20.01.2014

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Announcements / Press Releases

Global Malaria Action Plan 2 (GMAP2) Task Force Meeting [RBM] — (English)
The Global Malaria Action Plan 2 (GMAP2) Task Force met last week to agree on core components of GMAP2, the timeline for its development, and the process to engage outside stakeholders...

A New Framework for Development [The Global Fund news release] — (English)
Mark Dybul, Executive Director of the Global Fund, and Julio Frenk, Dean of the Harvard School of Public Health, said it was time for emerging powers to become fully engaged in the global health dialogue to reflect a new era of partnership based on the principles of shared responsibility and mutual accountability...

Malaria discovery may aid vaccine design [Washington University School of Medicine in St. Louis news release] — (English)
A form of malaria common in India, Southeast Asia and South America attacks human red blood cells by clamping down on the cells with a pair of proteins, new research at Washington University School of Medicine in St. Louis has revealed...

Combating TB, HIV and malaria in detention – Uganda’s experience [ICRC press release and video] — (English)
Morbidity and mortality rates for all three infectious diseases are normally much higher in prisons due to overcrowding, unsanitary conditions and inadequate screening and treatment. This film shows how successful three prisons in Uganda have been in significantly reducing the spread of tuberculosis (TB), HIV and malaria amongst detainees. The pilot health care projects, run by the Ugandan authorities with the support of the ICRC, resulted in significantly increased cure rates of TB, a drop in the number of malaria cases and lower HIV/AIDS mortality rates than in the general population...

New WHO Collaborating Centre in Geospatial Disease Modelling [University of Oxford] — (English)
The University of Oxford has received designation as a World Health Organization (WHO) Collaborating Centre in Geospatial Disease Modelling. Based in the Spatial Ecology and Epidemiology Group (SEEG) in the Department of Zoology, this new designation primarily recognises the contributions of SEEG to supporting the modelling, monitoring and evaluation activities of the WHO Global Malaria Programme...

Resistance gene identified in malaria parasite [Swiss TPH news] — (English)
A molecular marker associated with resistance to malaria treatment is identified this week in Nature. The results may be useful for monitoring and containing resistance, and contribute to eradication efforts. Blaise Genton is a co-author...

How the immune system fights off malaria [MIT News] — (English)
Now, a team led by MIT researchers has developed a strain of mice that mimics many of the features of the human immune system and can be infected with the most common human form of the malaria parasite, known as Plasmodium falciparum. Using this strain, the researchers have already identified a key host defense mechanism, and they believe it should lead to many more useful discoveries...

AMP Statement on M&E Best Practices for Partners Supporting National Long-Lasting ITN Mass Distribution Campaigns [Bestnet] — (English)
In recent months, the Alliance for Malaria Prevention’s (AMP) Emerging Issues working group has been working with its members to draft a statement on M&E Best Practices for Partners Supporting National Long-Lasting ITN Mass Distribution Campaigns. The objective of this statement is to support achieving optimal results through mass campaign distributions by highlighting key monitoring and evaluating (M&E) best practices for partners to endorse and implement. The following recommended best practices reflect the cumulative experiences of the members of the Alliance for Malaria Prevention ...

Bestnet Launches Lifeshelter® - A Completely Novel Approach to Rehousing Problems [Bestnet] — (English)
Bestnet is pleased to announce the official launch of Lifeshelter®, a unique, patent pending rehousing solution for displaced populations, developed by EverShelter ApS. EverShelter ApS is a cooperative partnership between Jakob Christensen, Claus Heding, Bestnet A/S and Innovation Midtvest A/S supported by the Danish Agency for Science, Technology and Innovation...

Malaria Consortium: Malaria Technical Advisor - Malaria Action Programme for States (MAPS) [Malaria Consortium] — (English)
Application Closing Date: 24 January 2014...

RBM: French Media Consultancy [RBM] — (English)
Application Closing Date: 28 January 2014...

President’s Malaria Initiative (PMI): Senior Malaria Advisor, USAID/Burma [PMI] — (English)
Application Closing Date: 31 January 2014...

Coordinator to assist the Ministry of Health and Child Care [CHAI] — (English)
The Clinton Health Access Initiative (CHAI): is seeking a Coordinator to assist the Ministry of Health and Child Care in modeling and implementing optimal, cost-effective strategies for malaria control and elimination...

MMV: Travel Coordinator [MMV] — (English)
Application deadline: 7 February 2014 ...

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Articles requiring subscription or registration

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality [PNAS] — (English)
This study reveals previously unrecognized mechanisms associated with strain-specific malaria infection and provides important information for studying human malaria pathogenesis...

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria [Nature Volume: 505, Pages: 50–55] — (English)
Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain (‘K13-propeller’) with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia...

