27.01.2014

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Announcements / Press Releases

RBM Highlights Health & Development at Davos: World Economic Forum (WEF) Annual Meeting [RBM] — (English)
On the occasion of the World Economic Forum (WEF) Annual Meeting in Davos, the Roll Back Malaria Partnership (RBM) hosted a private gathering to highlight the intersection between health and the broader development agenda. Against the backdrop of preeminent global leaders, approximately 70 guests – including diplomats, private sector executives, NGO leaders and UN officials – discussed how best to engage the private sector and civil society in the Post-2015 development process and the role of health in the advancement of broader development targets. Remarks were provided by Ms. Amina Mohammed, United Nations Secretary-General’s Special Advisor for Post-2015 Development Planning, and Professor Jeffrey Sachs, United Nations Secretary-General’s Special Advisor for Millennium Development Goals (MDGs)...

22nd African Union Summit [African Union] — (English)
21-31 January 2014...

Team to study control of malaria-related parasite growth with $2.1-million NIH grant [USF Health] — (English)
Animal cells similar to those of humans contain a “control room,” called the centrosome, which regulates cell replication. Disrupt this core hub and you kill cell division. That is the simple idea behind a new five-year, $2.1-million National Institutes for Health grant recently awarded to the USF College of Public Health’s Department of Global Health and the Florida Center for Drug Development and Innovation...

The Roll Back Malaria Partnership Harmonization Working Group will be convening a series of workshops to support African countries to prepare applications for the Global Fund New Funding Model which will be fully launched at the end of March 2014 [RBM] — (English)
Application Closing Date: 31 January 2014...

President's Malaria Initiative (PMI): Senior Malaria Advisor, USAID/Burma [PMI] — (English)
Application Closing Date: 31 January 2014...

Coordinator to assist the Ministry of Health and Child Care [CHAI] — (English)
The Clinton Health Access Initiative (CHAI): is seeking a Coordinator to assist the Ministry of Health and Child Care in modeling and implementing optimal, cost-effective strategies for malaria control and elimination...

MMV: Travel Coordinator [MMV] — (English)
Application deadline: 7 February 2014 ...

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Articles requiring subscription or registration

Reduced erythrocyte deformability associated with hypoargininemia during Plasmodium falciparum malaria [Scientific Reports 4, Article number: 3767 doi:10.1038/srep03767] — (English)
Here, we explore the possible involvement of the L-arginine and nitric oxide (NO) pathway on RBC deformability in Pf-infected patients and parasite cultures...

Chemical biology: Knockout for malaria [Nature Chemistry 6, 93–94 (2014) doi:10.1038/nchem.1854] — (English)
Discovering and validating new targets is urgently required to tackle the rise in resistance to antimalarial drugs. Now, inhibition of the enzyme N-myristoyltransferase has been shown to prevent the formation of a critical subcellular organelle in the parasite that causes malaria, leading to death of the parasite...

Plasmodium genetic loci linked to host cytokine and chemokine responses [Genes and Immunity , (23 January 2014) | doi:10.1038/gene.2013.74] — (English)
These results provide important information for a better understanding of malaria pathogenesis and can be used to examine the role of these factors in human malaria infection...

Quantifying filariasis and malaria control activities in relation to lymphatic filariasis elimination: a multiple intervention score map (MISM) for Malawi [Tropical Medicine & International Health Volume 19, Issue 2, pages 224–235, February 2014] — (English)
Objective: sto quantify the geographical extent of filariasis and malaria control interventions impacting lymphatic filariasis (LF) in Malawi and to produce a multiple intervention score map (MISM) for prioritising surveillance and intervention strategies...

Prevalence of Malaria from Blood Smears Examination: A Seven-Year Retrospective Study from Metema Hospital, Northwest Ethiopia [Malaria Research and Treatment Volume 2013 (2013), Article ID 704730, 5 pages] — (English)
Seven-year malaria cases data had been collected from laboratory registration book. Results. A total of 55,833 patients were examined for malaria; of these, 9486 (17%) study subjects were positive for malaria....

Amodiaquine-Artesunate versus Artemether-Lumefantrine against Uncomplicated Malaria in Children Less Than 14 Years in Ngaoundere, North Cameroon: Efficacy, Safety, and Baseline Drug Resistant Mutations in pfcrt, pfmdr1, and pfdhfr Genes [Malaria Research and Treatment Volume 2013 (2013), Article ID 234683, 10 pages] — (English)
In Cameroon, both Artesunate-amodiaquine (AS/AQ) and artemether-lumefantrine (AL) are used as first-line treatment against uncomplicated malaria in line with the WHO recommendations. We compared the efficacy and safety of both therapeutic combinations and determined the prevalence of drug resistance conferring mutations in three parasite genes...

CD4+ T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria [The Journal of Immunology January 22, 2014 1200547] — (English)
These results suggest that a wide range of DBLα-tag–specific CD4+ T cell responses were induced in children with mild malaria and, in the case of CD4+IL-4+ T cell responses, were associated with protection from clinical episodes...

Reducing the Delay in Initiation of Treatment Improved Clinical Outcomes in Patients with Imported Malaria [Japanese Journal of Infectious Diseases Vol. 67 (2014) No. 1 p. 27-32] — (English)
Here, we retrospectively reviewed medical records of patients diagnosed with imported malaria in our hospital from 1991 to 2010...

Population pharmacokinetic assessment of the effect of food on piperaquine bioavailability in patients with uncomplicated malaria [AAC.02318-13] — (English)
The aim of this study was to use a population modeling approach to investigate the impact of concomitant intake of a small amount of food on piperaquine pharmacokinetics...

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes [Cellular Microbiology] — (English)
he adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past thirty years, fourteen endothelial receptors for iRBCs have been identified. Exposing ten additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties...

Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites [BMC Genomics 2014, 15:42 doi:10.1186/1471-2164-15-42] — (English)
The A. sinensis genome produced in this study, provides an important resource for analyzing the genetic basis of susceptibility and resistance of mosquitoes to Plasmodium parasites research which will ultimately facilitate the design of urgently needed interventions against this debilitating mosquito-borne disease....