22.04.2018

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Announcements / Press Releases

Roll Back Malaria Partnership (RBM) Urges Increased Asian Investment in Fight Against Malaria [RBM] — (English)
HRH Princess Astrid of Belgium, Special Representative of the RBM, Visits Japan & Cambodia in lead-up to World Malaria Day...

Leaders Gather at United Nations in New York for Malaria Lunch & Panel Discussion in Commemoration of World Malaria Day [РБМ] — (English)
In the lead-up to World Malaria Day, commemorated annually around the world on 25 April, the Roll Back Malaria Partnership (RBM) and the United Nations Secretary-General's Special Envoy for Financing Health MDGs and for Malaria, Mr Ray Chambers, co-hosted a malaria lunch and panel discussion at the United Nations Headquarters in New York...

RBM applauds the release of updated guidance on managing severe malaria [WHO] — (English)
The World Health Organisation has released its revised guidance on diagnosing and treating severe forms of malaria and managing complications. The new publication, Management of severe malaria: A practical handbook, addresses clinical professionals in malaria-endemic countries, physicians in non-endemic countries, as well as health personnel in hospitals and health centres with inpatient facilities...

RBM partners and the diplomatic community in Geneva commemorate World Malaria Day [RBM] — (English)
On the occasion of World Malaria Day (25 April), leaders in the global malaria fight addressed ambassadors, diplomats and international civil servants at a working lunch, organised by the Roll Back Malaria Partnership (RBM)...

Mary and Martha: A Mother Tells Her Malaria Tale [Ray Chambers via Huffington post] — (English)
As Special Envoy, I have interacted with people touched by every facet of malaria, but nothing is as sorrowful as meeting a parent who has lost a child from malaria. At the same time, it is their stories that remind us that this is not acceptable and we cannot rest until no child dies from malaria. I recently sat down with Mrs. Jo Yirrell of the United Kingdom to hear her story...

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Articles requiring subscription or registration

The changing epidemiology of malaria elimination: new strategies for new challenges [The Lancet, Early Online Publication, 15 April 2013 doi:10.1016/S0140-6736(13)60310-4] — (English)
Malaria-eliminating countries achieved remarkable success in reducing their malaria burdens between 2000 and 2010. As a result, the epidemiology of malaria in these settings has become more complex. Malaria is increasingly imported, caused by Plasmodium vivax in settings outside sub-Saharan Africa, and clustered in small geographical areas or clustered demographically into subpopulations, which are often predominantly adult men, with shared social, behavioural, and geographical risk characteristics. The shift in the populations most at risk of malaria raises important questions for malaria-eliminating countries, since traditional control interventions are likely to be less effective. Approaches to elimination need to be aligned with these changes through the development and adoption of novel strategies and methods. Knowledge of the changing epidemiological trends of malaria in the eliminating countries will ensure improved targeting of interventions to continue to shrink the malaria map...

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity [PNAS April 18, 2013 doi: 10.1073/pnas.1220360110] — (English)
We explored the life cycle stage specificity of CPS-induced protection...

Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites [pnas.1301251110 PNAS April 15, 2013] — (English)
Here, we report an efficient method for preparing highly purified apicoplasts from red blood cell parasite stages and the comprehensive lipidomic analysis of this organelle. Apicoplasts were prepared from transgenic parasites expressing an epitope-tagged triosephosphate transporter and immunopurified on magnetic beads...

Exogenous gypsy insulator sequences modulate transgene expression in the malaria vector mosquito, Anopheles stephensi [Proc Natl Acad Sci U S A.] — (English)
We applied quantitative approaches that show that exogenous insulator-like DNA derived from the Drosophila melanogaster gypsy retrotransposon can increase and stabilize transgene expression in transposon-mediated random insertions and recombinase-catalyzed, site-specific integrations in the malaria vector mosquito, Anopheles stephensi...

