09.12.2013

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Announcements / Press Releases

RBM Partnership congratulates donors for their commitment to replenish the Global Fund [RBM] — (English)
The Roll Back Malaria Partnership welcomes the pledges announced at the fourth replenishment conference of the Global Fund to fight AIDS, Tuberculosis and Malaria held in Washington on December 3...

Global Fund Donors Pledge US$12 Billion [The Global Fund] — (English)
Donors at the launch of the Global Fund’s Fourth Replenishment today pledged US$12.0 billion for the next three years, the largest amount ever committed to fight against AIDS, tuberculosis and malaria...

Swiss Capital shows SMG Malaria Photo Exhibit [RBM] — (English)
The Swiss Malaria Group (SMG) presents its 2013 landmark malaria photo exhibition in the Swiss Capital from December 3 to 5. The exposition is supported by the Bern municipal council and sponsored by the 17 members that form the SMG, including the Swiss Agency for Development and Cooperation (SDC) within the Federal Department of Foreign Affairs. The aim of the Swiss Malaria Group is to raise awareness of malaria and its impacts among decision makers and the public and to increase Swiss support for organisations that are actively involved in the fight against malaria...

Country Preparation for the Global Fund NFM Workshop [RBM] — (English)
The Harmonization Working Group convened endemic country representatives in Nairobi, from December 2 to 6, to prepare them for the Global Fund New Funding Modality (NFM) that will be launched in 2014...

Training module on malaria control: Epidemiological approach for malaria control. Second Edition [WHO] — (English)
The planning and implementation of a malaria control programme must be based on epidemiological analysis, selection and application of interventions suitable to the local malaria situation. This training module on epidemiological approach for malaria control has been developed by WHO to improve the capacity of managers and other health professionals of malaria control programmes in understanding the key determinants of malaria epidemiology, and their interactions, as the basis for the selection of appropriate prevention and control interventions. The module can be used both for in-service training programmes and pre-service training of health workers...

Germany Voices Consistent Support for the Global Fund [The Global Fund] — (English)
At the Global Fund’s Fourth Replenishment Conference, a video message from Chancellor Angela Merkel of Germany voiced strong support for efforts to raise funds needed to defeat AIDS, TB and malaria...

Global Fund Welcomes Japan’s Strong Contribution [The Global Fund] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria welcomed the announcement today by the Government of Japan of a contribution of US$800 million over the coming years, underscoring its strong and sustained commitment to the Global Fund...

Rise in R&D funding could set stage for malaria eradication by providing new drugs, vaccines, insecticides, and diagnostics [MVI press release] — (English)
Report hails recent progress in reducing malaria illnesses and deaths, but warns new tools needed to fight emerging drug and insecticide resistance...
Read the report FROM PIPELINE TO PRODUCT: MALARIA R&D FUNDING NEEDS INTO THE NEXT DECADE


PSI: Senior Research Advisor, ACTwatch [PSI] — (English)
PSI seeks qualified candidates to fill the role of Senior Research Advisor for the ACTwatch Research Project...

MCDi: EGMVI Malaria Vaccine Project Specialist [Equatorial Guinea Malaria Vaccine Initiative (EGMVI)] — (English)
Read Position Announcement...

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Articles requiring subscription or registration

Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae [PNAS] — (English)
The discovered genes and single-nucleotide polymorphisms are anticipated to be useful in the development of tools for malaria control in endemic areas in Africa...

RH5–Basigin interaction plays a major role in the host tropism of Plasmodium falciparum [PNAS] — (English)
Consistent with the essential role of the PfRH5–BSG interaction in erythrocyte invasion, we conclude that species-specific differences in the BSG receptor provide a molecular explanation for the restriction of P. falciparum to its human host...

Straight talk with...BT Slingsby [Nature Medicine 19, 1553 (2013) doi:10.1038/nm1213-1553] — (English)
In November, the Tokyo-based fund announced its first round of awards totaling $5.7 million. The six grants will go to partnerships aimed at developing new drugs and vaccines to fight malaria, tuberculosis and Chagas disease, a neglected disease endemic to Latin America...

