02.12.2013

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Announcements / Press Releases

Malaria forum for the private sector in Myanmar [RBM] — (English)
The first-ever Myanmar Malaria Forum to engage the corporate sector was held in Yangon. Two-thirds of the more than 130 participants represented the private sector to discuss actionable steps to assist in reducing and treating malaria infections, with a focus on addressing emerging cases of malaria infections resistant to treatment...

Partners commit to bolstering open source research [MMV] — (English)
MMV, DNDi and RSC sign MoU to foster a global community of open source drug discovery researchers...

Malaria vaccine offers new mode of protection against disease [Oxford University] — (English)
A novel malaria vaccine developed at Oxford University has shown promising results in the first clinical trial to test whether it can protect people against the mosquito-borne disease...

New malaria target identified with potential to prevent, block, and treat multiple stages of the malaria life cycle [Novartis Press release] — (English)
Novartis scientists have discovered a new drug target for treating malaria. The discovery, which is published online in the journal Nature,2 identifies phosphatidylinositol-4 kinase (PfPI4K) as the target of the imidazopyrazines, a novel experimental antimalarial compound class that inhibits the development of multiple malaria-causing Plasmodium species at each stage of infection in the human host...

Parasite lost [UC] — (English)
Using advanced methodologies that pit drug compounds against specific types of malaria parasite cells, an international team of scientists, including researchers at the University of California, San Diego School of Medicine and the Genomics Institute of the Novartis Research Foundation, have identified a potential new weapon and approach for attacking the parasites that cause malaria...

Global Fund Results Show Strong Momentum [The Global Fund press release] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria announced new results today that show a substantial increase in the number of people being treated for HIV, in the distribution of insecticide-treated nets to combat malaria and in treatment for TB...

Study of decline of malaria in the U.S. could affect approach to malaria epidemic abroad, UT Arlington researcher says [Universiry of Texas] — (English)
A new UT Arlington study about the elimination of malaria in the 1930s American South may have significant implications for solving modern day malaria outbreaks in parts of Africa, Central and Latin America and Asia...

MNM Benefit Honors Hillary Clinton, Raises over $1M [MNM] — (English)
Secretary Clinton celebrated recent progress in the malaria fight, and emphasized the critical role of malaria treatment in her speech: “The distribution of life-saving drugs has been a total life-saving, game-changing event for so many families and their children,” she said. “A treatment costs only one dollar to buy and deliver to a child, as Malaria No More’s Power of One campaign has shown.”...

NATIONAL MALARIA PROGRAMME-PERFORMANCE REVIEW [RBM] — (English)
Aide memoire, October 2013...

PSI: Senior Research Advisor, ACTwatch [PSI] — (English)
PSI seeks qualified candidates to fill the role of Senior Research Advisor for the ACTwatch Research Project...

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Articles requiring subscription or registration

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation [Nature Communications] — (English)
Here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus Ankara booster induces exceptionally high frequency T-cell responses (median >2400 SFC/106 peripheral blood mononuclear cells) to the liver-stage Plasmodium falciparum malaria antigen ME-TRAP...

Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum [Nature Communications doi:10.1038/ncomms3862] — (English)
Here we show that monoclonal antibodies against PfRH1 (an RH) block merozoite invasion by specifically inhibiting calcium signalling in the parasite, whereas invasion-inhibiting monoclonal antibodies targeting EBA175 (an EBL protein) have no effect on signalling...

Targeting Plasmodium PI(4)K to eliminate malaria [ Nature (2013) doi:10.1038/nature12782] — (English)
Collectively, our data define PI(4)K as a key Plasmodium vulnerability, opening up new avenues of target-based discovery to identify drugs with an ideal activity profile for the prevention, treatment and elimination of malaria...

Maurer's clefts, the enigma of Plasmodium falciparum [PNAS 10.1073/pnas.1309247110 ] — (English)
In this perspective we review the most important findings and conclude with potential possibilities to shed light into the enigma of Maurer’s clefts. Understanding the mechanism and function of these structures, as well as their involvement in protein export in P. falciparum, might lead to innovative control strategies and might give us a handle with which to help to eliminate this deadly parasite...

