24.03.2014

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Announcements / Press Releases

United Against Malaria Awarded Global Campaign of the Year by PRWeek [UAM] — (English)
Boutique agency KYNE and the Roll Back Malaria Partnership (RBM) announced that United Against Malaria (UAM) was named Global Campaign of the Year at the 2014 PRWeek Awards ceremony held in New York City last night, the premier accolades of the communications industry. The designation honors UAM's seamless integration into the 2013 Orange™ Africa Cup of Nations (AFCON) soccer tournament, reaching an estimated 1 billion people with life-saving messages about prevention and treatment of malaria...

Indonesia: In one girl’s recovery, an island’s triumph over malaria [UNICEF] — (English)
An island once suffering from a record number of malaria cases has managed to eradicate all indigenous cases of the disease, which is a leading cause of death among children under age 5...

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Articles requiring subscription or registration

The interaction between malaria and human immunodeficiency virus infection in severely anaemic Malawian children: a prospective longitudinal study [Tropical Medicine & International Health] — (English)
Severely anaemic HIV-infected children showed no increased susceptibility to asymptomatic or symptomatic malaria during or following their anaemic episode, although all experienced lower parasite prevalence during follow-up. This contrasts with data in adults and may relate to the malaria immunity of young children which is insufficiently developed to be impaired by HIV. The negative correlation between viral load and malaria parasitaemia remains unexplained...

Comprehensive Sterilization of Malaria Vectors Using Pyriproxyfen: A Step Closer to Malaria Elimination [Am J Trop Med Hyg 2014 13-0550] — (English)
This study investigated a novel technology for population control that sterilizes mosquitoes using pyriproxyfen, a juvenile hormone analogue...

Using Mitochondrial Genome Sequences to Track the Origin of Imported Plasmodium vivax Infections Diagnosed in the United States [Am J Trop Med Hyg 2014 13-0588] — (English)
We hypothesized that mitochondrial haplotypes could provide region-specific molecular barcodes for tracing the origin of imported Plasmodium vivax infections...

Spleen volume and clinical disease manifestations of severe Plasmodium falciparum malaria in African children [Trans R Soc Trop Med Hyg (2014) doi: 10.1093/trstmh/tru040] — (English)
SV is lower in CM compared to SMA. Severe malaria with no increase in SV z-score may be associated with mortality...

Malaria vaccine: A step toward elimination [Hum Vaccin Immunother. 2014 Mar 18;10(6] — (English)
Malaria Vaccine Technology Road Map 2013 has envisaged the world aiming for a licensed vaccine by 2030 that would reduce malaria cases by 75% and be capable of eliminating malaria. It will not only fill the gaps of today’s interventions but also be a cost-effective method of decreasing morbidity and mortality from malaria...

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity [Mol Biol Evol (2014) doi: 10.1093/molbev/msu106] — (English)
Genome-wide analysis of sequence variation was undertaken on a sample of 100 P. falciparum clinical isolates from a highly endemic region of the Republic of Guinea where transmission occurs for most of each year, and compared with data from 52 clinical isolates from a previously sampled population from The Gambia where there is relatively limited seasonal malaria transmission...

Increased Survival in B-Cell-Deficient Mice during Experimental Cerebral Malaria Suggests a Role for Circulating Immune Complexes [doi: 10.1128/mBio.00949-14] — (English)
Our findings highlight the importance of complement and immune complexes in experimental cerebral malaria...

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) [J Med Chem.] — (English)
These data further validate NMT as an exciting drug target in malaria and support 34c as an attractive tool for further optimization...

A retrospective study on imported Malaria in Jordan. 1. Malaria among Jordanian UN peacekeeping forces [Bulletin de la Société de pathologie exotique March 2014] — (English)
There was an evident reduction of malaria attack rate and relapse rate between the two groups Timor (without post-exposure prophylaxis) and Timor 2 and 3 (given post exposure prophylaxis)...

The path of malaria vaccine development: challenges and perspectives [Journal of Internal Medicine] — (English)
In this review we will discuss recent strategies to develop efficient malaria vaccines...

Combined efforts in immunology and vaccinology will lead to effective vaccines against HIV, tuberculosis and malaria [Journal of Internal Medicine] — (English)
During the course entitled ‘Novel vaccination strategies against the three major killers’, the latest advances in the field of vaccines against HIV, TB and malaria as well as vaccine development in general were presented. Expert scientists working on different aspects of vaccination against these three pathogens and related diseases gathered for this course...

Price subsidies increase the use of private sector ACTs: evidence from a systematic review [Health Policy Plan. (2014) doi: 10.1093/heapol/czu013] — (English)
This review provides an initial foundation for policymakers to make evidence-based decisions regarding ACT price reductions to increase use of potentially life-saving drugs...

Malaria Immunity in Man and Mosquito: Insights into Unsolved Mysteries of a Deadly Infectious Disease [Annual Review of Immunology Vol. 32: 157-187 (Volume publication date March 2014) DOI: 10.1146/annurev-immunol-032713-120220] — (English)
Here we review what is known about the mechanisms at play in immune resistance to malaria in both the human and mosquito hosts at each step in the parasite's complex life cycle with a view toward developing the tools that will contribute to the prevention of disease and death and, ultimately, to the goal of malaria eradication. In so doing, we hope to inspire immunologists to participate in defeating this devastating disease...