01.07.2013

Read this issue and previous issues online.

Follow us on:
Follow us on Twitter  Follow us on Facebook  Follow us on Flickr Follow us on YouTube   Follow us on LinkedIn

Announcements / Press Releases

Global consultation on developing a multi-sectoral approach to Malaria [RBM] — (English)
Leading international development experts meet in Geneva from 1-3 July to establish new schemes to include malaria control and elimination efforts into broader development activities. Experts from education, housing and urbanization, water management, food security and climate change will review what role their respective field can play in expanding the fight against malaria...

Ten Countries Rally to Eliminate Malaria in Central America and the Caribbean [The Global Fund Press release] — (English)
en countries in Central America and the Caribbean have joined a regional initiative that aims to eliminate malaria by 2020, with support of the Global Fund to Fight AIDS, Tuberculosis and Malaria...

Novartis convenes international malaria experts to expand access to quality-assured antimalarial treatment in Africa [Novartis press release] — (English)
Today national and international leaders from more than 25 countries across Africa are meeting, at the 12th annual National Malaria Control Program (NMCP) Best Practice Sharing Workshop, to discuss the problem of sub-standard antimalarials in Africa and address key topics and challenges faced by the malaria community...

EU and India unite to study malaria [EU CORDIS] — (English)
So the MALSIG ('Signalling in Life Cycle Stages of Malaria Parasites') project set out to develop novel strategies for malaria control, and in turn provide better understanding of the biology of malaria parasites. With funding of EUR 3 million, France's Institut national de la santé et de la recherche médicale (INSERM) formed a unique consortium of EU and Indian partners...

In focus: High-risk groups [GMP/WHO] — (English)
Some population groups are at considerably higher risk of contracting malaria and developing severe disease than others. These include infants, children under five years of age, pregnant women, people living with HIV/AIDS, as well as non-immune migrants, mobile populations and travellers. National malaria control programmes need to adopt targeted measures to protect these population groups from malaria infection, while taking into consideration their specific circumstances. A recently updated section on this website provides more information about related WHO recommendations...

UNICEF: Children are both the makers and the markers of healthy, sustainable societies UNICEF Press release[] — (English)
One year after the Rio+20 Sustainable Development Conference building “The future we want” – Rio’s outcome – will be dependent on children being at the heart of the post-2015 agenda, says UNICEF...

Relentless killer captured by art [Wellcome Trust Sanger Institute] — (English)
Artist Deborah Robinson explores how the Sanger Institute research is fighting malaria in a new digital artwork...

La Toile [WHO/AFRO Malaria Newsletter | Vol. 5 No. 2 | June 2013] — (English)
African leaders urged to increase domestic funding to sustain interventions and ‘defeat malaria’, Small Island Developing States move forward on Malaria Elimination...

AIRS e-Newsletter [AIRS, June 2013] — (English)
One woman's inspiring story, new M&E tool, and more...

01.07.2013

{title} [{articlesource}] — ({language})
{description}...

30.06.2013

{title} [{articlesource}] — ({language})
{description}...

29.06.2013

{title} [{articlesource}] — ({language})
{description}...

28.06.2013

{title} [{articlesource}] — ({language})
{description}...

27.06.2013

{title} [{articlesource}] — ({language})
{description}...

26.06.2013

{title} [{articlesource}] — ({language})
{description}...

25.06.2013

{title} [{articlesource}] — ({language})
{description}...

Articles requiring subscription or registration

Chemical and genetic validation of thiamine utilization as an antimalarial drug target [Nature Communications 4, Article number: 2060 doi:10.1038/ncomms3060] — (English)
Here we show that oxythiamine, a thiamine analog, inhibits proliferation of the malaria parasite Plasmodium falciparum in vitro via a thiamine-related pathway and significantly reduces parasite growth in a mouse malaria model...