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites [Genes and Immunity, (18 April 2013) doi:10.1038/gene.2013.20] — (English)
We characterized and compared the transcriptional profile of parasite-specific memory CD8+ T cells residing in the liver and spleen after immunization of mice with irradiated sporozoites...

Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice [Genes and Immunity , (18 April 2013) | doi:10.1038/gene.2013.16] — (English)
We used a mouse model of experimental cerebral malaria (ECM) with Plasmodium berghei ANKA to study genetic factors regulating appearance of neurological symptoms and associated lethality...

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites [Nature Communications 4, Article number: 1736 doi:10.1038/ncomms2725] — (English)
Here we demonstrate that calcium-dependent permeabilization of host red blood cells is critical for egress of Plasmodium falciparum merozoites...

Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal [Am J Trop Med Hyg 2013 12-0739] — (English)
Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c...

Asymptomatic Plasmodium Infection and Cognition among Primary Schoolchildren in a High Malaria Transmission Setting in Uganda [Am J Trop Med Hyg 2013 12-0633] — (English)
No associations were observed between anemia and either test of cognition. Schoolchildren in high transmission settings may experience cognitive benefits, from interventions aimed at reducing the prevalence of asymptomatic parasitemia...

A Second Chance to Tackle African Malaria Vector Mosquitoes that Avoid Houses and Don’t Take Drugs [Am J Trop Med Hyg 2013 13-0065] — (English)
The anti-malarial drugs we use in 2013 are relatively new to the front lines but they are still overwhelmingly used in the same way for reactive clinical management of symptomatic cases...

Mathematical Models of Within-Host and Transmission Dynamics to Determine Effects of Malaria Interventions in a Variety of Transmission Settings [Am J Trop Med Hyg 2013 12-0007] — (English)
A model for Anopheles population dynamics and malaria transmission is combined with a within-host dynamics microsolver to study baseline transmission, the effects of seasonality, and the impact of interventions...

Malaria burden in irregular migrants returning to Sri Lanka from human smuggling operations in West Africa and implications for a country reaching malaria elimination [Transactions RSTMH Volume 107, Issue 5Pp. 337-340] — (English)
Facilitating a safe return with selective screening for at-risk inbound migrants flows is desirable as Sri Lanka advances towards its goal of malaria elimination...

Plasmodium vivax malaria in Duffy-negative individuals from Ethiopia [Transactions RSTMH Volume 107, Issue 5Pp. 328-331] — (English)
This study documents the emergence of P. vivax malaria in Duffy-negative individuals in Ethiopia. The Duffy-negative blood group does not appear to provide absolute protection against P. vivax infection in this region...

Genetic evaluation of the performance of malaria parasite clearance rate metrics [J Infect Dis. (2013) doi: 10.1093/infdis/jit165] — (English)
We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which six-hourly parasite counts and 93-SNP parasite genotypes were available...

AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae [jbc.M112.443267, doi: 10.1074] — (English)
Here, using genome-wide transcriptional profiling, bioinformatics and functional gene analysis we identify a new axis of mosquito resistance to monoclonal P. falciparum infections that includes the AP-1 transcription factor Fos and the transglutaminase 2 (TGase2), a cross-linking enzyme with known roles in wound responses...

Safety of Artemisinin-Based Combination Therapies in Nigeria: A Cohort Event Monitoring Study [Drug Safety] — (English)
The main objectives of the CEM programme were to proactively determine the adverse event (AE) profile of artesunate/amodiaquine (AA) and artemether/lumefantrine (AL) in real-life settings and to find out the factors predisposing to AEs...

The Survival of Memory CD8 T Cells That Is Mediated by IL-15 Correlates with Sustained Protection Against Malaria [The Journal of Immunology, 1203396] — (English)
We present a hypothesis consistent with a model whereby intrahepatic CD8 TCM cells, being maintained by IL-15–mediated survival and basal proliferation, are conscripted into the CD8 effector/effector memory T cell pool during subsequent infections...