16.09.2013

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Announcements / Press Releases

Malaria and Poverty [RBM] — (English)
New RBM Video...

Focus on South Africa: A new RBM & Impact Series repoprt coming soon [RBM] — (English)
The report will be launched during the 6th MIM Pan-African Malaria Conference organized from October 6-11, 2013 in Durban, South Africa...

UN: Global child deaths down by almost half since 1990 [WHO, UNICEF, World Bank Group, UN-DESA Population Division joint news release] — (English)
In 2012, approximately 6.6 million children worldwide – 18 000 children per day – died before reaching their fifth birthday, according to a new report released today by UNICEF, WHO, the World Bank Group and the United Nations Department of Economic and Social Affairs/Population Division. This is roughly half the number of under-fives who died in 1990, when more than 12 million children died...

At ‘tipping point’ in fight against AIDS, TB and malaria, UN-backed fund seeks 15B to defeat pandemics [UN News Centre] — (English)
With a $15 billion investment over the next three years, the global community can make huge strides towards defeating HIV/AIDS, tuberculosis and malaria – saving both missions of dollars and millions of lives, according to a new report by the United Nations-backed fund to fight the pandemics...

DFID invests to save millions from deadly diseases [DFID] — (English)
Millions of lives could be saved by new health treatments to combat some of the world’s most debilitating and deadly diseases, following support from the UK government...

Getting to universal diagnosis and treatment of malaria [MalariaCare bulletin] — (English)
A MalariaCare webinar: Wednesday, September 25, 2013, 9:00 to 10:30 AM EST/ 13:00 to 14:30 GMT ...

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Articles requiring subscription or registration

Total protection from malaria [Nature Medicine 19, 1102 (2013) doi:10.1038/nm.3349] — (English)
Finding a malaria vaccine that can confer full protection has been elusive until now. Intravenous injection of irradiated Plasmodium falciparum sporozoites, the infective stage of the malaria parasite, protected adults from malaria infection in a phase 1 trial...

Malaria prevention: civilisation versus disease [The Lancet, Volume 382, Issue 9895, Page 834] — (English)
Malaria, which draws its name from the “bad air” of wetlands, has beset humankind for thousands of years and still imposes a regrettable burden of morbidity and mortality today...

Global Fund needs $15bn to fight HIV, tuberculosis, and malaria [BMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f5601] — (English)
The Global Fund to Fight Aids, Tuberculosis, and Malaria is asking international donors for $15bn (£9.5bn; €11.3bn) as an “absolute minimum” to fight the diseases over the next three years. Mark Dybul, executive director of the Global Fund, told a telephone press conference that the scientific advances and increased investment of the past 10 years presented the world with a unique window of opportunity...

Density-Dependent Blood Stage Plasmodium falciparum Suppresses Malaria Super-Infection in a Malaria Holoendemic Population [Am J Trop Med Hyg 2013 13-0049] — (English)
We have analyzed data from a treatment-time-to-infection cohort of children < 10 years of age residing in a malaria holoendemic area of Kenya where people experience a new blood-stage infection approximately every 2 weeks. We hypothesized that if high parasitemia blocked the liver stage, then high levels of parasitemia should be followed by a “skipped” peak of parasitemia...

Prevalence and Implications of Cerebrospinal Fluid Leukocytosis in Papua New Guinean Children Hospitalized with Severe Malaria [Am J Trop Med Hyg 2013 13-0281] — (English)
Cerebrospinal fluid leukocytosis is infrequent in severe pediatric malaria, especially in children with P. vivax infections, and it is generally mild. Its presence in a blood slide–positive child should prompt consideration of alternative diagnoses and empiric antibiotic therapy...

Factoring Quality Laboratory Diagnosis into the Malaria Control Agenda for Sub-Saharan Africa [Am J Trop Med Hyg 2013 vol. 89 no. 3 403-406] — (English)
A synthesis of the challenges faced in ensuring quality malaria testing and how to include this information in the malaria control and elimination agenda are presented...

Mapping ‘partially resistant’, ‘fully resistant’, and ‘super resistant’ malaria [Trends in Parasitology, 10.1016/j.pt.2013.08.002] — (English)
There are three East African foci where ‘fully resistant’ populations have additionally acquired dhps 581G and/or dhfr 164L to become ‘super resistant’. SP-IPT in infants and pregnant women is reported to have failed in super resistant areas prompting review of SP-IPT use in affected areas...

Plasmodium falciparum Hsp70-x: a heat shock protein at the host–parasite interface [ Journal of Biomolecular Structure and Dynamics] — (English)
This work highlighted the possible dependence of the substrate-binding domain residues on the orientation of the α-helical lid for formation of the substrate-binding pocket...

Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era [Future Medicinal Chemistry September 2013, Vol. 5, No. 13, Pages 1573-1591 , DOI 10.4155/fmc.13.121] — (English)
Medicinal chemistry activity has largely focused on inhibitors of the parasite cytochrome bc1 Complex (Complex III) including acridinediones, pyridones and quinolone aryl esters, as well as inhibitors of dihydroorotate dehydrogenase that includes triazolopyrimidines and benzimidazoles. Common barriers to progress and opportunities for novel chemistry and potential additional electron transport chain targets are discussed in the context of the target candidate profiles for uncomplicated malaria...

Economics of Malaria Prevention in United States Travelers to West Africa [Clin Infect Dis. (2013) doi: 10.1093/cid/cit570] — (English)
Our model suggests that healthcare payers save money for short and longer term trips, and that travelers save money for longer term trips when travelers adhere to malaria recommendations and prophylactic regimens in West Africa...