19.08.2013

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Announcements / Press Releases

RBM contributes to multisectoral ministerial consultations on maternal, newborn and child health [RBM] — (English)
The RBM Executive Director, Dr Fatoumata Nafo-Traoré, and the Nigerian Minister of Health, Professor Onyebuchi Chukwu, chaired a session on the role of international organizations in multisectoral action in the context of the African Union's International Conference on Maternal, Newborn and Child Health, held on 1 to 3 August in Johannesburg...

Recommendations of 2013 CARN NMCPs annual review and planning meeting [CARN] — (English)
View Recommendations of 2013 CARN NMCPs annual review and planning meeting [in English], [in French], [in Spanish], [in Portuguese]...

Detecting early-stage malarial infection [MIT News] — (English)
New prototype device recognizes electrical properties of infected cells as signatures of disease...

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Articles requiring subscription or registration

Long-lasting transition toward sustainable elimination of desert malaria under irrigation development [PNAS 10.1073/pnas.1305728110 ] — (English)
Our results should help to define and track these transitions in other arid parts of the world subjected to similar tradeoffs...

Intravenous vaccine shows promise against malaria [BMJ 2013;347:f5058] — (English)
A vaccine consisting of a live but attenuated form of the most deadly malaria parasite has shown promising protective effects against malaria when given to people intravenously in early trials...

Getting antimalarials on target: impact of national roll-out of malaria rapid diagnostic tests on health facility treatment in three regions of Tanzania [Tropical Medicine & International Health] — (English)
To evaluate the impact on case management practices of routine government implementation of mRDTs, we conducted large-scale health facility surveys in three regions of Tanzania before and after mRDT roll-out...

Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence [J Infect Dis. (2013) doi: 10.1093/infdis/jit431] — (English)
We determined parasite clearance dynamics by duplex quantitative PCR (qPCR) in samples collected in the first three days after treatment of uncomplicated malaria with ACT...

Randomised controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitaemia [J Infect Dis. (2013) doi: 10.1093/infdis/jit410] — (English)
There was no benefit of a single dose levamisole hydrochloride as adjuvant to intravenous artesunate in the treatment of adults with severe falciparum malaria. Rapid parasite killing by intravenous artesunate might obscure the effects of levamisole...

Identification of biochemically distinct properties of the SUMO conjugation pathway in Plasmodium falciparum [jbc.M113.498410] — (English)
Here, we demonstrate that sumoylation levels peak during mid stages of the intra-erythrocyte developmental cycle (IDC), concomitant with hemoglobin consumption and elevated oxidative stress. In vitro studies revealed that P. falciparum E1 and E2 conjugating enzymes interact effectively to recognize and modify RanGAP1, a model mammalian SUMO substrate...

Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy [Amino Acids] — (English)
A first approach to discover new antimalarials has been recently performed in a combined approach with data from GlaxoSmithKline Tres Cantos Antimalarial Set, Novartis-GNF Malaria Box Data set and St. Jude Children’s Research Hospital. These data are assembled in the Malaria Box. In a first phenotypic forward chemical genetic approach, 400 chemicals were employed to eradicate the parasite in the erythrocytic stages...

Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro [IAI.00428-13] — (English)