07.10.2013

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Announcements / Press Releases

6th Multilateral Initiative on Malaria opens in Durban [RBM] — (English)
Leading malaria experts and policy makers have gathered at the sixth Pan-African Conference of the Multilateral Initiative on Malaria (MIM) that opened on Sunday in Durban, South Africa...

Roll Back Malaria Progress & Impact Series: Focus on South Africa [RBM] — (English)
The report will be launched during the 6th MIM Pan-African Malaria Conference organized from October 6-11, 2013 in Durban, South Africa...

UK Government and UNICEF cooperate to increase use of bednets to reduce burden of malaria in Ghana [DFID News release] — (English)
The UK government through the Department for International Development (DFID) will work with UNICEF to increase the use of long lasting insecticide nets (LLINs) in Ghana...

Malaria research receives NIH grant [Saint Louis University News] — (English)
The fight against malaria has taken a new turn with the research of Marvin Meyers, Director of Chemistry at the Center for World Health and Medicine at Saint Louis University. Meyers and his research team recently identified two new classes of compounds that could have the potential to be used in the future in antimalarial drugs. The National Institutes of Health (NIH) granted $566,000 to the Center for World Health and Medicine for further study of these compounds and their effectiveness against the malaria parasite....

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Articles requiring subscription or registration

Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy [Sci. Transl. Med. DOI: 10.1126/scitranslmed.3006684] — (English)
We devised an in vitro system for P. falciparum, capable of mimicking the dynamic fluctuations of a drug in vivo...

Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru [Scientific Reports 3, Article number: 2797 doi:10.1038/srep02797] — (English)
We hypothesized that pfhrp2-deleted parasites in Peru derived from a single genetic event...

Malaria Vaccine, Ebola Therapy Promising in Early Studies [JAMA. 2013;310(13):1327-1328. doi:10.1001/jama.2013.278188] — (English)
One team of researchers demonstrated in a small, preliminary trial that intravenous injections of purified cryopreserved Plasmodium falciparum sporozoites can successfully protect individuals against malaria infection...

Validation of ELISA for Quantitation of Artemisinin-Based Antimalarial Drugs [Am J Trop Med Hyg 2013 12-0592] — (English)
Our results showed that the icELISA has the potential to be improved for quality assurance of ARTs at the point of care in endemic settings...

Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast [Am J Trop Med Hyg 2013 13-0250] — (English)
These results show a profound reduction in malaria transmission in coastal Kenya...

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria. [N Engl J Med 2013; 369:1381-1382] — (English)
Primaquine is the only medication approved by the Food and Drug Administration to eradicate the hypnozoites of Plasmodium vivax, but relapses of P. vivax malaria due to drug failure occur...

Novel approaches in antimalarial drug discovery [Expert Opin Drug Discov.] — (English)
The authors review the classical and new approaches to antimalarial drug discovery, with a special emphasis on the various stages of the parasite's life cycle and the different Plasmodium species. The authors discuss the methodologies and strategies for early efficacy testing that aim to narrow down the portfolio of promising compounds...

ASFA Guidelines support use of red cell exchange transfusion for severe malaria with high parasitemia [Clin Infect Dis. (2013) doi: 10.1093/cid/cit662] — (English)
By Shaz BH, Schwartz J, Winters JL, Padmanabhan A, Balogun RA, Delaney M, Szczepiorkowski ZM, Williams ME, Wu Y, Linenberger ML....

Occurrence of multiple chloroquine-resistant Pfcrt haplotypes and emergence of the S(agt)VMNT type in Cameroonian Plasmodium falciparum [J. Antimicrob. Chemother. (2013) doi: 10.1093/jac/dkt388] — (English)
The main objective of this study was to unravel the distribution of different Pfcrt genotypes in the central, littoral, eastern and southern regions of Cameroon and also in locations bordering Gabon and Equatorial Guinea...

Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity [Nucl. Acids Res. (2013) doi: 10.1093/nar/gkt881] — (English)
To better understand how malaria parasites repair DSBs and maintain genome integrity, we modified the yeast I-SceI endonuclease system to generate inducible, site-specific DSBs within the parasite’s genome...

Acute Plasmodium chabaudi Infection Dampens Humoral Responses to a Secondary T-Dependent Antigen but Enhances Responses to a Secondary T-Independent Antigen [The Journal of Immunology September 30, 2013 1301450] — (English)
These data suggest that during P. chabaudi infection, there is a shift toward an extrafollicular Ab response that could be responsible for decreased Ab responses to secondary T-dependent Ags...