14.10.2013

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Announcements / Press Releases

Roll Back Malaria Progress & Impact Series — Focus on South Africa [RBM] — (English)
The South African Department of Health and the Roll Back Malaria Partnership (RBM) released a new report, the RBM Progress and Impact Series – Focus on South Africa. The report documents South Africa's decades long and successful fight against malaria and highlights SA's leading role in the goal to eradicate this disease which claims over 600,000 lives globally every year. SA's sustained and dedicated action has greatly contributed to the country meeting the sixth Millennium Development Goal (MDG 6), which calls on countries to reverse the incidence of malaria. Over the period 2000-2012, malaria morbidity and mortality declined by a remarkable 89% and 85% respectively from 64,500 cases to 6,847 cases and from 460 deaths to 70 deaths...

GAVI statement on latest trial data on malaria vaccine candidate RTS,S [GAVI Statement] — (English)
Latest data published by Glaxosmithkline and PATH Malaria Vaccine Initiative...

Questions and answers on malaria vaccines [WHO] — (English)
October 2013 Update...

Chad: Malaria peak, a preventable emergency [MSF] — (English)
While Médecins Sans Frontières (MSF) is responding to an acute malaria peak in Chad, the first results from a prevention campaign carried out in the south of the country are spectacular. Seventy per cent less cases have been reported after the distribution of a preventive treatment. This brings real hope for the fight against malaria, the number one killer of children under five in Chad...

Luxembourg’s Commitment is Very Generous, Per Capita [The Global Fund] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria today congratulated Luxembourg for its decision to commit EUR 7.5 million (US$10.1 million) for 2014-2016, making it one of the most generous donors on a per capita basis...

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Articles requiring subscription or registration

Candidate malaria vaccine becomes less effective over time, study shows [BMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f6098] — (English)
A candidate vaccine against malaria has been shown to almost halve the number of malaria cases in young children but only to reduce cases by a quarter in infants. The effectiveness of the vaccine was also found to decline over time, the 18 month results from a large phase III trial show. However, the vaccine’s manufacturer, GlaxoSmithKline, said that it was encouraged by the results and plans to submit a regulatory application to the European Medicines Agency in 2014. If it succeeds this will be the world’s first malaria vaccine...

Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion [Nature Communications 4, Article number: 2552 doi:10.1038/ncomms3552] — (English)
These genetic data have implications on the use of apical membrane antigen 1 or the apical membrane antigen 1–rhoptry neck 2 interaction as targets of intervention strategies against malaria or other diseases caused by apicomplexans...

Comparing actual and perceived causes of fever among community members in a low malaria transmission setting in northern Tanzania [Tropical Medicine & International Health, DOI: 10.1111/tmi.12191] — (English)
Malaria is perceived to be a much more common cause of fever than hospital studies indicate, whereas other important diseases are under-appreciated in northern Tanzania. Belief in non-biomedical explanations of fever is common locally and has important public health consequences...

High diversity of West African bat malaria parasites and a tight link with rodent Plasmodium taxa [10.1073/pnas.1311016110 PNAS] — (English)
o provide a molecular framework for the study of these parasites, we surveyed bats in three remote areas of the Upper Guinean forest ecosystem...

Impact of trehalose transporter knockdown on Anopheles gambiae stress adaptation and susceptibility to Plasmodium falciparum infection [PNAS doi: 10.1073/pnas.1316709110 ] — (English)
These data reveal important roles for AgTreT1 in stress adaptation and malaria pathogen development in a major vector mosquito. Thus, AgTreT1 may be a potential target for malaria vector control...

Plasmodium falciparum polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin [10.1128/AAC.01790-12] — (English)
We assessed the association of Plasmodium falciparum polymorphisms and ex vivo drug susceptibility with clinical effectiveness...