5.08.2013

Read this issue and previous issues online.

Follow us on:
Follow us on Twitter  Follow us on Facebook  Follow us on Flickr Follow us on YouTube   Follow us on LinkedIn

Announcements / Press Releases

Annual RBM planning meeting in Central Africa [RBM CARN] — (English)
As the 2015 deadline approaches, national malaria control programme managers and partners from malaria-endemic countries in central Africa gather to review progress to date and develop strategies and plan for achieving the ambitious 2015 targets in a situation of reduced access to international donor funding...

Be the Generation to Defeat AIDS, TB and Malaria ft Charlize Theron and Bono [Global Fund] — (English)
As the Global Fund seeks new funding for the fight against AIDS, tuberculosis and malaria, Charlize Theron, Bono, Bill Gates, Ngozi Okonjo-Iweala, and others call on world leaders to be the generation to defeat the three pandemics. “The moment is right now” says Charlize Theron, speaking of the critical turning point of progress through science, dropping infection rates and expanded efforts to prevent and treat the three pandemics...

UNFPA to Increase Access to Reproductive Health Services for Millions of Adolescent Girls in Africa [UNFPA Press release] — (English)
The UN agency will support programmes in eight countries on the African continent over the next three years to give marginalized youth access to family planning...

MMV Junior Financial Controller [MMV] — (English)
Application deadline: 2 September 2013...

RBM French Media Consultancy 2013/2014 [RBM] — (English)
Application deadline: 16 August 2013...

Technical Officer (Economist) + Technical Officer (Entomologist) [Swiss TPH] — (English)
Application deadline: 16 August 2013...

05.08.2013

{title} [{articlesource}] — ({language})
{description}...

04.08.2013

{title} [{articlesource}] — ({language})
{description}...

03.08.2013

{title} [{articlesource}] — ({language})
{description}...

02.08.2013

{title} [{articlesource}] — ({language})
{description}...

01.08.2013

{title} [{articlesource}] — ({language})
{description}...

31.07.2013

{title} [{articlesource}] — ({language})
{description}...

30.07.2013

{title} [{articlesource}] — ({language})
{description}...

Articles requiring subscription or registration

Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion [Nature Communications 4, Article number: 2261 doi:10.1038/ncomms3261] — (English)
Here we identify the first inhibitor of this interaction that also blocks merozoite invasion in genetically distinct parasites by screening a library of over 21,000 compounds. We demonstrate that this inhibition is mediated by the small molecule binding to AMA1 and blocking the formation of AMA1–RON complex...

Lipid bilayer and cytoskeletal interactions in a red blood cell [PNAS] — (English)
We studied the membrane fluctuations of healthy RBCs and RBCs parasitized to different intraerythrocytic stages by the malaria-inducing parasite Plasmodium falciparum...

Maternal Clinical Findings in Malaria in Pregnancy in a Region of Northwestern Colombia [Am J Trop Med Hyg 2013 12-0205] — (English)
The proportion of severe cases was similar for both species (P = 0.41). In malaria-endemic areas of Colombia, malaria in pregnancy has a broad clinical spectrum. In pregnant women, P. vivax infection frequently leads to organ-specific complications...

Pooled deep sequencing of Plasmodium falciparum isolates: an efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes [J Infect Dis. (2013) doi: 10.1093/infdis/jit392] — (English)
We designed and validated a SGS protocol to quantify mutant allele frequencies in the Plasmodium falciparum genes dhfr and dhps in mixed isolates. We applied this new protocol to field isolates from children and compared it to standard genotyping using Sanger sequencing...

Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers [J Infect Dis. (2013) doi: 10.1093/infdis/jit394] — (English)
This experimental system results in in vivo parasite growth, likely infectious to mosquitos. It offers the opportunity to undertake studies previously impossible in P. vivax that will facilitate a better understanding of the pathology of vivax malaria and development of antimalarial drugs and vaccines...

