03.03.2014

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Announcements / Press Releases

Roll Back Malaria (RBM) Partnership is a new Partner of the Fight the Fakes Campaign! [RBM] — (English)
Fake medicines are a threat to public health and put patients at risk of drug resistance, prolonged illness, disability and even death. Their negative impacts can undermine entire public health initiatives and patient trust in healthcare systems and providers. A comprehensive strategy to combat fake medicines requires multi-stakeholder collaboration at local and global levels. Please visit www.fightthefakes.org and follow us on Twitter (@FightTheFakes) to learn more about our involvement. ...

Twenty-second MERG meeting [RBM] — (English)
More info on MERG...

Global Fund News Flash: Issue 38 [The Global Fund] — (English)
What is Country Dialogue?...

Moving towards malaria elimination [Malaria Consortium Learning Paper] — (English)
Developing innovative tools for malaria surveillance in Cambodia...

Communications Consultant (Ref:2014/01) [WHO/GMP] — (English)
The Geneva-based RAcE project team is seeking the services of a communication consultant to develop a communications and information dissemination strategy, provide advice on strategic and programmatic communications issues, and increase the visibility of the project in implementation countries, regionally and globally...

WHO/GMP: Director [MMV] — (English)
Application deadline: 10 March 2014 ...

MMV: Project Coordinator, Translational Medicine [MMV] — (English)
Application deadline: 14 March 2014 ...

MMV: Associate Director, Drug Discovery – Medicinal Chemistry [MMV] — (English)
Application deadline: 14 March 2014 ...

MMV: Associate Director, Pharmacometrics [MMV] — (English)
Application deadline: 6 March 2014 ...

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Articles requiring subscription or registration

A transcriptional switch underlies commitment to sexual development in malaria parasites [Nature (2014) doi:10.1038/nature12920] — (English)
Here we show that expression levels of the DNA-binding protein PfAP2-G correlate strongly with levels of gametocyte formation. Using independent forward and reverse genetics approaches, we demonstrate that PfAP2-G function is essential for parasite sexual differentiation...

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium [Nature (2014) doi:10.1038/nature12970] — (English)
Here we show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essential for the commitment of asexually replicating forms to sexual development in Plasmodium berghei, a malaria parasite of rodents. PbAP2-G was identified from mutations in its encoding gene, PBANKA_143750, which account for the loss of sexual development frequently observed in parasites transmitted artificially by blood passage...

Modeling the seasonality of Anopheles gambiae s.s. biting rates in a South Benin sanitary zone [Trans R Soc Trop Med Hyg (2014) doi: 10.1093/trstmh/tru027] — (English)
We have classified village groups according to the biting rate profiles of both Anopheles coluzzii and An. gambiae, the major malaria vectors in these villages...

Malaria control in Africa: progress but still much to do [he Lancet, Early Online Publication, 20 February 2014 doi:10.1016/S0140-6736(14)60044-1] — (English)
During the past two decades, the international community has invested heavily in malaria control, especially in sub-Saharan Africa, with support increasing from around US$100 million in 2000 to nearly $2 billion in 2013...

The changing risk of Plasmodium falciparum malaria infection in Africa: 2000—10: a spatial and temporal analysis of transmission intensity [The Lancet, Early Online Publication, 20 February 2014 doi:10.1016/S0140-6736(13)62566-0] — (English)
Substantial reductions in malaria transmission have been achieved in endemic countries in Africa over the period 2000—10. However, 57% of the population in 2010 continued to live in areas where transmission remains moderate to intense and global support to sustain and accelerate the reduction of transmission must remain a priority...

Cerebral malaria in children: using the retina to study the brain [Brain (2014) doi: 10.1093/brain/awu001] — (English)
e aimed to determine the extent to which paediatric malarial retinopathy reflects cerebrovascular damage by reviewing the literature to compare retinal and cerebral manifestations of retinopathy-positive paediatric cerebral malaria...

High prevalence and genetic diversity of Plasmodium malariae and no evidence of Plasmodium knowlesi in Bangladesh [Parasitology Research February 2014] — (English)
We conclude that the role of P. malariae is highly underestimated in rural Bangladesh with major implications for malaria control and elimination strategies...

Effect of Iron/Folic Acid Supplementation on the Outcome of Malaria Episodes Treated with Sulfadoxine-Pyrimethamine [Malaria Research and Treatment Volume 2014 (2014), Article ID 625905, 5 pages http://dx.doi.org/10.1155/2014/625905] — (English)
In a double masked, placebo-controlled trial among preschool children in Pemba Island (Tanzania), iron and folic acid supplementation (Fe/FA) showed an increased risk of hospitalizations and death. In the present paper, we evaluated if folic acid supplementation reduced the efficacy of malaria treatment and thereby contributed to observed adverse effects...

Evaluation of Loop-Mediated Isothermal Amplification (LAMP) Assay for Rapid Diagnosis of Malaria Infections in an Endemic Setting in Thailand [JCM.03313-13 ] — (English)
Loop-mediated isothermal amplification (LAMP) method, developed by our group for diagnosis of four human malaria parasites was evaluated on a large scale in a malaria endemic setting in a remote clinic in Thailand...

Beyond malaria--causes of fever in outpatient Tanzanian children [N Engl J Med. 2014 Feb 27;370(9):809-17. doi: 10.1056/NEJMoa1214482] — (English)
These results provide a description of the numerous causes of fever in African children in two representative settings. Evidence of a viral process was found more commonly than evidence of a bacterial or parasitic process...

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites [Cellular Microbiology] — (English)
Here, we have placed the Pfama1 gene under conditional control using dimerizable Cre recombinase (DiCre) in P. falciparum...

B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens in Ghanaian women naturally exposed to malaria parasites [IAI.01514-13 ] — (English)
We measured PfEMP1-specific antibody levels by ELISA and memory B-cell frequencies by ELISPOT assays in a cohort of P. falciparum-exposed non-pregnant Ghanaian women...

Identification of Cryptosporidium parvum active chemical series by repurposing the Open Access Malaria Box [AAC.02641-13 ] — (English)
We identified 3 novel chemical series derived from the quinolin-8-ol, allopurinol-based, and 2,4-diamino-quinazoline chemical scaffolds that exhibited sub-micromolar potency against C. parvum...