21.10.2013

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Announcements / Press Releases

Public-private partnership success on malaria lauded at GBCHealth Africa Regional Conference [RBM] — (English)
Malaria control investments bring such a high rate of return that they are an easy business choice for Southern African companies, according to business leaders who were sharing their experiences of tackling malaria at the Inaugural GBCHealth Africa Regional Conference...

Francophone Parliamentarians consider integrating malaria into HIV network [RBM] — (English)
Dr Victor Makwenge Kaput, Chair of the Roll Back Malaria Partnership Board, was invited to provide a keynote speech on malaria at an annual meeting of the HIV/AIDS network of the Parliamentary Assembly of La Francophonie...

PSM Working group holds their tenth meeting [RBM PSMWG] — (English)
The RBM procurement and supply management (PSM) working group met to review progress achieved in 2013 and develop an implementation plan for 2014...

Malaria control in humanitarian emergencies – An inter-agency field handbook. Second edition [WHO] — (English)
This second edition represents a thorough updating and revision of the first edition. The structure remains similar, but includes an additional chapter on humanitarian coordination. All chapters have been revised to reflect changes in best practices, improvements in technologies, availability of new tools, and changes in WHO recommendations...

Optimizing the delivery of malaria-in-pregnancy interventions [RBM MIPWG] — (English)
MIP Consensus Statement...

New $25 ASTMH Membership Rate [ASTMH] — (English)
ASTMH Introduces Reduced $25 Membership Rate for Low- and Lower-Middle Income Countries ...

Senior Legal Officer [MIM] — (English)
Application deadline: 31 October 2013...

Senior Program Officer, Vector Control (Malaria) [Bill & Melinda Gates Foundation] — (English)
Requisition Number 4089BR...

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Articles requiring subscription or registration

MIM conference focuses on malaria elimination [The Lancet, Volume 382, Issue 9901, Pages 1319 - 1320, 19 October 2013] — (English)
Researchers gathered for the 6th Multilateral Initiative in Malaria (MIM) Pan-African Conference last week to discuss challenges to malaria elimination. Adele Baleta reports from Durban...

Antimalarial drug resistance in Bangladesh, 1996–2012 [Trans R Soc Trop Med Hyg (2013) doi: 10.1093/trstmh/trt088] — (English)
In this study, we reviewed and summarized antimalarial drug resistance data from Bangladesh published until June 2013. We searched published sources for data referring to any type of P. falciparum drug resistance (in vivo, in vitro, or molecular) and found 169 articles published in peer-reviewed journals. Of these, 143 articles were excluded because they did not meet our inclusion criteria...

Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis [rans R Soc Trop Med Hyg (2013) 107 (11): 672-683. doi: 10.1093/trstmh/trt086] — (English)
This study aimed to synthesize available evidence on the extent of malaria and soil-transmitted intestinal helminth (STH) co-infections in people living in endemic countries and to explore the effect of interactions between malaria and STHs on anemia...

On the Effects of Malaria Treatment on Parasite Drug Resistance – Probability Modelling of Genotyped Malaria Infections [The International Journal of Biostatistics] — (English)
We compare the frequency of resistant genes of malaria parasites before treatment and at first malaria incidence after treatment...

Naturally Acquired Antibodies Specific for Plasmodium falciparum RH5 Inhibit Parasite Growth and Predict Protection From Malaria [J Infect Dis. (2013) doi: 10.1093/infdis/jit553] — (English)
We assessed pre-malaria season PfRH5-specific IgG levels in 357 Malian children and adults who were uninfected with Plasmodium...

IFN-γ–Induced Priming Maintains Long-Term Strain-Transcending Immunity against Blood-Stage Plasmodium chabaudi Malaria [The Journal of Immunology October 16, 2013 1300462] — (English)
n this study, we investigated whether IFN-γ–induced priming is important to maintain long-term protective immunity against Plasmodium chabaudi AS malaria...

Thymine distribution in genes provides novel insight into the functional significance of the proteome of the malaria parasite Plasmodium falciparum 3D7 [Bioinformatics (2013) doi: 10.1093/bioinformatics/btt587] — (English)
The identification of these proteins could open new pivotal drug-targeting avenues...