Placental malaria and the risk of malaria in infants in a high malaria transmission area in Ghana: a prospective cohort study [J Infect Dis. (2013) ] — (English)
There was no suggestion that exposure to PM directly increased incidence of malaria among infants of MG. In our study area, absence of placental malaria in PG is a marker of low exposure, and this probably explains the lower incidence of malaria-related outcomes among infants of PM negative PG...

Associations between maternal helminth and malaria infections in pregnancy, and clinical malaria in the offspring: a birth cohort in Entebbe, Uganda [J Infect Dis. (2013) doi: 10.1093/infdis/jit397] — (English)
This is the first report of an association between helminth infections in pregnancy and malaria in the offspring, and indicates that helminth infections in pregnancy may increase the burden of childhood malaria morbidity...

Differential protein expression profiles between Plasmodium falciparum parasites isolated from subjects presenting with pregnancy-associated malaria and uncomplicated malaria in Benin [J Infect Dis. (2013) doi: 10.1093/infdis/jit377] — (English)
These proteomics data demonstrate the involvement of selected proteins in the pathophysiology of PAM, providing new insights for the definition of potential new targets for a vaccine against PAM...

Seroreactivity to the PfEMP1 intracellular domain in malaria-exposed children and adults [J Infect Dis. (2013) doi: 10.1093/infdis/jit339] — (English)
Over a malaria season, children maintained this differential seroreactivity and recognized additional intracellular PfEMP1 fragments. This approach has the potential to identify conserved, seroreactive extracellular PfEMP1 domains critical for protective immunity to malaria...

The endothelial protein C receptor and malaria [blood-2013-06-508531 Blood August 1, 2013 vol. 122 no. 5 624-625] — (English)
In this issue of Blood, Moxon et al provide novel insight into the pathogenesis of cerebral malaria, linking loss of the endothelial protein C receptor (EPCR) on brain vessels, caused by cytoadherent infected erythrocytes, with localized coagulation, inflammation, and disruption of endothelial barrier function...

Mutant Plasmodium falciparum chloroquine resistance transporter in Hodeidah, Yemen: Association with parasitologic indices and treatment-seeking behaviors [Acta Tropica] — (English)
High pfcrt T76 frequency still prevails among P. falciparum populations in Hodeidah. Pfcrt T76 was associated with young age, low parasite density and gametocytemia. Delayed treatment and frequent use of antimalarials were associated with pfcrt T76...

Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon [Acta Tropica] — (English)
Patients with previous chloroquine-induced pruritus had a high risk for developing pruritus. Due to its high frequency, this side effect cannot be neglected as it can have major implications on patients’ compliance to treatment hampering elimination efforts in the region...

A novel long non-coding RNA T-ALL-R-LncR1 and Par-4 cooperated to induce cellular apoptosis in T cell acute lymphoblastic leukemia cells [Leuk Lymphoma. 2013 Aug 2] — (English)
Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells. Our studies indicated a potential role of suppressing the novel long non-coding RNA T-ALL-R-LncR1 in the therapy of human T-ALL...

The interplay between drug resistance and fitness in malaria parasites [Molecular Microbiology, DOI: 10.1111/mmi.12349] — (English)
Available data indicate that, as with other microorganisms, the spread of drug-resistant malaria parasites is limited by fitness costs that frequently accompany resistance. Resistance-mediating polymorphisms in malaria parasites have been identified in putative drug transporters and in target enzymes. The impacts of these polymorphisms on parasite fitness have been characterized in vitro and in animal models...

Development of Severe Pathology in Immunized Pregnant Mice Challenged with Lethal Malaria Parasites [IAI.00749-13] — (English)
These findings suggest that development of liver injury and placental pathology in pregnant immune mice challenged/infected with P. berghei NK65 is accompanied by enhanced production of proinflammatory cytokines...

Inducing humoral and cellular responses to multiple sporozoite and liver stage malaria antigens using pDNA [IAI.00180-13] — (English)
Here, we report the preclinical assessment of an optimized DNA vaccine approach that targets four Pf antigens: circumsporozoite protein (CSP), liver stage antigen 1 (LSA1), thrombospondin-related-anonymous-protein (TRAP), and cell-traversal protein for ookinetes and sporozoites (CelTOS)...