3.02.2014

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Announcements / Press Releases

Farewell to Dr Robert Newman [Statement of the RBM Executive Director] — (English)
After four and half years at the helm of the WHO Global Malaria Programme o, Dr Robert Newman is moving to the GAVI Alliance o to become the organization’s new Managing Director for Policy and Performance. Dr Newman has been a long-standing member of the global malaria community and during his tenure he has built highly effective collaborations and a robust WHO policy-setting process on malaria...

Seven African Countries Lead the Continent in Malaria Control [RBM] — (English)
Annual awards – bestowed at the AU – highlight how Africa’s future is inextricably tied to progress in defeating malaria...

Online survey on the Guidelines for the treatment of malaria [WHO/GMP] — (English)
he WHO Global Malaria Programme is undertaking a rapid online survey on the current edition of the Guidelines for the treatment of malaria...

United Methodist gives $1.1 Million to fight malaria [UMC] — (English)
Imagine No Malaria will get a million-dollar-plus boost, thanks to a generous gift from a lifelong United Methodist who just wants to give back – the largest gift to date from an individual donor...

MMV: Medical Director [MMV] — (English)
Application Closing Date: 1 March 2014...

MMV: Travel Coordinator [MMV] — (English)
Application deadline: 7 February 2014 ...

WHO: GMP Director [WHO] — (English)
Application Closing Date: 10 March 2014...

WWARN: Communications Officer [WWARN] — (English)
Application Closing Date: 7 February 2014...

PATH: Senior Team Leader, Malaria Control and Evaluation Partnership in Africa [PATH] — (English)
Tracking Code: 5867 ...

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Articles requiring subscription or registration

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality [PNAS vol. 111 no. 4, E511–E520, doi: 10.1073/pnas.1316467111] — (English)
Here we investigated mouse genome-wide transcriptional responses to infections with two strains of Plasmodium yoelii (N67 and N67C) and discovered differences in innate response pathways corresponding to strain-specific disease phenotypes...

Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells [PNAS, vol. 111 no. 4, 1479–1484, doi: 10.1073/pnas.1323318111] — (English)
The small animal model reported here likely will facilitate the dissection of human immune responses to malaria parasite infection and the evaluation of therapeutics and vaccines...

Reemergence of Anopheles funestus as a Vector of Plasmodium falciparum in Western Kenya after Long-Term Implementation of Insecticide-Treated Bed Nets [Am J Trop Med Hyg 2014 13-0614] — (English)
These results are of serious concern for public health in the region, indicating that An. funestus may once again be contributing significantly to the transmission of malaria in this region despite the widespread use of ITNs/long-lasting insecticidal nets (LLINs)...

Synchrony in Malaria Infections: How Intensifying Within-Host Competition Can Be Adaptive [The University of Chicago Press for The American Society of Naturalists Article DOI: 10.1086/674357] — (English)
We use a delayed differential equation model to show that synchronized infections can be favored when (1) there is limited interference among parasites competing for red blood cells, (2) transmission success is an accelerating function of sexual parasite abundance, (3) the target of saturating immunity is short-lived, and (4) coinfections with asynchronous parasites are rare...

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children [Blood] — (English)
We conducted a case-control study of 996 children with severe Plasmodium falciparum malaria and 1220 community controls in Kilifi, Kenya and genotyped for Hp, HbS and α+thalassemia. HbAS and α+thalassemia homozygotes were protected from severe malaria (OR 0.12; 95% CI 0.07-0.18 and OR 0.69; 0.53-0.91 respectively)...

Formulation development and evaluation of the anti-malaria properties of sustained release artesunate-loaded solid lipid microparticles based on phytolipids [Informa Health] — (English)
Objectives: To formulate and evaluate artesunate-loaded solid lipid microparticles (SLMs) based on structured lipid matrices consisting of soybean oil and dika wax...

MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria [Infect. Immun. February 2014 vol. 82 no. 2 830-83] — (English)
In this study, we utilized a mouse model of placental malaria (PM) infection to determine the importance of the protein MyD88 in the host immune response to Plasmodium during pregnancy. Initially, we demonstrated that Plasmodium berghei NK65GFP adhered to placental tissue via chondroitin sulfate A and induced PM in mice with a C57BL/6 genetic background...

N-Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity [ChemMedChem Volume 9, Issue 2, pages 305–310, February 2014] — (English)
These findings bring new hope for the possible future “rise of a fallen angel” in antimalarial chemotherapy, with a potential resurgence of quinacrine-related compounds as dual-stage antimalarial leads...

Insecticide-treated mosquito nets in rural Burkina Faso: assessment of coverage and equity in the wake of a universal distribution campaign [Health Policy Plan. (2014) doi: 10.1093/heapol/czt108] — (English)
Our aim was to assess the coverage and equity effect of the universal distribution campaign of LLINs in Burkina Faso and to identify determinants of ITN ownership across households after the campaign...