28.10.2013

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Announcements / Press Releases

Malaria Fight Needs OIC Support [RBM] — (English)
The Organization of the Islamic Cooperation held its 4th session of the Islamic Conference of Health Ministers. Malaria figured squarely on the agenda of the conference, with a panel discussion on malaria eradication. Successful examples of malaria control and elimination in OIC states were showcased, including Turkey, Morocco, and Mozambique...

RBM Goodwill Ambassador Yvonne Chaka Chaka Honored in South Africa and Washington, D.C. for Humanitarian Work [RBM] — (English)
On Wednesday evening, 23 October, H.E. Ms Amina S. Ali, Ambassador of the African Union to the U.S., and the Roll Back Malaria Partnership (RBM) co-hosted, in partnership with Diplomatic Connections magazine, a private dinner to honor South African singer and RBM Goodwill Ambassador Yvonne Chaka Chaka for her work against malaria. The dinner, held at the Fairmont Hotel in Washington, D.C., drew an intimate gathering of African Ambassadors to the U.S...

Roll Back Malaria Partnership - Development of a Second Generation GMAP [RBM] — (English)
The RBM Partnership is seeking proposals from suitably qualified organisations and consortiums to undertake work in developing the next generation of the Global Malaria Action Plan (GMAP). Proposals must be received no later than Monday 25 November 2013, 12:00 hours, Geneva time to be considered. Download RFP...

PATH Malaria Vaccine Initiative names new director [PATH press release] — (English)
Ashley Birkett, PhD, to lead key product development program at PATH...

Grant to Fight Malaria Crisis in Central African Republic [The Global Fund press release] — (English)
With the Central African Republic facing conflict and instability, the Global Fund to Fight AIDS, Tuberculosis and Malaria and the International Federation of Red Cross and Red Crescent Societies (IFRC) have signed a grant agreement to combat a malaria crisis gripping the country...

Tahir Contributes $65 Million to the Global Fund [The Global Fund press release] — (English)
Dato Sri Dr. Tahir, Chairman of the Tahir Foundation in Indonesia, announced today that his foundation is investing US$65 million in the Global Fund to Fight AIDS, Tuberculosis and Malaria. The contribution is being matched by the Bill & Melinda Gates Foundation, for a total US$130 million investment in the Global Fund...

MMV: Senior Legal Officer [MMV] — (English)
Application deadline: 31 October 2013...

Senior Program Officer, Vector Control (Malaria) [BM Gates Foundation] — (English)
The Malaria Program Strategy Team (PST) is recruiting a Senior Program Officer to strategically develop and manage a portfolio of complex investments requiring high-level grant management skills, monitoring, and evaluation...

New $25 ASTMH Membership Rate [ASTMH] — (English)
ASTMH Introduces Reduced $25 Membership Rate for Low- and Lower-Middle Income Countries ...

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Articles requiring subscription or registration

Effect of helminth-induced immunity on infections with microbial pathogens [Nature Immunology 14, 1118–1126 (2013) doi:10.1038/ni.2736] — (English)
In this Review we focus on the three main killers in infectious disease—AIDS, tuberculosis and malaria—and critically assesses whether helminths adversely influence host control of these diseases...

Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission [10.1073/pnas.1313965110 PNAS] — (English)
These studies set the stage for further optimization of NSC-158011 for development of a class of dual activity antimalarials to block both intraerythrocytic asexual replication and gametocytogenesis...

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo [PNAS 10.1073/pnas.1312782110 ] — (English)
These findings demonstrate the utility of a purely chemical means to achieve selective drug targeting in vivo. This approach may find useful application in parasitic infections and more broadly in any disease state characterized by aberrant production of reactive ferrous iron...

Eliminating Malaria in the American South: An Analysis of the Decline of Malaria in 1930s Alabama [ American Journal of Public Health] — (English)
We used a Poisson mixture model to analyze the decline of malaria at the county level in Alabama (an archetypical Deep South cotton state) during the 1930s...

