30.06.2014

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Announcements / Press Releases

Community and Country level Consultations on GMAP2 are now underway [RBM] — (English)
A series of country consultations for GMAP2 have now started. These consultations start with engagement visits to affected communities, followed by a national consultative meeting with a wide spectrum of stakeholders from community to central level, and from different constituencies and sectors...

Vaccine Made from Complex of Two Malaria Proteins Protects Mice From Lethal Infection [NIH HHS News Release Logo National Institute of Allergy and Infectious Diseases (NIAID)] — (English)
An experimental vaccine designed to spur production of antibodies against a key malaria parasite protein, AMA1, was developed more than decade ago by scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. It showed promise in test-tube and animal experiments and in early-stage clinical trials, but returned disappointing results in recent human trials conducted in malaria-endemic countries...

New Framework on Malaria Drugs to Save $100 Million [The Global Fund] — (English)
In a major initiative that fundamentally changes how anti-malaria drugs are procured, the Global Fund is entering into new framework agreements with suppliers of artemisinin-based combination therapy (ACT) that are aimed at improving delivery and having a bigger impact, both in value for money and in lives saved...

Financement d’études épidémiologiques [l’Initiative 5%] — (English)
En 2014 et dans le but de faciliter l’élaboration de Notes Conceptuelles, le Comité de Pilotage de l’Initiative 5% a décidé d’ouvrir le Canal 1 au financement d’ÉTUDES ÉPIDEMIOLOGIQUES...

New Fight the Fakes testimonial [Fight the Fakes] — (English)
While the illicit trade of fake medicines has reached a global scale and impact, the availability and sale of fake drugs tends to be concentrated in specific regional contexts. In the Mekong Region, where there is a high mobility of labour and goods across borders, regional solutions are needed to protect the lives of innocent patients...

Senior Computational Statistician: Spatial Model [Malaria Atlas Project] — (English)
The Department of Zoology at the University of Oxford is looking for an experienced statistical modeller with skills in conceiving, implementing, and testing bespoke spatial statistical models on a 2-year fixed-term contract...
Application deadline: 16.07.2014...


Malaria Atlas Project: SEEG Data Archive Manager [Malaria Atlas Project] — (English)
The Data Archive Manager will be responsible for the management of the group’s spatiotemporal data archives, supporting this area of highly technical and interdisciplinary science...
Application deadline: 16.07.2014...


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Articles requiring subscription or registration

Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria [PNAS] — (English)
Our data suggest that a multiallele AMA1 (to overcome polymorphisms) in complex with RON2L should be effective in protecting against all Plasmodium falciparum parasites...

Community Health Workers and Stand-Alone or Integrated Case Management of Malaria: A Systematic Literature Review [Am J Trop Med Hyg 2014 14-0094] — (English)
A systematic literature review was conducted to assess the effectiveness of strategies to improve community case management (CCM) of malaria...

Validation of a chloroquine-induced cell death mechanism for clinical use against malaria [Cell Death and Disease (2014) 5, e1305; doi:10.1038/cddis.2014.265] — (English)
An alternative antimalarial pathway of an ‘outdated’ drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to efflux this drug from the digestive vacuole (DV)...

Scaling up integrated prevention campaigns for global health: costs and cost-effectiveness in 70 countries [BMJ OPen] — (English)
IPC appears cost-effective in many settings, and has the potential to substantially reduce the burden of disease in resource-poor countries. This study increases confidence that IPC can be an important new approach for enhancing global health...

Effectiveness of intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy on placental malaria, maternal anaemia and birthweight in areas with high and low malaria transmission intensity in Tanzania [Tropical Medicine & International Health] — (English)
To assess the effectiveness of IPTp in two areas with different malaria transmission intensitiess...

The origins of malaria: there are more things in heaven and earth [Parasitology] — (English)
This review summarizes some of those recent discoveries and discusses their implication for our current understanding of the origin and evolution of the Plasmodium genus...

Modelling heterogeneity in malaria transmission using large sparse spatio-temporal entomological data [Global Health Action] — (English)
This work demonstrates a rigorous approach for analysing large and highly variable entomological data for the study of malaria transmission heterogeneity, measured by EIR, within the Rufiji Demographic Surveillance System (DSS), MTIMBA project site in Tanzania...

Vitamin D Inhibits the Occurrence of Experimental Cerebral Malaria in Mice by Suppressing the Host Inflammatory Response [The Journal of Immunology June 25, 2014 1400089] — (English)
We observed that oral administration of VD both before and after PbA infection completely protected mice from ECM...

Using Rasch Modeling to Re-Evaluate Rapid Malaria Diagnosis Test Analyses [Int. J. Environ. Res. Public Health 2014, 11(7), 6681-6691; doi:10.3390/ijerph110706681] — (English)
The objective of this study was to demonstrate the use of the Rasch model by assessing the appropriateness of the demographic, social-economic and geographic factors in providing a total score in malaria RDT in accordance with the model’s expectations...

Memory B-cell and antibody responses induced by Plasmodium falciparum sporozoite immunization [J Infect Dis. (2014) doi: 10.1093/infdis/jiu354] — (English)
Humoral responses to the malarial antigens CircumSporozoite Protein, Liver-Stage Antigen-1, Apical Membrane Antigen-1 and Merozoite Surface Protein-1 do not to predict protection from challenge infection, but can be used as sensitive marker of recent parasite exposure...

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda [J. Antimicrob. Chemother. (2014) doi: 10.1093/jac/dku228] — (English)
The aim of this study was to investigate the pharmacokinetic properties of oral quinine in pregnant women with uncomplicated malaria in Uganda using a population approach...

Immunogenicity of a synthetic vaccine based on the Plasmodium vivax Duffy Binding Protein Region II [CVI.00205-14] — (English)
In this study, we further characterized the immunogenicity of DEKnull, finding immunization with rDEKnull produced an immune response comparable to native recombinant DBP alleles. Further investigation of DEKnull is necessary to enhance its immunogenicity and broaden its specificity...

Lopinavir/ritonavir versus Efavirenz-based Antiretroviral Treatment for the Prevention of Malaria among HIV-infected Pregnant Women [J Infect Dis. (2014) doi: 10.1093/infdis/jiu346] — (English)
We sought to evaluate whether lopinavir/ritonavir-based antiretroviral therapy (ART) reduced the risk of placental malaria...

Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection [IAI.01922-14] — (English)
Our data further strengthen the idea that IL-10 and IP-10 could be useful diagnostic markers of P. falciparum infection during pregnancys...

Artesunate versus Chloroquine Infection–Treatment–Vaccination Defines Stage-Specific Immune Responses Associated with Prolonged Sterile Protection against Both Pre-erythrocytic and Erythrocytic Plasmodium yoelii Infection [The Journal of Immunology June 23, 2014 1400296] — (English)
Our data show that ITV strategies that lead to subtle differences in the persistence of parasites in the blood enable the characterization of the resulting immune responses, which will contribute to future research in vaccine design and malaria interventions...

Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of Kenya after prolonged absence of malaria exposure [IAI.01924-14] — (English)
The study findings provide a strong rationale for future studies of antigen-specific IFN-γ, TNF-α and IL-10 responses as biomarkers of increased population-level susceptibility to malaria after prolonged lack of P. falciparum exposure...

Study of new malaria vaccine shows promise [Vaccine News] — (English)
Scientists from the National Institute of Allergy and Infectious Diseases (NIAID) announced on Monday improvements to an experimental vaccine designed to spur production of antibodies against the AMA1 malaria parasite protein ...