Epidemiology: Resistance mapping in malaria [Nature 498, 446–447 (27 June 2013) doi:10.1038/498446b] — (English)
Whole-genome sequencing of human malaria parasites has revealed genomic regions that are associated with resistance to artemisinin-based drugs. The findings may help to explain the origin and spread of this worrying trend...

Severe malaria is associated with parasite binding to endothelial protein C receptor [Nature Volume: 498, Pages: 502–505 Date published: (27 June 2013)DOI: doi:10.1038/nature12216] — (English)
We show that EPCR binding is mediated through the amino-terminal cysteine-rich interdomain region (CIDRα1) of DC8 and group A PfEMP1 subfamilies, and that CIDRα1 interferes with protein C binding to EPCR...

The activation of vivax malaria hypnozoites by infectious diseases [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(13)70095-1] — (English)
We review historical records to examine the association between relapses of Plasmodium vivax and febrile infectious diseases...

Malaria prevalence highest among the poorest of the poor [BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f4025] — (English)
Poverty and malaria are closely interlinked, and a meta-analysis has recently confirmed that even within poor communities, those at the very bottom of the socioeconomic scale have a significantly higher prevalence of malaria than those at the top...

Don’t forget children with imported malaria in non-endemic countries [BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f4042 ] — (English)
We were disappointed by the paucity of information about children in Whitty and colleagues’ review of imported malaria1 since 15-20% of imported malaria occurs in children.2 In the only paragraph on severe or complicated malaria in children the authors quote a paper on endemic childhood malaria in Kenya...

Anopheles gambiae Circumsporozoite-Protein Binding-Protein facilitates Plasmodium infection of mosquito salivary glands [J Infect Dis. (2013) doi: 10.1093/infdis/jit284] — (English)
We now identify an Anopheles salivary gland protein, named CSP-Binding Protein (CSPBP) that interacts with CSP...

Effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine in pregnancy on maternal and infant birth outcomes in Machinga District, Malawi [J Infect Dis. (2013) doi: 10.1093/infdis/jit276] — (English)
IPTp-SP did not reduce placental infection, but was associated with improved birth outcomes. Few women received no SP, so the true effect of IPTp-SP may be underestimated. Malawian pregnant women should continue to receive IPTp-SP, but alternative strategies and antimalarials for preventing MIP should be investigated...

Multiplex 5′ Nuclease Quantitative Real-Time PCR for the Clinical Diagnosis, Speciation, and Epidemiologic Evaluation of Malaria, including Plasmodium knowlesi [JCM.00958-13] — (English)
We developed high-throughput multiplex 5′nuclease quantitative PCR (qPCR) assays, with the potential to support large studies, to specifically identify Plasmodium falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi. We compared qPCR to microscopy and confirmed discordant results with alternative-target PCR...

Exchange Transfusion for Severe Malaria: Evidence Base and Literature Review [Clin Infect Dis. (2013) doi: 10.1093/cid/cit429] — (English)
We examined the efficacy of ET as an adjunct treatment for severe malaria using US surveillance data and reviewed the literature to update recommendations...

Gut microbes influence fitness and malaria transmission potential of Asian malaria vector Anopheles stephensi [Acta Tropica] — (English)
To understand the possible interaction of gut microbes and mosquito host, we examined the contribution of the microbe community on the fitness of the adult mosquitoes and their ability to permit development of the malaria parasite...

Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development [Molecular Microbiology DOI: 10.1111/mmi.12303] — (English)
Using a combination of immunoisolation and liquid chromatography coupled to accurate mass spectrometry, we determined the first acetylome of the human malaria parasite Plasmodium falciparum during its active proliferation in erythrocytes with 421 acetylation sites identified in 230 proteins...

Functional genomics of Plasmodium falciparum using metabolic modelling and analysis [Briefings in Functional Genomics (2013) doi: 10.1093/bfgp/elt017] — (English)
Herein we provide an overview on metabolic modelling, which has the capability to integrate information from functional genomics studies in P. falciparum and guide future malaria research efforts towards the identification of novel candidate drug targets...