Does a significant reduction in malaria risk make lopinavir/ritonavir-based ART cost-effective for children with HIV in co-endemic, low-resource settings? [Trans R Soc Trop Med Hyg (2013) doi: 10.1093/trstmh/trt108] — (English)
Our model suggests a unit cost of US$147 per DALY gained for the LPV/r-based group compared to US$37 per DALY gained for the NNRTI-based group...

Feasibility, safety and effectiveness of combining home based malaria management and seasonal malaria chemoprevention in children less than 10 years in Senegal: a cluster-randomised trial [Trans R Soc Trop Med Hyg (2013) doi: 10.1093/trstmh/trt103] — (English)
This study assessed the feasibility, effectiveness and safety of combining SMC and HMM delivered by community health workers (CHWs)...

Neutralization of Plasmodium falciparum Merozoites by Antibodies against PfRH5 [The Journal of Immunology] — (English)
In this study, we report that vaccine-induced polyclonal anti-PfRH5 Abs inhibit the tight attachment of merozoites to erythrocytes and are capable of blocking the interaction of PfRH5 with its receptor basigin...

Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes [EC.00264-13] — (English)
Using antibodies, we find that the FAS-II enzyme FabI is expressed in mosquito midgut oocysts and sporozoites as well as liver stage parasites but not during the blood stages...

Artesunate–amodiaquine combination therapy in the absence of malarial parasite infection induces oxidative damage in female rats [Cell Biochemistry and Function] — (English)
Our aim was to evaluate clinical routine markers of liver and renal functions, lipid profile levels and lipid peroxidation status in a female mammalian rat model...

Crystal structure of Plasmodium vivax FK506 binding protein 25 reveals conformation changes responsible for its non-canonical activity [Proteins: Structure, Function, and Bioinformatics] — (English)
Here we present the biochemical characterization and 1.9Å crystal structure of an N-terminal truncated FKBP25 from Plasmodium vivax (PvFKBP2572-209)...

Analysis of Human B cell Responses following ChAd63-MVA MSP1 and AMA1 Immunization and Controlled Malaria Infection [Immunology] — (English)
Here we analysed human B cell responses in a series of Phase I/IIa clinical trials, which include CHMI, using candidate viral vectored vaccines encoding two blood-stage antigens – merozoite surface protein 1 (MSP1) and apical membrane antigen 1 (AMA1)...

Association of inconclusive sera for human immunodeficiency virus infection with malaria and Epstein-Barr virus infection in Central Africa [JCM.02945-13] #151; (English)
n Central Africa, inconclusive sera for HIV are frequently associated with malaria, EBV infection or both...

Draft Genome Sequences of Elizabethkingia anophelis Strains R26T and Ag1 from the Midgut of the Malaria Mosquito Anopheles gambiae [Genome Announce doi: 10.1128/genomeA.01030-13 ] — (English)
We present the draft genome sequences of two strains of E. anophelis, R26T and Ag1, which were isolated from the midgut of the malaria mosquito Anopheles gambiae...

Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium [Curr Bioinform. 2012 December 1; 7(4): 10.2174/157489312803900965] — (English)
In this review, we survey omics centered developments in Plasmodium biology, which have set the stage for a quantum leap in our understanding of the fundamental processes of the parasite life cycle and mechanisms of drug resistance and immune evasion...

On the birefringence of healthy and malaria-infected red blood cells [Journal of Biomedical Optics | Volume 18 | Issue 12] — (English)
We demonstrate the possibility of using birefringence to establish very early stages of infected parasites and of assessing various factors that contribute to birefringence in normal and infected cells. Our results have implications for the development and use of noninvasive techniques of quantifying changes in cell properties induced by malaria disease pathology...

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infectio [J Clin Invest.] — (English)
These data indicate that RTS,S-induced antibodies are protective and provide sterilizing immunity against P. falciparum infection when reaching or exceeding a critical plasma concentration...