Strong larvicidal potential of Artemisia annua leaf extract against malaria (Anopheles stephensi Liston) and dengue (Aedes aegypti L.) vectors and bioassay-driven isolation of the marker compounds [Parasitology Research, October 2013 ] — (English)
This is our first report of strong mortality of A. annua leaf chloroform extract against vectors of two deadly diseases. This technology can be scaled up for commercial exploitation...

Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes [Glycoconjugate Journal, October 2013 ] — (English)
The cotyledon is the only placental tissue accessible to parasites in the bloodstream, suggesting it is the primary receptor for parasite infected red blood cells...

Synergy of ferrous ion on 5-aminolevulinic acid mediated growth inhibition of Plasmodium falciparum [ J Biochem (2013) doi: 10.1093/jb/mvt096 ] — (English)
These novel findings may lead to development of a new antimalarial drug using ALA and Fe2+...

Analyses of genetic variations at microsatellite loci present in-and-around the Pfcrt gene in Indian Plasmodium falciparum [Infection, Genetics and Evolution] — (English)
Data analyses employing different population genetic tests could not straightforwardly explain either the model invoking ‘genetic hitchhiking’ or ‘genetic drift’. However, complex evolutionary models influenced by both demography and natural selection or an alternative model of natural selection (e.g. diversifying/balancing selection) might better explain the observed microsatellite variation in-and-around the pfcrt gene in Indian P. falciparum...

Recent advances in the diagnosis of Plasmodium ovale. Implications of the separation into the two species P. o. wallikeri and P. o. curtisi for diagnosis [http://jcm.asm.org/content/early/2013/10/17/JCM.02760-13.abstract] — (English)
This minireview explores the potential value of innovative methods for the molecular diagnosis of malaria with a strong emphasis on the discrimination and genotyping of P. ovale wallikeri and P. o. curtisi as well as tools for the simultaneous detection of P. ovale sp...

The Periodicity of Plasmodium vivax and Plasmodium falciparum in Venezuela [Acta Tropica] — (English)
We investigated the periodicity of Plasmodium vivax and P. falciparum incidence in time-series of malaria data (1990–2010) from three endemic regions in Venezuela...

A Distinctive Origin and Spread Route of Pyrimethamine-resistant Plasmodium falciparum in Southern China [AAC.00972-13 ] — (English)
By comparative analysis of SNP genotyping and flanking microsatellite haplotypes, we reveal a unique origin of pyrimethamine-resistant mutations in pfdhfr gene in Hainan island, and an oriented spread route of the pyrimethamine resistance from Thailand-Cambodia border into Hainan area, which reflects the geographical traits and SP-administration histories in the two geographically independent areas...

Evidence for Pyronaridine as a Highly Effective Partner Drug for the Treatment of Artemisinin-Resistant Malaria in a Rodent Model [AAC.01466-13 ] — (English)
Here, we demonstrate that the rodent Plasmodium berghei SANA strain has acquired artemisinin resistance following drug pressure, as defined by reduced parasite clearance and early recrudescence following daily exposure to high doses of artesunate or the active metabolite dihydroartemisinin...

Prevalence of polymorphisms in antifolate drug resistant molecular marker genes, pvdhfr and pvdhps in clinical isolates from Kolkata, India [AAC.01171-13] — (English)
We studied the prevalence of point mutations and haplotypes of both the genes in 80 P. vivax isolates collected from urban Kolkata by DNA sequencing method...

Effect of mature, blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria [IAI.00705-13 ] — (English)
Our work provides evidence that schizont sequestration could be a major biological process driving rapid, early increases in parasite biomass during blood-stage Plasmodium infection...

Novel anti-Plasmodial hits identified by virtual screening of the ZINC database [Journal of Computer-Aided Molecular Design, October 2013 ] — (English)
These results identify novel classes of antimalarials that are structurally different from those currently in use and which can be further derivatized to deliver leads suitable for optimisation...

Clinical Pharmacokinetic Drug Interactions Associated with Artemisinin Derivatives and HIV-Antivirals [Journal of Computer-Aided Molecular Design, October 2013] — (English)
Despite several limitations to the studies, these data do provide valuable insights into the potential pharmacokinetic perturbations, and the consistently marked elevation or reduction in ACT exposure in some cases cannot be overlooked....