24.02.2014

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Announcements / Press Releases

RBM Partners to strengthen in-country advocacy efforts [RBM] — (English)
More than 50 organizations meet at the Global Fund Secretariat in Geneva today to shape the future course of RBM's in-country advocacy. Changes in the development landscape and resource mobilization discussions place countries and regional institutions centre-stage. Partners will address one persistent challenge in mobilizing domestic resources for malaria at the country level, which is a lack of national-level advocates who can consistently work on the ground in endemic countries to build networks and reach out to decision makers...

National Malaria Control Program Managers Meeting [RBM] — (English)
The four RBM Subregional Networks and Malaria Control Managers in the African Region and Yemen will all meet together for the first time, to discuss their works plans for this year and future collaboration with RBM. The meeting aims to build on current practices to develop a stronger collaboration with RBM towards achieving better health outcomes in 2015 and beyond...

Ninth Vector Control Working Group meeting [RBM] — (English)
192 experts from 44 countries, including net manufacturers and distributors, researchers, academics, behaviour change communication specialists, and representatives from donor and malaria-endemic countries, the private sector, philanthropic foundations, non-governmental organizations, and multilateral agencies, met to discuss recent developments in the vector control landscape, and to review the draft 2014 VCWG workplan. Topics of discussion included insecticide resistance, continuous LLIN distribution systems, durability of LLINs in the field, capacity building for indoor residual spraying, larval source management , optimizing evidence for vector control interventions, entomological monitoring, and malaria and housing...

Alliance for Malaria Prevention meeting [RBM] — (English)
Advocates, net manufacturers and distributors, donors, behaviour change communications specialists, experts from malaria endemic countries, and representatives from research institutions, non-governmental organizations, and multilateral agencies met in Geneva to take stock of challenges and opportunities to accelerate the delivery and use of long lasting insecticidal nets, to maximize progress towards the RBM malaria goals by 2015...

Protein essential to the spread of malaria uncovered [Wellcome Trust Sanger Institute Press release] — (English)
Master switch discovered that triggers the development of sexual forms of the malaria parasite...

Malaria maps reveal that 184 million Africans still live in extremely high-risk areas despite decade of control efforts [WellcomeTrust Press release] — (English)
Forty African countries showed reductions in malaria transmission between 2000-2010, but despite this progress, more than half (57 per cent) of the population in countries endemic for malaria continue to live in areas of moderate to intense transmission, with infection rates over 10 per cent. The findings are based on a series of prevalence maps for malaria published this week in the Lancet...

World Bank to Help Togo Protect Vulnerable Women and Children from Malaria and Malnutrition [The WB Group Press release] — (English)
The World Bank’s Board of Executive Directors has approved support to Togo that will help the country offer lifesaving health and nutrition services to over 1.3 million people, nearly 60 percent of whom are women and girl children under the age of five...

Malaria Consortium reflects on a decade in disease control [Interview of Dr Sylvia Meek to The Guardian] — (English)
To mark Malaria Consortium's 10th anniversary, founder and technical director Dr Sylvia Meek reflects on a decade of progress in disease control...

Malaria Policy Advisory Committee to convene on 12-14 March [WHO/GMP] — (English)
Next month, the Malaria Policy Advisory Committee will review evidence and draft guidance documents on the prioritization of vector control interventions in resource-constrained settings, on combining indoor residual spraying with long-lasting insecticidal nets, and on diagnostic testing in low transmission settings. The Committee will also discuss the draft Global Technical Strategy for Malaria Control and Elimination 2016-2025 and receive updates from experts on the RTS,S vaccine candidate, the process for updating the malaria treatment guidelines and many other topics...

RBM Partnership: Call for consultants to support countries in the development of Global Fund NFM Concept Notes and subsequent implementation [RBM] — (English)
Application Closing Date: 28 February 2014. Read Call for consultants and Background information on the RBM web...

WHO/GMP: Director [MMV] — (English)
Application deadline: 10 March 2014 ...

MMV: Project Coordinator, Translational Medicine [MMV] — (English)
Application deadline: 14 March 2014 ...