The Usefulness of Serum C-Reactive Protein and Total Bilirubin Levels for Distinguishing Between Dengue Fever and Malaria in Returned Travelers [Am J Trop Med Hyg 2014 13-0536] — (English)
The clinical manifestations of dengue fever (DF) and malaria are similar. Specific diagnostic tests are not always available. A retrospective study to compare the laboratory results of malaria and DF was conducted at the National Center for Global Health and Medicine in Japan from January of 2005 to March of 2013...

Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection [Am J Trop Med Hyg 2014 13-0655] — (English)
We conducted a preliminary clinical study to assess quinine pharmacokinetics in Malian pregnant women with acute malaria who reported taking nevirapine-based antiretroviral therapy...

Evidence of a Major Reservoir of Non-Malarial Febrile Diseases in Malaria-Endemic Regions of Bangladesh [Am J Trop Med Hyg 2014 13-0487] — (English)
A district-wide prevalence study assessing etiologies of fever in 659 patients recruited in rural and semi-urban areas of Bandarban district in southeastern Bangladesh revealed high proportions of seropositivity for selected infectious diseases (leptospirosis, typhoid fever) potentially being misdiagnosed as malaria because of similarities in the clinical presentation...

Effects of Vivax Malaria Acquired Before 20 Weeks of Pregnancy on Subsequent Changes in Fetal Growth [Am J Trop Med Hyg 2014 13-0285] — (English)
The results suggest that P. vivax infections at an earlier gestational age do not affect umbilical arteries blood flow but do affect fetal biometry in the second trimester of pregnancy and at birth...

Sequence-based Optimization of a Quantitative Real-Time PCR Assay for the Detection of Plasmodium ovale and P. malariae [JCM.03477-13] — (English)
Due to discrepant PCR and microscopy results, we aimed to optimize our detection assays for P. malariae and P. ovale by sequencing the 18S rRNA region and developing a new primer and probe set for real time PCR (qPCR)...

2D and 3D Chromosome Painting in Malaria Mosquitoes [JoVE] — (English)
Chromosome painting is a useful method for studying organization of the cell nucleus and evolution of the karyotype. Here, we demonstrate an approach to isolate and amplify specific regions of interest from single polytene chromosomes that are subsequently used for two- and three-dimensional fluorescent in situ hybridization (FISH)...

Emergence of Plasmodium ovale Malaria among the French Armed Forces in the Republic of Ivory Coast: 20 Years of Clinical and Biological Experience [Clin Infect Dis. (2014) doi: 10.1093/cid/ciu021] — (English)
This emergence of P. ovale malaria enabled a good description to be made in non-immune patients. The lack of sensitivity of both clinical features and quick diagnostic tests is pointed out, suggesting an underestimation...

Exploring Anopheles gut bacteria for Plasmodium blocking activity [Environmental Microbiology] — (English)
We have assessed the midgut colonization capacity of 5 gut bacterial isolates from field-derived, and 2 from laboratory colony, mosquitoes and their effect on Plasmodium development in vivo and in vitro, along with their impact on mosquito survival...

Laboratory evaluation of Fendona 6SC® treated bednets and Interceptor® long-lasting nets against Anopheles gambiae s.l. in Burkina Faso [Parasitology Research] — (English)
In this study, we compared under laboratory conditions, the efficacy of two long-lasting nets (PermaNet® versus Interceptor®) and two treatments kits K-O TAB® (deltamethrin) versus Fendona 6SC® (alpha-cypermethrin) against Anopheles gambiae s.l. malaria vectors...

Malaria in developing countries [JIDC] — (English)
Review Article...

CD8+ T cells eliminate liver stage Plasmodium parasites without detectable bystander effect [IAI.01500-13] — (English)
We found that the non-cognate parasites developed normally in these mice demonstrating that bystander killing of parasites does not occur during the CD8+ T cell response to malaria parasites. Rather elimination of infected parasites is likely mediated by direct recognition of infected hepatocytes by antigen specific CD8+ T cells...

Potent malaria transmission blocking antibody responses elicited by Plasmodium falciparum Pfs25 expressed in E.coli after successful protein refolding [IAI.01438-13] — (English)
In the current study, codon harmonized recombinant Pfs25 (CHrPfs25) was expressed in E. coli, and purified protein after simple oxidative refolding steps retained reduction-sensitive conformational epitopes of transmission blocking monoclonal antibodies...

Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential [J Infect Dis. (2014) doi: 10.1093/infdis/jiu018] — (English)
Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages...

Developing inexpensive malaria vaccines from plants and algae [Applied Microbiology and Biotechnology] — (English)
Here, we review examples of these technologies and discuss the progress and potential of this research, as well as the obstacles ahead...

Transgenic approach to increase artemisinin content in Artemisia annua L. [Plant Cell Reports] — (English)
In this review, the progress on increasing artemisinin content in A. annua by transgenic approach and its future prospect are summarized and discussed...