12.08.2013

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Announcements / Press Releases

Malaria — Multisectoral Approach [RBM] — (English)
New section on the RBM web which includes overview of multisectoral approach to malaria, documents library, news section and material of Consultation on Developing a Multisectoral Approach to Malaria,that took place on 1-3 July 2013 ...

RBM contributes to multisectoral ministerial consultations on maternal, newborn and child health [CARMMA] — (English)
The RBM Executive Director, Dr Fatoumata Nafo-Traoré, and the Nigerian Minister of Health, Professor Onyebuchi Chukwu, chaired a session on the role of international organizations in multisectoral action in the context of the African Union’s International Conference on Maternal, Newborn and Child Health, held on 1 to 3 August in Johannesburg...

Investigational Malaria Vaccine Found Safe and Protective NIH Vaccine Researchers Publish Results of Early-Stage Clinical Trial [NIAID press release] — (English)
An investigational malaria vaccine has been found to be safe, to generate an immune system response, and to offer protection against malaria infection in healthy adults, according to the results of an early-stage clinical trial published Aug. 8 in the journal Science...

MSU-developed software to help in war on cerebral malaria [Michigan State University news release] — (English)
Michigan State University researchers and programmers have developed new software that helps doctors understand how cerebral malaria damages the brain and will ultimately save more of the 3 million children affected by the disease each year. The team introduces the tool, called NeuroInterp, in the Aug. 5 issue of Neurology, the medical journal of the American Academy of Neurology...

DNDi Annual Report 2012 [DNDi] — (English)
Through its annual reports, DNDi publishes the main achievements of its R&D projects and activities, and provides comprehensive information about the organization’s performance and latest accomplishments in the field of neglected diseases...

New publication: Field guide on seasonal malaria chemoprevention [WHO] — (English)
The WHO Global Malaria Programme has released a new publication to support and facilitate the implementation of seasonal malaria chemoprevention (SMC). SMC is recommended in areas of highly seasonal malaria transmission throughout the Sahel sub-region of Africa. The publication, entitled Seasonal malaria chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine in children: A field guide, provides the necessary technical and operational information and tools for country-level policy-makers and programme managers to decide on the adoption and implementation of SMC...

New publication: Operational manual on larval source management [WHO] — (English)
A new WHO publication entitled Larval source management: a supplementary measure for malaria vector control. An operational manual will provide guidance to national malaria control programmes on the planning, implementation, management and evaluation of larval source management (LSM) programmes. LSM refers to the targeted management of mosquito breeding sites, with the objective to reduce the number of mosquito larvae and pupae. LSM is only recommended as a supplementary malaria vector control measure; it should not be used to replace core vector control interventions, such as long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS)...

French Media Consultancy 2013/2014 [RBM] — (English)
Application deadline: 16 August 2013...

Junior Financial Controller [MMV] — (English)
Application deadline: 2 September 2013...

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Articles requiring subscription or registration

Unconventional Vaccine Shows Promise Against Malaria [Science 9 August 2013: Vol. 341 no. 6146 p. 605 DOI: 10.1126/science.341.6146.605] — (English)
For the past decade, tropical disease researcher Stephen Hoffman has been obsessed with a quixotic scheme for making a malaria vaccine: by bottling weakened malaria parasites...

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine [cience DOI: 10.1126/science.1241800] — (English)
These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved by IV administration of a vaccine that is safe and meets regulatory standards...

Getting antimalarials on target: impact of national roll-out of malaria rapid diagnostic tests on health facility treatment in three regions of Tanzania [Tropical Medicine & International Health, DOI: 10.1111/tmi.12168] — (English)
Roll-out of mRDTs in Tanzania dramatically improved diagnostic testing for malaria and reduced overuse of ACTs for patients without parasitemia. However, post–roll-out almost 50% of febrile patients did not receive a diagnostic test, and almost 50% of patients testing positive did not receive ACTs. Stock-outs of ACTs and mRDTs were important problems. Further investigation is needed to determine reasons for not providing ACTs to patients with malaria and potential for inappropriate antibiotic use...

The causal effect of malaria on stunting: a Mendelian randomization and matching approach [Int. J. Epidemiol. (2013) doi: 10.1093/ije/dyt116] — (English)
The method applied in this study indicates a causal relationship between malaria and stunting in young children in an area of high endemicity and demonstrates the usefulness of the sickle cell trait as an instrument for the analysis of conditions that might be causally related to malaria...

A Randomized Comparison of Dihydroartemisinin-Piperaquine and Artesunate-Amodiaquine Combined with Primaquine for Radical Treatment of Vivax Malaria in Sumatera, Indonesia [J Infect Dis. (2013) doi: 10.1093/infdis/jit407] — (English)
n North Sumatera, Indonesia, AAQ and DHP, both combined with primaquine, were effective for blood stage parasite clearance of uncomplicated P.vivax malaria. Both treatments were safe, but DHP+PQ was better tolerated...

Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis [Cell Death and Disease (2013) 4, e762; doi:10.1038/cddis.2013.286] — (English)
Targeting critical points of susceptibility in the LS-infected host cell might provide new avenues for malaria prophylaxis...

Cell-based Medicinal Chemistry Optimization of High Throughput Screening (HTS) Hits for Orally Active Antimalarials-Part 2: Hits from SoftFocus Kinase and other Libraries [J. Med. Chem., Just Accepted Manuscript DOI: 10.1021/jm400279y] — (English)
In the second part of this Mini-Perspective series, we highlight our medicinal chemistry efforts involving progression of hits from whole cell high-throughput screening (HTS) of a SoftFocus kinase library against the malaria parasite Plasmodium falciparum . Successful SAR exploration in Hit-to-Lead and Lead Optimization efforts leading to the selection of a preclinical development candidate are demonstrated. Related efforts by researchers from Broad/Genzyme, Anacor and GSK are briefly covered...

Contrasting pediatric and adult cerebral malaria: The role of the endothelial barrier [Virulence. 2013 Aug 2;4(6)] — (English)
We hypothesize that post-natal developmental changes, occurring in both endothelial response and the neurovascular unit, account for the differences observed in the clinical presentations of cerebral malaria in children compared with adults...