16.12.2013

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Announcements / Press Releases

World malaria report 2013 shows major progress in fight against malaria, calls for sustained financing [WHO press release] — (English)
Global efforts to control and eliminate malaria have saved an estimated 3.3 million lives since 2000, reducing malaria mortality rates by 45% globally and by 49% in Africa, according to the "World malaria report 2013" published by WHO...
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Putting malaria treatment in the hands of communities [WHO] — (English)
A project run by the WHO Malaria Programme with a grant from the Government of Canada seeks to reduce deaths in children under 5 years of age living in remote rural areas...

Beating Malaria: We Must Win This Fight [Dionote] — (English)
Blog by John Kerry...

Countries seek improvements in malaria tests [RBM] — (English)
At a meeting jointly organized by the Roll Back Malaria Partnership and the Institute of Tropical Medicine in Antwerp, manufacturers and implementers of rapid diagnostic tests (RDTs), used to diagnose malaria at the point of care, agreed on a set of required features for RDTs in an effort to improve use and boost the scale up of malaria testing...

Die Schweiz verstärkt ihr Engagement im Kampf gegen Malaria, HIV/AIDS und Tuberkulose [Schweizerische Eidgenossenschaft] — (German)
Der Bundesrat genehmigt für die Zeitperiode 2014-2016 einen Beitrag von 60 Millionen Franken an den Globalen Fonds zur Bekämpfung von HIV/AIDS, Tuberkulose und Malaria (GFATM). Die Schweiz war 2002 Mitbegründerin des Fonds, der seinen Sitz in Genf hat, und ist seit den Anfängen eine wichtige Partnerin. Malaria, Tuberkulose und HIV/AIDS sind nach wie vor die wichtigsten Todesursachen in den Ländern südlich der Sahara. Die drei Krankheiten zählen zu den wesentlichen entwicklungshemmenden Faktoren...

UCSF Receives $15 Million for Malaria Elimination Campaign [University of California - San Francisco News] — (English)
UC San Francisco’s Global Health Group has received a $15 million grant from the Bill & Melinda Gates Foundation for a pioneering effort to help nearly three dozen countries eliminate malaria within their borders...

PSI: Senior Research Advisor, ACTwatch [PSI] — (English)
PSI seeks qualified candidates to fill the role of Senior Research Advisor for the ACTwatch Research Project...

MCDi: EGMVI Malaria Vaccine Project Specialist [MCDi] — (English)
Job description...

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Articles requiring subscription or registration

GSK plows ahead with EMA malaria vaccine submission [Nature Biotechnology 31, 1066 (2013) doi:10.1038/nbt1213-1066a] — (English)
On October 8, GlaxoSmithKline and the PATH Malaria Vaccine Initiative (MVI) released 18-month data from a phase 3 trial of the RTS,S malaria vaccine. Although the vaccine has shown mediocre efficacy and its effect declines over time, it is still expected to become the first malaria vaccine...

Coinfection with Plasmodium falciparum and Schistosoma haematobium: Additional Evidence of the Protective Effect of Schistosomiasis on Malaria in Senegalese Children [Am J Trop Med Hyg 2013 12-0431] — (English)
Our objective was to undertake a study to explore the influence of the measure of excreted egg load caused by Schistosoma haematobium on Plasmodium falciparum parasite densities...

Larvivorous fish for preventing malaria transmission [The Cochrane Library] — (English)
Our main objective was to evaluate whether introducing larvivorous fish to anopheline breeding sites impacts Plasmodium parasite transmission. Our secondary objective was to summarize studies evaluating whether introducing larvivorous fish influences the density and presence of Anopheles larvae and pupae in water sources, to understand whether fish can possibly have an effect...

Mass drug administration for malaria [The Cochrane Library] — (English)
Objectives: To assess the impact of antimalarial MDA on population asexual parasitaemia prevalence, parasitaemia incidence, gametocytaemia prevalence, anaemia prevalence, mortality and MDA-associated adverse events...

Influence of Plasmodium vivax malaria on the relations between the osmotic stability of human erythrocyte membrane and hematological and biochemical variables [Parasitology Research] — (English)
This study evaluated the influence of infection by Plasmodium vivax on the relations between hematological and biochemical variables and the osmotic stability of the erythrocyte membrane in a Brazilian Amazon population...

Insight into the pathogenesis of fetal growth restriction in placental malaria: decreased placental glucose transporter-1 expression [J Infect Dis. (2013) doi: 10.1093/infdis/jit803] — (English)
Placental malaria (PM), especially when complicated with intervillositis (IV), can cause fetal growth restriction (FGR). Transplacental glucose transport by glucose transporter 1 (GLUT-1) on the syncytiotrophoblast microvillous (MVM) and basal (BM) plasma membranes regulates fetal growth...

Cord blood Vγ2 Vδ2 T cells provide a molecular marker for the impact of pregnancy-associated malaria on neonatal immunity [J Infect Dis. (2013) doi: 10.1093/infdis/jit802] — (English)
Our results suggest that PM affects phenotype and repertoire of neonatal Vγ2 Vδ2 lymphocytes. PM may lower the capacity for subsequent Vγ2 Vδ2 cell responses and impair natural resistance to infectious diseases or response to pediatric vaccination...

A model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum [IAI.01249-13] — (English)
Here, we combine passive transfer of monoclonal Abs (mAbs) or immune serum, with a luciferase-expressing Plasmodium yoelii sporozoite challenge to assess Ab-mediated inhibition of liver infection in mice...

Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of falciparum and vivax malaria [IAI.01222-13] — (English)
In this study, we demonstrate that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in malaria endemic countries...

Immunogenicity of a prime-boost vaccine containing the circumsporozoite proteins of Plasmodium vivax in rodents [IAI.01410-13] — (English)
Current measures used to control the transmission of this disease would benefit from the development of an efficacious vaccine. In the case of the deadly parasite P. falciparum, the recombinant RTS,S vaccine containing the circumsporozoite (CSP) antigen consistently protects between 30-50% of human volunteers against infection and is undergoing Phase III clinical trials in Africa with similar efficacy...