10.06.2013

Read this issue and previous issues online.

Follow us on:
Follow us on Twitter  Follow us on Facebook  Follow us on Flickr Follow us on YouTube   Follow us on LinkedIn

Announcements / Press Releases

RBM partners to forge a way forward on malaria advocacy post 2015 [RBM] — (English)
A two-day high-level consultation, organised by the Roll Back Malaria Partnership, aims to generate consensus about a common strategy to position the malaria fight in the global development agenda post 2015...

New report analyses progress in rolling back malaria in Madagascar [RBM] — (English)
he national Madagascan Roll Back Malaria Partnership has launched a new report that highlights the efforts made in the fight against malaria on this island state. The deployment of anti-malaria interventions in recent years has led to a significant increase in coverage of malaria prevention and treatment tools. At the national level 80% of households now own at least one mosquito net, which is an increase of 43% in three years. In the 91 districts covered by mass distribution campaigns (of the 111 in total), this percentage rises to 94%. Today, malaria is no longer the first cause of morbidity and mortality in Madagascar which is reflected in the improvement of national health indicators...
Download the report [in English] [in French]
Read the report online [in English] [in French]

RBM Independent External Evaluation (2009-2013) [RBM] — (English)
Download Request for Proposals...

Declaration of Nouakchott on the Initiative of Accelerating the Fight against Malaria in six Neighbouring Countries [Gambia, Mali, Mauritania, Niger, Senegal and Chad] — (English + French)
Six Ministers of Health have signed the Declaration of Noakchott, agreed at a high-level meeting held in May in the presence of Dr. Nafo-Traoré, Executive Director of the Roll Back Malaria Partnership and Dr Matshidiso Moeti, Director Deputy of the WHO African Region. The Ministers of Health of the Gambia, Mali, Mauritania, Niger, Senegal and Chad commited to accelerating efforts to combat malaria. The declaration calls on RBM to provide advocacy and strategic support to this initiative, urges WHO to provide strategic and technical guidance, and asks sub-regional organisations and Regional Economic Communities to help increase funding for health, as well as further explore opportunities for South-South cooperation...
Read Declaration [in English], [in French]


Call for Nominations and Expression of interest in the RBM Southern NGO constituency [RBM] — (English)
The nominations and selection process is being launched on 24th May 2013 with the objective of identifying and mobilizing new representatives and bringing them on board immediately after the May 2013 RBM board meeting. All complete applications should be sent by email to taina@friends-africa.org by 17th June 2013, 18:00 GMT. On the email subject line, please ensure you write “Nomination for RBM Southern NGO constituency Seat”. Download the Call for Nominations and Expression of interest in the RBM Southern NGO constituency...

Mapping of Procurement and Supply Management (PSM) Bottlenecks in Global Fund Grant Implementation Related to Delays in Grant Disbursement: DRC and Tanzania [PSMWG] — (English + French)
[in English], [in French], DRC and Tanzania...

10.06.2013

{title} [{articlesource}] — ({language})
{description}...

09.06.2013

{title} [{articlesource}] — ({language})
{description}...

08.06.2013

{title} [{articlesource}] — ({language})
{description}...

07.06.2013

{title} [{articlesource}] — ({language})
{description}...

06.06.2013

{title} [{articlesource}] — ({language})
{description}...

05.06.2013

{title} [{articlesource}] — ({language})
{description}...

04.06.2013

{title} [{articlesource}] — ({language})
{description}...

Articles requiring subscription or registration

Malaria network using vesicles [Nature Medicine 19, 683 (2013) doi:10.1038/nm.3239] — (English)
Plasmodium, the parasite responsible for malaria, must differentiate once in its life cycle to the sexual stage form, called the gametocyte, to ensure transmission to other hosts. Two new studies show that malaria-infected red blood cells communicate with each other by vesicles, which induces gametocyte production and host immunomodulation...

Mast cells fuel the fire of malaria immunopathology [Nature Medicine 19, 672–674 (2013) doi:10.1038/nm.3227] — (English)
Malaria remains the most deadly human parasitic disease. A new study finds that malaria parasites signal to mast cells to promote disease through the expansion of specialist dendritic cells and the subsequent activation of pathogenic CD8+ T cells...

Severe malaria is associated with parasite binding to endothelial protein C receptor [Nature (2013) doi:10.1038/nature12216] — (English)
Sequestration of Plasmodium falciparum-infected erythrocytes in host blood vessels is a key triggering event in the pathogenesis of severe childhood malaria, which is responsible for about one million deaths every year...

The evolutionary history of Plasmodium vivax as inferred from mitochondrial genomes: parasite genetic diversity in the Americas [Mol Biol Evol (2013) doi: 10.1093/molbev/mst104] — (English)
We show that the diversity of P. vivax in the Americas is comparable to that in Asia and Oceania, and we identify several divergent clades circulating in South America that may have resulted from independent introductions...

Acquired antibodies to merozoite antigens in children from Uganda with uncomplicated or severe Plasmodium falciparum malaria [CVI.00156-13] — (English)
We found higher levels of IgG antibodies towards EBA181, MSP2-3D7/FC27 and AMA1 in patients with uncomplicated malaria by ELISA, but no differences against EBA140, EBA175, MSP1, Rh2 and Rh4 or for IgM against MSP2-3D7/FC27...

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children [Blood June 5, 2013 blood-2013-03-490219] — (English)
We hypothesized that localized cerebral microvascular thrombosis in CM is caused by a decreased expression of the anticoagulant and protective receptors thrombomodulin (TM) and endothelial protein C receptor (EPCR), and that low constitutive expression of these regulatory molecules in the brain make it particularly vulnerable...

Pathogenesis of malaria-associated acute respiratory distress syndrome [Trends in Parasitology, 10.1016/j.pt.2013.04.006] — (English)
We discuss and compare the pathogenesis of MA-ARDS in patients and in different murine models, including recent models without cerebral involvement, and summarize the roles of different leukocyte subclasses, adhesion molecules, cytokines, and chemokines. In patients as well as in mice, severe edema and impaired gas exchange are associated with abundant inflammatory infiltrates consisting of mainly mononuclear cells and parasite sequestration, and the pathogenesis appears different from cerebral malaria (CM). Experimental anti-inflammatory interventions are successful in mice and remain to be validated in patients...