The challenges of malaria elimination [The Lancet, Volume 382, Issue 9906, Page 1700, 23 November 2013 ] — (English)
Chris Cotter and colleagues1 discuss interventions promoting changes in receptivity to malaria transmission. If health professionals harness the synergies between the environment and health, they have a chance to change the receptivity of our future environment to malaria and tackle several issues simultaneously...

The challenges of malaria elimination [The Lancet, Volume 382, Issue 9906, Pages 1699 - 1700, 23 November 2013 ] — (English)
We share Chris Cotter and colleagues' (Sept 7, p 900)1 concerns regarding the challenges ahead in strategic research for malaria control; however, we believe several issues demand closer attention, especially within historical context...

Conservation Efforts and Malaria in the Brazilian Amazon [Am J Trop Med Hyg 2013 13-0323 ] — (English)
We respond to Valle and Clark, who assert that “conservation efforts may increase malaria burden in the Brazilian Amazon,” because the relationship between forest cover and malaria incidence was stronger than the effect of the deforestation rate...

Needs for Monitoring Mosquito Transmission of Malaria in a Pre-Elimination World [Am J Trop Med Hyg 2013 13-0175] — (English)
As reported in this workshop summary, a recent gathering of medical entomologists, modelers, and malaria experts reviewed these issues and agreed that efforts are needed to improve methods to monitor key transmission parameters. Identified needs include standardized methods for sampling of both mosquito adults and larvae, improved tools for mosquito species identification, and age-grading and a better means for determining the entomological inoculation rate...

Taking a Bite Out of Mosquitoes: A New Drug to Block Transmission of Malaria [ Infect Dis. (2013) doi: 10.1093/infdis/jit523] — (English)
Despite concerted control efforts and decades of research, malaria remains a global scourge and the most important parasitic disease of humans. Infections caused by the parasite Plasmodium falciparum exact a huge toll, largely in sub-Saharan Africa, where nearly a million children die annually from complications of malaria...

Low antibody levels to pregnancy-specific malaria antigens and heightened cytokine responses associated with severe malaria in pregnancy [ J Infect Dis. (2013) doi: 10.1093/infdis/jit646 ] — (English)
Pregnant women with SM lack pregnancy-specific malaria immunity, and this correlates with heightened inflammatory cytokine concentrations, low haemoglobin levels and high parasite density, suggesting that failure of antibody to control parasitaemia may contribute to SM pathogenesis...

Malaria Infection Alters the Expression of Hepatobiliary and Placental Drug Transporters in Pregnant Mice [Drug Metab Dispos. doi: 10.1124/dmd.113.053983 ] — (English)
Together, malaria- induced alterations in the expression of transporters and drug-metabolizing enzymes in maternal and fetal tissues may alter the disposition of endogenous and therapeutic substrates, potentially impacting maternal and fetal outcomes...

Inhibitor of Cysteine Proteases Is Critical for Motility and Infectivity of Plasmodium Sporozoites [mBio doi: 10.1128/mBio.00874-13] — (English)
This study is the first genetic evidence that an ICP is necessary for the productive motility of a eukaryotic parasitic cell...

Diversity, Differentiation and Linkage Disequilibrium: Prospects for Association Mapping in the Malaria Vector, Anopheles arabiensis [ G3 g3.113.008326 ] — (English)
The overall low levels of linkage disequilibrium suggests that association studies in this taxon will be very challenging for all but variants of large effect, and will require large sample sizes...

Le rôle des microvésicules dans l’infection palustre [Med Sci (Paris) Volume 29, Numéro 11, Novembre 2013 ] — (French)
Role of microvesicles in malaria infections...

In vivo antimalarial evaluation of MAMA decoction on Plasmodium berghei in mice [Parasitology Research] — (English)
The study has evaluated the antimalarial efficacy of MAMA decoction (MD), a multicomponent herbal preparation and its individual plant components, namely leaves of Morinda lucida Benth [Rubiaceae] (ML), Azadirachta indica A. Juss [Meliaceae] (AI), Alstonia boonei De Wild [Apocynaceae] (AB) and Mangifera indica L [Anacardiaceae] (MI) in Plasmodium berghei-infected mice...