21.04.2014

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Announcements / Press Releases

World Malaria Day 2014 [RBM] — (English)
The past decade has shown what is possible when we work together. Since 2000, we have cut child deaths from malaria in half, and the malaria map continues to shrink. But emerging threats of drug and insecticide resistance heightens urgency to be even more resilient and adaptive...

The first joint RBM and STOPTB civil society workshop [RBM] — (English)
More than 30 Civil society and CCM representatives from Botswana, Liberia, Zimbabwe, Swaziland, Sudan, Namibia, Rwanda, Gambia, Kenya, Somalia , and Nigeria examined human rights, gender and community systems strengthening in the first joint RBM and STOPTB civil society workshop in Harare. They identified barriers to equitable access to malaria and TB services and reviewed the challenges of their meaningful participation in Country Coordinating Mechanisms CCMs and the New Funding Model processes...

Southern Africa starts a race against malaria [RBM] — (English)
South Africa is once again gearing up for the "Racing Against Malaria" initiative (RAM 2), a car rally that passes through eight countries in the South Africa Development Community (SADC) to promote malaria control and elimination efforts in the region. Between April 14 and April 25 (World Malaria Day), the race from Lilongwe to Odnjiva (Angola) will bring together all malaria control programme teams from the region, as well as their key partners and stakeholders. At various stops in cross-border districts, partners will stress the importance of testing for, treating and tracking malaria cases in cross-border initiatives, aimed at malaria elimination...

MPAC Survey on stakeholder perceptions [WHO/GMP] — (English)
The Global Malaria Programme and the Malaria Policy Advisory Committee (MPAC) are seeking input from Member States and external malaria stakeholders on their perceptions of the MPAC’s work. The Survey on stakeholder perceptions will be open until 9 May – it is available on the GMP website...

Introducing rapid diagnostic tests for malaria in rural Africa can reduce wastage of antimalarial drugs but may not improve patient health outcomes [LSTM] — (English)
Researchers from the Cochrane Infectious Diseases Group conducted a review of the effects of introducing rapid diagnostic tests (RDTs) for diagnosing malaria in primary healthcare settings in Africa where laboratory services are unavailable. The review included seven randomized controlled trials, enrolling 17,505 people with fever, and found that using RDTs reduced the prescription of antimalarial drugs by up to three-quarters, but didn’t change the number of people still unwell a week later....

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Articles requiring subscription or registration

Effect of Warming Temperatures on Malaria Incidence [JAMA. 2014;311(15):1489. doi:10.1001/jama.2014.4010] — (English)
Higher altitudes in the tropics typically experience seasonal periods of cooler temperatures, which can interrupt the life cycle of the malaria parasite, helping to lower the intensity of disease transmission. In recent years, questions have arisen as to whether climate warming trends are increasing the incidence of malaria in these densely populated highland regions...

Global malaria efforts: Progress made, but challenges loom ahead [Trans R Soc Trop Med Hyg (2014) 108 (5): 247-248] — (English)
‘Invest in the future. Defeat malaria,’ the theme of World Malaria Day 2013,1 still struck a chord with the outgoing WHO Global Malaria Program Director, Dr Robert Newman, during the release of the latest World Malaria Report on 11 December 20132 in Washington D.C. Dr Newman stated that ‘the greatest threat to continued success in malaria efforts is financial,’ as the community had less than half of the US$5.1 billion needed annually to ensure universal access to life-saving malaria interventions, including long-lasting insecticidal nets (LLINs), indoor residual spraying of households with insecticide (IRS), intermittent preventive chemotherapy for pregnant women (IPTp), rapid diagnostic tests (RDTs) and arteminisin combination therapies (ACTs)...

A Case of Quadruple Malaria Infection Imported from Mozambique to Japan [Am J Trop Med Hyg 2014 13-0477] — (English)
The present case is a rare instance of a mixed infection with four species of Plasmodium. Nonimmune persons in malaria-endemic areas may have a risk of mixed infection. All four species must be identified by using sensitive and specific tests, such as a nested polymerase chain reaction, in addition to conventional morphologic identification...

A Cross-Sectional Survey of Plasmodium falciparum pfcrt Mutant Haplotypes in the Democratic Republic of Congo [Am J Trop Med Hyg 2014 13-0378] — (English)
Across the DRC, we genotyped 166 parasites in Plasmodium falciparum chloroquine resistance transporter (pfcrt) using polymerase chain reaction (PCR) and sequencing. Of these parasites, 73 (44%) parasites were pure wild-type CVMNK, 55 (31%) parasites were chloroquine-resistant CVIET, 35 (21.1%) parasites were mixed CVMNK and CVIET, and 3 parasites were other genotypes...

Compliance with Antimalarial Chemoprophylaxis Recommendations for Wounded United States Military Personnel Admitted to a Military Treatment Facility [Am J Trop Med Hyg 2014 13-0646] — (English)
We assessed antimalarial primary chemoprophylaxis and presumptive antirelapse therapy (primaquine) compliance among wounded United States military personnel after medical evacuation from Afghanistan (June 2009–August 2011) to Landstuhl Regional Medical Center in Landstuhl, Germany, and then to three U.S. military hospitals...

Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens [J Infect Dis. (2014) doi: 10.1093/infdis/jiu225] — (English)
Antibodies to P. falciparum antigens in malaria endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria>...

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules [AAC.02721-13] — (English)
Our data identify HDAC inhibitors as being among a limited number of compounds that target both asexual and sexual stage malaria parasites, making them a potential new starting point for gametocytocidal drug leads and valuable tools for dissecting gametocyte biology...

Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso [AAC.02406-14] — (English)
Seasonal malaria chemoprevention (SMC), with regular use of amodiaquine/sulfadoxine-pyrimethamine (AQ/SP) during the transmission season, is now a standard malaria control measure in the Sahel sub-region of Africa...

Plasmodium ovale malaria in Brazil: report of an imported case with a prolonged incubation period [JIDC] — (English)
We report the first case of imported Plasmodium ovale in Brazil, confirmed using both conventional microscopy and PCR-based protocols. The patient was a 36-year-old Brazilian male who had been working as a miner in Cabinda Province, Angola. Based on his travel history, the parasite was dormant for at least two years. The relatively long period of incubation of P. ovale may obscure the link between exposure and disease. The recent increase in the number of people travelling to regions where P. ovale is endemic, suggests that a PCR-based protocol should be included as a complementary tool for malaria reference laboratories...

Immune responses during gestational malaria: a review of the current knowledge and future trend of research [JIDC] — (English)
This review summarized the main aspects involved in the acqui

sition of specific antimalarial immune responses during pregnancy with emphasis in research carried out in America and Asia, in order to offer a framework of interpretation for studies on pregnant women with malaria which are recently being produced in these regions...