23.06.2014

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Announcements / Press Releases

OIC member states account for almost half of all malaria cases worldwide [RBM] — (English)
A new study by Roll Back Malaria (RBM) Partnership on Sunday revealed that 238 million malaria cases, nearly half of malaria cases worldwide, are found in member states belonging to the Organisation of the Islamic Cooperation (OIC)...

UNDP/RBM video calls for support to end one of the deadliest diseases on earth [RBM / UNDP] — (English)
Football legend Didier Drogba urges taking action against malaria...

Senior Computational Statistician: Spatial Model [Malaria Atlas Project] — (English)
The Department of Zoology at the University of Oxford is looking for an experienced statistical modeller with skills in conceiving, implementing, and testing bespoke spatial statistical models on a 2-year fixed-term contract...
Application deadline: 16.07.2014...


Malaria Atlas Project: SEEG Data Archive Manager [Malaria Atlas Project] — (English)
The Data Archive Manager will be responsible for the management of the group’s spatiotemporal data archives, supporting this area of highly technical and interdisciplinary science...
Application deadline: 16.07.2014...


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Articles requiring subscription or registration

Rapid diagnostic tests for malaria [BMJ 2014; 348 doi: http://dx.doi.org/10.1136/bmj.g384] — (English)
A useful tool for managing fever in countries with endemic disease, but not necessarily a substitute for good microscopy...

Rapid diagnostic tests to improve treatment of malaria and other febrile illnesses: patient randomised effectiveness trial in primary care clinics in Afghanistan [BMJ 2014; 348 doi: http://dx.doi.org/10.1136/bmj.g3730] — (English)
In South and central Asian regions of low to moderate malaria transmission where clinics lack capacity for diagnosis with rapid diagnostic tests or microscopy, the introduction of the tests should be considered to improve clinical care, reduce the overuse of antimalarials, and improve disease surveillance...

Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria [Am J Trop Med Hyg 2014 14-0116] — (English)
An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in the pathogenesis of cerebral malaria is warranted...

Vaccine development and developing countries [The Lancet, Volume 383, Issue 9935, Page 2099, 21 June 2014] — (English)
There is no shortage of disease targets in need of vaccines. Although development of vaccines against HIV continues to pose serious challenges for both basic and clinical researchers, vaccines against malaria and dengue (both infectious diseases that cause major burdens of morbidity and mortality concentrated in developing countries) are in advanced stages of clinical assessment...

Translating the immunogenicity of prime-boost immunisation with ChAd63 and MVA ME-TRAP from malaria naïve to malaria-endemic populations [Nature Communications 5, Article number: 4098 doi:10.1038/ncomms5098] — (English)
Malaria and toxoplasmosis are infectious diseases caused by the apicomplexan parasites Plasmodium and Toxoplasma gondii, respectively. These parasites have developed an invasion mechanism involving the formation of a moving junction (MJ) that anchors the parasite to the host cell and forms a ring through which the parasite penetrates... Our study highlights a considerable complexity and molecular plasticity in the architecture of the MJ...

Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin [Journal of Structural and Functional Genomics June 2014, Volume 15, Issue 2, pp 63-71] — (English)
Here, we present crystal structure of ternary PfKRS-lysine-cladosporin (PfKRS-K-C) complex that reveals cladosporin’s remarkable ability to mimic the natural substrate adenosine and thereby colonize PfKRS active site...

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates [J Infect Dis. (2014) doi: 10.1093/infdis/jiu349] — (English)
The sequence variations observed at drug-resistance loci reflect differences in each country's historical use of antimalarial drugs, and may be useful in formulating local malaria treatment guidelines...

Randomized Trial of Artesunate-Amodiaquine, Atovaquone-Proguanil, and Artesunate-Atovaquone-Proguanil for the Treatment of Uncomplicated Falciparum Malaria in Children [J Infect Dis. 2014] — (English)
Atovaquone-proguanil was characterized by a slow blood schizontocidal action and resulted in early treatment failure in a few patients. Artesunate-atovaquone-proguanil was a highly effective alternative treatment...

Identification of inhibitors of Plasmodium falciparum RuvB1 helicase using biochemical assays [Protoplasma June 2014] — (English)
In the present study, the screening of various compounds was done and the results suggest that PfRuvB1 ATPase activity is inhibited considerably by the novobiocin and partially by cisplatin and ciprofloxacin...