito's competency for malaria transmission...

Plasmodium falciparum-like parasites infecting wild apes in southern Cameroon do not represent a recurrent source of human malaria [ PNAS, pnas.1305201110 ] — (English)
Here, we used Plasmodium species-specific PCR, single-genome amplification, and 454 sequencing to screen humans from remote areas of southern Cameroon for ape Laverania infections...

Comparison of modelling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection [J Infect Dis. (2013) doi: 10.1093/infdis/jit156] — (English)
We used qPCR data from 267 Plasmodium falciparum infections to compare linear, sine-wave, and normal-cumulative-density-function models. We find that the parameters estimated by these models are closely correlated, and their predictive accuracy for omitted data points was similar. We propose that future studies include the linear model...

Histopathologies, Immunolocalization, and a Glycan Binding Screen Provide Insights into Plasmodium falciparum Interactions with the Human Placenta [Biology of Reproduction April 10, 2013 biolreprod.112.106195] — (English)
Here, we investigated mechanisms of infected erythrocyte sequestration in relationship to the microanatomy of the maternal-fetal interface...

Plasmodium rhoptry proteins: why order is important [Trends in Parasitology, 10.1016/j.pt.2013.03.003] — (English)
Here we discuss recent work that has advanced our knowledge of rhoptry protein trafficking and function, and highlight areas of research that require further investigation...

Evaluation of alternative mosquito sampling methods for malaria vectors in Lowland South - East Zambia [Parasites & Vectors 2013, 6:91 doi:10.1186/1756-3305-6-91] — (English)
Human landing catch (HLC) has been traditionally regarded as a gold standard method for surveying human exposure to mosquito bites. However, due to the risk of human participant exposure to mosquito-borne parasites and viruses, a variety of alternative, exposure-free trapping methods were compared in lowland, south-east Zambia...

Molecular characterization of the Carboxypeptidase B1 of Anopheles stephensi and its evaluation as a target for transmission-blocking vaccine (TBV) [ IAI.01331-12 doi: 10.1128/​IAI.01331-12] — (English)
In this study, carboxypeptidase B1 of An. stephensi was characterized by genomic and proteomic approaches...

Online biomedical resources for malaria-related red cell disorders [Human Mutation, DOI: 10.1002/humu.22330] — (English)
Here, we review the content of these databases, most of which focus on genetic diversity, and we describe a new epidemiological resource developed by the Malaria Atlas Project (MAP)...

Malarial Kinases: Novel Targets for In Silico Approaches to Drug Discovery [Methods in Molecular Biology Volume 993, 2013, pp 205-229] — (English)
This review focuses on in silico methods that have been used for the evaluation of potential antimalarials and the Plasmodium kinases that could be explored using these techniques...

In Silico Models for Drug Resistance [Methods in Molecular Biology Volume 993, 2013, pp 39-65] — (English)
As a case study, we investigated the response of the malaria parasite Plasmodium falciparum to chloroquine and tetracycline treatments...

As a case study, we investigated the response of the malaria parasite Plasmodium falciparum to chloroquine and tetracycline treatments [J Infect Dis. (2013) doi: 10.1093/infdis/jit151] — (English)
Here we showed that vaccination of macaques with recombinant(r) Listeria ΔactA prfA* expressing SHIV gag and env elicited Gag and Env-specific T-cell responses, and protected against life-threatening SHIV-related malaria after SHIV/P. fragile co-infection...

Malaria control under unstable dynamics: Reactive vs. climate-based strategies [Acta Tropica] — (English)
We show that this type of feedback mechanism in control strategies can generate transient cycles in malaria even in the absence of environmental variability, and that this tendency to cycle can in turn limit the effectiveness of control in the presence of such variability...

How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection [Trends in Parasitology, 10.1016/j.pt.2013.03.002] — (English)
We propose a model of how the parasite may mediate these effects by direct interaction with B cells via the cysteine-rich interdomain region 1 α (CIDRα) of the erythrocyte membrane protein 1 (PfEMP1) and modulation of the host B cell activating factor (BAFF) immune pathway, and how this may compromise protective immune memory by interfering with B cell differentiation...

The impact of placental malaria on neurodevelopment of exposed infants: a role for the complement system? [Trends in Parasitology, 10.1016/j.pt.2013.03.005] — (English)
Based on recent evidence supporting a role for the complement system in regulating neurodevelopment, and mediating neuroinflammation and neurodegenerative diseases, we hypothesize that excessive complement activation induced by placental malaria may disrupt normal neurodevelopment resulting in neurocognitive impairment of infants exposed to malaria in utero...