22.07.2013

Read this issue and previous issues online.

Follow us on:
Follow us on Twitter  Follow us on Facebook  Follow us on Flickr Follow us on YouTube   Follow us on LinkedIn

Announcements / Press Releases

Status of implementation of 2013 planned Malaria Interventions in 47 African endemic countries and Yemen as of July 2013 [RBM] — (English)
At the close of June 2013, 36 (75%) countries developed and submitted Roadmaps of which 33 (92%) were readable, using the new version...

Réunion annuelle de revue et planification des activités de lutte contre le paludisme en Afrique centrale [RBM CARN] — (English)
29, 30, 31 juillet et 1 août 2013 à Douala, CAMEROUN...

Les échos [RBM CARN] — (English)
July issue. Also available in French...

New way to target an old foe: malaria [MIT News] — (English)
Engineered liver tissue developed at MIT could help scientists test new drugs and vaccines...

Italian Parliamentary Head Urges Support for Global Fund [Global Fund] — (English)
The President of Italy's Chamber of Deputies, Laura Boldrini, said that Italy should resume support for the Global Fund to Fight AIDS, Tuberculosis and Malaria without delay...

Global Fund Welcomes Contribution by France [Global Fund] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria said that it very warmly welcomes the commitment from President François Hollande of France to sustain its role as Europe’s leading contributor...

Workshop: Private Sector Opportunities in IRS and Malaria Control In West Africa [GBC] — (English)
The 2013 West Africa Malaria Workshop will gather key stakeholders from the private sector, national governments, multi-lateral organizations, technical and academic community to connect, share information and exchange best practices...

New publication: Operational manual on larval source management [WHO] — (English)
A new WHO publication entitled Larval source management: a supplementary measure for malaria vector control. An operational manual will provide guidance to national malaria control programmes on the planning, implementation, management and evaluation of larval source management (LSM) programmes...

MMV: Event Coordinator Intern, Access & Product Management [MMV] — (English)
Application deadline: 4 August 2013...

WHO: Technical Officer, P3 [WHO] — (English)
Application deadline: 6 August 2013...

Technical Officer (Entomologist) [Swiss TPH] — (English)
Application deadline: 16 August 2013...

Technical Officer (Economist) [Swiss TPH] — (English)
Application deadline: 16 August 2013...

22.07.2013

{title} [{articlesource}] — ({language})
{description}...

21.07.2013

{title} [{articlesource}] — ({language})
{description}...

20.07.2013

{title} [{articlesource}] — ({language})
{description}...

19.07.2013

{title} [{articlesource}] — ({language})
{description}...

18.07.2013

{title} [{articlesource}] — ({language})
{description}...

17.07.2013

{title} [{articlesource}] — ({language})
{description}...

16.07.2013

{title} [{articlesource}] — ({language})
{description}...

Articles requiring subscription or registration

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax [Cell Host & Microbe, Volume 14, Issue 1, 104-115] — (English)
Here, we establish the liver stages for both Plasmodium falciparum and Plasmodium vivax in a microscale human liver platform composed of cryopreserved, micropatterned human primary hepatocytes surrounded by supportive stromal cells. Using this system, we have successfully recapitulated the full liver stage of P. falciparum, including the release of infected merozoites and infection of overlaid erythrocytes, as well as the establishment of small forms in late liver stages of P. vivax. Finally, we validate the potential of this platform as a tool for medium-throughput antimalarial drug screening and vaccine development...

Two Cases of Plasmodium falciparum Malaria in the Netherlands without Recent Travel to a Malaria-Endemic Country [Am J Trop Med Hyg 2013 13-0213] — (English)
Recently, two patients of African origin were given a diagnosis of Plasmodium falciparum malaria without recent travel to a malaria-endemic country. This observation highlights the importance for clinicians to consider tropical malaria in patients with fever. Possible transmission routes of P. falciparum to these patients will be discussed. From a public health perspective, international collaboration is crucial when potential cases of European autochthonous P. falciparum malaria in Europe re considered...

Irregular Migration as a Potential Source of Malaria Reintroduction in Sri Lanka and Use of Malaria Rapid Diagnostic Tests at Point-of-Entry Screening [Case Reports in Medicine Volume 2013 (2013), Article ID 465906, dx.doi.org/10.1155/2013/465906] — (English)
We describe an irregular migrant who returned to Sri Lanka after a failed people smuggling operation from West Africa. Results...

Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell penetrating peptide octaarginine [AAC.00427-13] — (English)
Here, we investigated whether intracellular delivery of the drug fosmidomycin can be improved by combination with the CPP octaarginine...

Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria [Future Medicinal Chemistry July 2013, Vol. 5, No. 11, Pages 1341-1360 , DOI 10.4155/fmc.13.51 (doi:10.4155/fmc.13.51)] — (English)
The gradual generation of drug resistance imposes an urgent need for the development of new and selective antimalarial agents. Kinetic isotope effects coupled to computational chemistry have provided the relevant details on geometry and charge of enzymatic transition states to facilitate the design of transition-state analogs. These features have been reproduced into chemically stable mimics through synthetic chemistry, generating inhibitors with dissociation constants in the pico- to femto-molar range. Transition-state analogs are expected to contribute to the control of malaria...

Multiple Genotypes of the Commonly Co-Segregating Toll-Like Receptor 4 Asp299Gly and Thr399Ile in Baluchi Malaria Patients from Iran. [Cell J. 2013 Summer;15(2):182-9] — (English)
In the current immunogenetic study, we assessed the TLR4 genotypes formed by the two common single nucleotide polymorphisms (SNPs) (Asp299Gly and Thr399Ile) in the co-segregate state in Baluchi Plasmodium falciparum infected and healthy populations from malaria hypoendemic areas of Iran. The study was performed to evaluate the distribution and correlation of TLR4 co-segregating genotypes in patients with mild malaria...