MMV: Associate Director, Drug Discovery – Medicinal Chemistry [MMV] — (English)
Application deadline: 14 March 2014 ...

MMV: Associate Director, Pharmacometrics [MMV] — (English)
Application deadline: 6 March 2014 ...

MMV: Medical Director [MMV] — (English)
Application deadline: 1 March 2014 ...

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Articles requiring subscription or registration

The changing risk of Plasmodium falciparum malaria infection in Africa: 2000—10: a spatial and temporal analysis of transmission intensity [The Lancet, Early Online Publication, 20 February 2014 doi:10.1016/S0140-6736(13)62566-0] — (English)
We assembled a geocoded and community Plasmodium falciparum parasite rate standardised to the age group 2—10 years (PfPR2—10) database from across 49 endemic countries and territories in Africa from surveys undertaken since 1980. The data were used within a Bayesian space—time geostatistical framework to predict PfPR2—10 in 2000 and 2010 at a 1 × 1 km spatial resolution. Population distribution maps at the same spatial resolution were used to compute populations at risk by endemicity class and estimate population-adjusted PfPR2—10 (PAPfPR2—10) for each of the 44 countries for which predictions were possible for each year...

African origin of the malaria parasite Plasmodium vivax [Nature Communications 5, Article number: 3346 doi:10.1038/ncomms4346] — (English)
Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax...

Odorant receptor-mediated sperm activation in disease vector mosquitoes [PNAS] — (English)
In this study, we have identified a subset of odorant receptors showing transcript expression in the testes of the malaria mosquito, Anopheles gambiae...

Infection of Laboratory-Colonized Anopheles darlingi Mosquitoes by Plasmodium vivax [Am J Trop Med Hyg 2014 13-0708] — (English)
Here, we report the establishment of an An. darlingi colony derived from wild-caught mosquitoes obtained in the northeastern Peruvian Amazon region of Iquitos in the Loreto Department...

Expression of the essential kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs [AAC.02261-13] — (English)
We show that expression of PfCDPK1 in the TgCDPK3 mutant strain rescues the egress defect...

Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model [Parasitology Research February 2014] — (English)
For the benefit of those who use traditional medicine to treat malaria, there is an urgent need to study the efficacy and toxicity of herbal remedies. Hintonia latiflora stem bark infusions are use in Mexican traditional medicine to treat malaria, diabetes, and gastrointestinal diseases. Its efficacy in the treatment of complicated malaria and its ability to generate DNA damage to the host is not fully evaluated...

The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission [Parasitology, DOI: http://dx.doi.org/10.1017/S0031182013002278 ] — (English)
Here we examined whether the recent dramatic decline in malaria transmission in Sri Lanka led to a major bottleneck in the local Plasmodium vivax population, with a substantial decrease in the effective population size...

The acute transcriptomic and proteomic response of HC-04 hepatoma cells to Hepatocyte Growth Factor and its implications for Plasmodium falciparum sporozoite invasion [10.1074/mcp.M113.035584 mcp.M113.035584] — (English)
We hypothesized that HCCs are in various intermediate stages of the epithelial-mesenchymal transition (EMT) and HC-04s retain epithelial characteristics that permit infection. We developed a facile analytical approach to test this hypothesis viz. the HC-04 response to hepatocyte growth factor (HGF)...

Malaria and HIV interactions anno 2014 [CMI DOI: 10.1111/1469-0691.12597] — (English)
Two decades of research learned that HIV related immune suppression is correlated with increased malaria infection, burden and treatment failure and with complicated malaria irrespective of the immune status...

Uncovering the hideout of malaria sexual parasites [Blood February 13, 2014 vol. 123 no. 7 954-955] — (English)
In this issue of Blood, Aguilar and colleagues1 present the result of a timely and much-needed investigation aimed to unveil the hidden sites of maturation of Plasmodium falciparum transmission stages in human malaria infections...

The role of antioxidants treatment on the pathogenesis of malarial infections: a review [Parasitology Research March 2014, Volume 113, Issue 3, pp 801-809] — (English)
This article critically reviews most of the studies conducted on the potential role of antioxidant therapy in malarial infections...