Development of a capillary electrophoresis-based heteroduplex tracking assay to measure in-host genetic diversity of initial and recurrent Plasmodium vivax infections in Cambodia [JCM.02274-13] — (English)
This new assay achieved good allelic discrimination and detected a high multiplicity of infection in 63 P. vivax infections from Cambodia...

AUTOCHTHONOUS FALCIPARUM MALARIA POSSIBLY TRANSMITTED BY LUGGAGE-CARRIED VECTOR IN PARIS, FRANCE, FEBRUARY 2013 [Eurosurveillance, Volume 18, Issue 40, 03 October 2013] — (English)
We report a case of autochthonous falciparum malaria in a patient in Paris, France, in February 2013 who reported no recent travel to malaria-endemic countries. The parasite, Plasmodium falciparum, was possibly transmitted by an infective Anopheles mosquito carried in baggage from a malaria-endemic area...

Plasmodium falciparum malaria recrudescence occurring 2.5 years after leaving an endemic country [Neth J Med. 2013 Oct;71(8):426-8] — (English)
We present here a male patient with severe P. falciparum malaria diagnosed 2.5 years after returning from Burkina-Faso...

Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate [J. Antimicrob. Chemother. (2013) doi: 10.1093/jac/dkt394] — (English)
This review shows that: (i) the folate supplementation effect on antifolate efficacy is dose-dependent, and folic acid doses required to protect pregnant women from NTDs will not decrease antifolate activity; and (ii) 5-methyl-tetrahydrofolate, the predominant form of folate in the blood circulation, could be administered (even at high dose) concomitantly with antifolate without affecting antifolate efficacy. Thus, strategies exist to protect pregnant women from malaria while maintaining adequate folate levels in the body to reduce the occurrence of NTDs....

MBL2 variations and malaria susceptibility in Indian populations [IAI.01041-13] — (English)
We aim to investigate the contribution of functional MBL2 gene variations with P. falciparum malaria in well-defined cases and in matched controls...

Cross-Reactive Immune Responses as Primary Drivers of Malaria Chronicity [IAI.00958-13] — (English)
We developed a model to examine the role of cross-reactivity in generating infection dynamics that are comparable to experimental infections...

Erythropoietin Protects against Murine Cerebral Malaria through Actions on Host Cellular Immunity [IAI.00929-13] — (English)
To elucidate the mechanism of EPO in this ECM model, we investigated the effect of rhEPO on host cellular immune responses...

A bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite neutralizing antibodies [IAI.00970-13] — (English)
Here, we have produced full-length recombinant PfRH5 in Escherichia coli that exhibits specific erythrocyte binding similar to that of the native PfRH5 parasite protein and also importantly elicits potent invasion inhibitory antibodies against a number of P. falciparum strains...

The Impact of Malaria in Pregnancy on Changes in Blood Pressure in Children During Their First Year of Life [HYPERTENSIONAHA.113.02238] — (English)
We established a maternal birth cohort in Ibadan, Nigeria, where malaria is hyperendemic, to assess how intrauterine exposure to malaria affected infant blood pressure (BP) development. In a local maternity hospital, healthy pregnant women had regular blood films for malaria parasites from booking to delivery...

A specific inhibitor of PfCDPK4 blocks malaria transmission: Chemical-genetic validation [J Infect Dis. (2013) doi: 10.1093/infdis/jit522] — (English)
Here, we report the pharmacological characterization of a new class of malaria transmission-blocking compounds that acts via the inhibition of Plasmodia CDPK4 enzyme...

Expression of Functional Plasmodium falciparum Enzymes using a Wheat Germ Cell-free System [EC.00222-13] — (English)
We tested the general utility of cell-free systems for expressing malaria enzymes...

A Realistic Host-Vector Transmission Model for Describing Malaria Prevalence Pattern [Bull Math Biol. 2013 Oct 12] — (English)
In this paper, a general mathematical model of malaria transmission is developed considering short and long-term age-dependent immunity of human host and its interaction with pathogen-infected mosquito vector...

Dispersal in a patchy landscape reveals contrasting determinants of infection in a wild avian malaria system [Issue Cover image for Vol. 82 Issue 5 Journal of Animal Ecology] — (English)
Here, using a six-year longitudinal dataset from a spatially referenced population of blue tits, we test the extent to which infection by avian malaria parasites is determined by conditions experienced at natal or breeding sites, as well as by postnatal dispersal between the two...