15.07.2013

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Announcements / Press Releases

New malaria intelligence gathering unit for 10 hardest-hit African countries [RBM Press release] — (English)
The Malaria Situation Room, a joint initiative that will provide critical malaria intelligence in support of ten African countries, was launched today at a special African Union (AU) Summit on HIV/AIDS, Tuberculosis and Malaria in Abuja, Nigeria...

Création d'une nouvelle unité de collecte d'informations sur le paludisme pour les dix pays africains les plus touchés par ce fléau [Communiqué de presse de RBM] — (French)
La Cellule de crise paludisme est une initiative commune qui permettra d’obtenir des informations essentielles sur la maladie en soutien à dix pays africains. Elle a été lancée aujourd'hui lors d'un Sommet spécial de l'Union Africaine (UA) sur le VIH/sida, la tuberculose et le paludisme, à Abuja (Nigéria)...

RBM highlights malaria fight at Abuja+12 Special Summit [RBM] — (English)
In the run-up to the Abuja+12 Special Summit of the African Union, to be held from 12-16 July, Roll Back Malaria (RBM) partners supported civil society’s inputs into a high-level political declaration, which is expected to reaffirm Africa’s commitment to health and the fight against HIV/AIDS, TB and malaria...

The Malaria Situation Room - Briefing Note [RBM /WHO] — (English)
The Malaria Situation Room: a new malaria initiative to help 10 hardest hit African countries meet global targets...

The Malaria Situation Room - Briefing Note [RBM /WHO] — (French)
Cellule de crise paludisme : une nouvelle initiative antipaludique visant à aider les 10 pays africains les plus touchés par cette maladie à atteindre les objectifs mondiaux...

African Union health leadership commitments since 2000 (Roll Back Malaria) and 2001 Abuja summits [RBM Infographic] — (English)
Infographic showing timeline of the timeline of key African Union health leadership commitments since 2000 (Roll Back Malaria) and 2001 Abuja summits...

Of the 53 African Union Member States, only six have met Abuja 2001 pledge to commit 15% of national budgets to health [RBM] — (English)
RBM photo story...

Since Abuja 2001, 44 African nations have seen >50% reductions in malaria cases [RBM] — (English)
RBM photo story...

Well targeted malaria financing is an investment in healthier and more equitable societies, and an investment in the future [RBM] — (English)
RBM photo story...

Malaria in the Americas presents a complex picture [ASU] — (English)
Human migrations – from the prehistoric epoch to the present day – have extended cultures across the globe. With these travelers have come unwanted stowaways: mosquito-borne parasites belonging to the Plasmodium species – a group responsible for malaria, worldwide....

Technical Officer (Entomologist) [Swiss TPH] — (English)
Application deadline: 16 August 2013...

Technical Officer (Economist) [Swiss TPH] — (English)
Application deadline: 16 August 2013...

15.07.2013

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Articles requiring subscription or registration

Artemisinin therapy and severe delayed haemolysis [The Lancet, Volume 382, Issue 9887, Page 180, 13 July 2013] — (English)
In April, 2012, a 32-year-old white man came to our hospital with fever, lethargy, dyspnoea, and bilateral ankle oedema. He had spent the last 4 months in Togo and had not taken malaria prophylaxis. 15 days previously, he had developed fever and lethargy, and had attended a clinic at which Plasmodium falciparum malaria was diagnosed, with an initial parasitaemia of 1650 parasites per μL. His haemoglobin (Hb) was 128 g/L. He was given 160 mg intramuscular artemether daily for 3 days...

Use of qPCR and Genomic Sequencing to Diagnose Plasmodium ovale wallikeri Malaria in a Returned Soldier in the Setting of a Negative Rapid Diagnostic Assay [Am J Trop Med Hyg 2013 12-0724] — (English)
To our knowledge, this is the first case report in which quantitative real-time polymerase chain reaction amplification using the Cytochrome B gene, coupled with genomic sequencing of the potra locus, was used for definitive diagnosis of P. ovale wallikeri malaria...

Microgeographical Differences of Plasmodium vivax Relapse and Re-Infection in the Peruvian Amazon [Am J Trop Med Hyg 2013 13-0060] — (English)
To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru...

IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages [European Journal of Immunology DOI: 10.1002/eji.201343493] — (English)
We observed a striking reduction in splenic macrophages in the p19KO and 17KO mice, both of which became highly susceptible to infection...

Abundance and diversity of Anopheles species (Diptera: Culicidae) associated with malaria transmission in human dwellings in rural and urban communities in Oyo State, Southwestern Nigeria [Parasitology Research July 2013] — (English)
Mosquito samples were collected from rural and urban communities in three selected major towns in Southwestern Nigeria to determine the impact of urbanization on the diversity and abundance of Anopheles species associated with malaria transmission in human habitations...

ESTABLISHMENT EFFICIENCY AMONG CLONES OF THE MALARIA PARASITE, PLASMODIUM MEXICANUM, FOR MIXED-CLONE INFECTIONS IN ITS NATURAL LIZARD HOST [J Parasitol. 2013 Jul 10] — (English)
Within genetically-diverse infections of malaria parasites (Plasmodium spp.), the relative proportions of genetic clones in the vertebrate host's blood can influence clonal competition, transmission success, gametocyte sex ratio, and virulence...

Current Challenges in Travelers’ Malaria [Current Infectious Disease Reports July 2013] — (English)
Complicated malaria is treated preferably with intravenous artesunate, and the supply and quality of this life-saving antimalarial in some settings can pose one of the most urgent challenges in travelers’ malaria...

Melatonin Signaling and Its Modulation of PfNF-YB Transcription Factor Expression in Plasmodium falciparum [Int. J. Mol. Sci. 2013, 14(7), 13704-13718; doi:10.3390/ijms140713704] — (English)
For many years we have studied how the Plasmodium parasite is able to sense melatonin. In this review we discuss the melatonin signaling pathway and its role in the control of Plasmodium replication and development...

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity [J. Med. Chem., DOI: 10.1021/jm400656s] — (English)
We observed a structural relationship between our compounds and the anti-cancer and anthelmintic compound, pyrvinium pamoate, which has also been proposed to exert its action via compromising mitochondrial function...

Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds [Amino Acids. 2013 Jul 9] — (English)
The aim of obtaining novel vaccine candidates against malaria and other transmissible diseases can be partly based on selecting non-polymorphic peptides from relevant antigens of pathogens, which have to be then precisely modified for inducing a protective immunity against the disease...

lasmodium dipeptidyl aminopeptidases as malaria transmission blocking drug targets [AAC.02495-12] — (English)
Both wild type and Pfdpap2 minus parasites were sensitive to ML4118S indicating that, unlike many anti-malarials, ML4118S has activity against both asexual and sexual stage parasites and that DPAP1 and 3 may be targets for a dual stage drug that can treat patients and block malaria transmission...

Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria [JEM doi: 10.1084/jem.20121972] — (English)
Our data provide key information on the mechanisms behind DC suppression during malaria and will assist in developing strategies to better harness DC’s immunotherapeutic potential...

UNIT 11.20 Cytometry in Malaria—A Practical Replacement for Microscopy? [Current Protocols in Cytometry, DOI: 10.1002/0471142956.cy1120s65] — (English)
Quantitative and objective flow cytometric measurements of cellular constituents such as DNA, RNA, and the malaria pigment hemozoin are now useful in research in malaria biology and pharmacology, and can provide more reliable identification of parasite species and developmental stages and better detection of low-density parasitemia than could microscopy. The same measurements can now be implemented in much smaller, simpler, cheaper imaging cytometers, potentially providing a more accurate and precise diagnostic modality...