25.11.2013

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Announcements / Press Releases

Government of Côte d'Ivoire hosts 25th RBM Board meeting [RBM] — (English)
Her Excellency the Minister of Health Dr Raymonde Goudou Coffie opened the 25th RBM Board meeting in Abidjan, Côte d'Ivoire on Wednesday, highlighting malaria control as a priority intervention to overcome the socio-political crisis in her country...

Mary and Martha... and Malaria [RBM] — (English)
The Roll Back Malaria Partnership welcomed acclaimed UK film writer and director, Mr. Richard Curtis, to Geneva to screen his film, Mary and Martha, which chronicles the epic journey of two mothers tragically affected by malaria and united in their resolve to combat the disease at home and abroad...

Republic of Korea Boosts Contribution to Global Fund [The Global Fund] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria welcomed an announcement by the Republic of Korea to double its contribution to the Global Fund over the next three years by drawing on the proceeds of a levy on airline tickets...

WHO informal consultation on fever management in peripheral health care settings: A global review of evidence and practice [WHO] — (English)
WHO has released a new report entitled WHO informal consultation on fever management in peripheral health care settings: A global review of evidence and practice. The report is the result of a technical consultation held in January 2013 by the WHO Global Malaria Programme and the Special Programme for Research and Training in Tropical Diseases. It reviews evidence and operational experiences regarding the correct management of febrile illnesses in primary health care facilities and at the community level, and considers existing WHO guidance and research priorities...

Roll Back Malaria Partnership – Development of a Second Generation GMAP [RBM] — (English)
RBM Partnership is seeking proposals from suitably qualified organisations and consortiums to under work in developing the next generation of the Global Malaria Action Plan (GMAP). Proposals must be received no later than Monday 25 November 2013, 12:00 hours, Geneva time to be considered...

Consultancy: RBM Advocacy Resource Mobilization for Malaria (ARMM) Toolkit [RBM] — (English)
Application Deadline: 25 November 2013......

University of Oxford - Department of Zoology: Senior Postdoctoral Modeller [University of Oxford] — (English)
Application Deadline: 29 November 2013...

Consultancy positions under RETA 8485: Fighting HIV/AIDS, Malaria and Other Communicable Diseases in Asia and the Pacific [APLMA] — (English)
Application deadline extended: 29 November 2013...
APLMA Regional Executive Secretary
APLMA Regional Deputy Executive Secretary
APLMA Team Leader for Taskforce on Access to Quality Medicines and Other Technologies for Malaria in the Asia-Pacific
APLMA Team Leader for Task Force on Regional Financing

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Articles requiring subscription or registration

Advancing social and economic development by investing in women's and children's health: a new Global Investment Framework [The Lancet, doi:10.1016/S0140-6736(13)62231-X] — (English)
A new Global Investment Framework for Women's and Children's Health demonstrates how investment in women's and children's health will secure high health, social, and economic returns. We costed health systems strengthening and six investment packages for: maternal and newborn health, child health, immunisation, family planning, HIV/AIDS, and malaria...

Malaria vaccine technology roadmap [The Lancet, Volume 382, Issue 9906, Pages 1700 - 1701, doi:10.1016/S0140-6736(13)62238-2] — (English)
Despite the major public health effect of the scale-up of available control measures, malaria remains the largest single cause of child mortality in many settings in Africa...

Single low-dose primaquine to reduce malaria transmission [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(13)70288-3] — (English)
The WHO Evidence Review Group's August, 2012 report about the safety and effectiveness of a single dose of primaquine as a Plasmodium falciparum gametocytocide 1 and WHO's new policy recommendation about low-dose primaquine generated much interest for malaria control programmes seeking additional methods to reduce malaria transmission, especially in settings in which elimination of malaria is pursued...

Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(13)70268-8] — (English)
Our findings call for the prioritisation of further trials into the efficacy and safety of doses of primaquine between 0·1 mg/kg and 0·4 mg/kg (including the dose of 0·25 mg/kg recently recommended by WHO), in view of the potential for widespread use of the drug to block malaria transmission...

Malaria life cycle intensifies both natural selection and random genetic drift [PNAS] — (English)
We hypothesized that these patterns might result from the repeated bottlenecks in host–vector and vector–host transmission as well as the intense competition between parasites within a single host...

Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae [PNAS] — (English)
Results suggest that hybrids suffer a fitness disadvantage, but at least some hybrid genotypes are viable. Stable introgression of the 2L speciation island occurred at one site following a hybridization event...

Decreased growth rate of P. falciparum blood stage parasitemia with age in a holoendemic population [J Infect Dis. (2013) doi: 10.1093/infdis/jit613] — (English)
Here we analyse the dynamics of Plasmodium falciparum infection after treatment in a cohort of 197 healthy study participants of different age...

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection [J Infect Dis. (2013) doi: 10.1093/infdis/jit618] — (English)
Genome-wide polymorphism analysis of an endemic population sample robustly identifies loci with detailed documentation of recent selection, demonstrating power to prospectively detect emerging drug resistance genes...

DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families [Nucl. Acids Res. (2013) doi: 10.1093/nar/gkt1174] — (English)
By experimental and bioinformatic identification of recombination events and genome-wide recombination hotspots in var genes, we show that during the parasite’s sexual stages, ectopic recombination between isogenous var paralogs occurs near low folding free energy DNA 50-mers and that these sequences are heavily concentrated at the boundaries of regions encoding individual Plasmodium falciparum-erythrocyte membrane protein 1 structural domains...

Modelling the time course of antimalarial parasite killing: A tour of animal and human models, translation and challenges [British Journal of Clinical Pharmacology] — (English)
This review summarises the PK-PD characterisation of artemisinin derivatives and other partner drugs from both preclinical studies and human clinical trials...

Anti-apicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the Malaria Box [AAC.01500-13] — (English)
The Malaria Box is a collection of 400 commercially available chemical entities having antimalarial activity. The collection contains 200 drug-like compounds, based on their oral absorption and the presence of known toxicophores, and 200 probe-like compounds, which are intended to represent a broad structural diversity...

Antimalarial Efficacy of Hydroxyethylapoquinine (SN-119) and Derivatives [AAC.01704-13] — (English)
Here we describe synthesis of HEAQ and its novel stereoisomer hydroxyethylapoquinidine (HEAQD) along with two intermediates hydroxyethylquinine (HEQ) and hydroxyethylquinidine (HEQD) and demonstrate their comparable but elevated antimalarial inhibition concentration 50% (IC50) of 100-200 nM against Plasmodium falciparum quinine sensitive 3D7 (IC50-56 nM)...

Plasmodium falciparum picks (on) EPCR [Blood, 2013 blood-2013-09-521005] — (English)
Malaria-associated depletion of EPCR, with subsequent impairment of the protein C system promotes a pro-inflammatory, procoagulant state in brain microvessels...

Malaria elimination: needs assessment and priorities for the future [J Infect Dev Ctries. 2013 Nov 15;7(11):769-80. doi: 10.3855/jidc.3079] — (English)
This review addresses a number of research priorities in the present stage of the fight against malaria...

Copper-transporting ATPase is important for malaria parasite fertility [Molecular Microbiology] — (English)
A cross-fertilization assay demonstrated that female fertility was also severely abrogated. In conclusion, we provide experimental genetic and pharmacological evidence that a healthy copper homeostasis is critical to malaria parasite fertility of both genders of gametocyte and, hence, to transmission to the mosquito vector...