7.07.2014

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Announcements / Press Releases

Radical action to eliminate malaria in endemic zones [RBM/IOM press release and The Victoria Falls Declaration Ten Point Action Plan summary] — (English)
Ministers of Health from Malaria-Endemic Countries have adopted the Victoria Falls Declaration in which they commit to eliminate and expand malaria control to hard-to-reach migrant and mobile communities...

Malaria-Endemic Countries Unite to Extend Malaria Control to Hard-To-Reach Migrant and Mobile Communities [RBM/IOM] — (English)
Roll Back Malaria Partnership (RBM), together with the International Organization for Migration (IOM), has invited Ministers of Health from Southern Africa, Asia and other malaria-endemic regions, as well as the private sector to discuss the impact of migration on malaria control and elimination and address jointly the challenge of providing adequate health services to crossborder, mobile and migrant communities...

CAMA Workshop Proceeds with Full Partner Support [GBC] — (English)
The Federal Ministry of Health, the National Malaria Elimination Program and the Corporate Alliance on Malaria in Africa (CAMA) together with GBC Health, announce the 2014 Annual Technical Workshop, Capitalizing on Competencies: Partnering to Eliminate Malaria and Accelerate Impact on Maternal and Child Health on Wednesday, July 2nd at the Transcorp Hilton, Abuja, Nigeria...

Transforming Markets Saving Lives [UNITAID] — (English)
UNITAID Annual Report 2013...

MMV Director, Formulation Project Lead [MMV] — (English)
Reporting to the Head of Product Development, the Director will be responsible for successfully leading the strategy and implementation of technical development activities with the purpose of delivering new affordable antimalarial drugs in accordance with MMV’s mission...
Application deadline: 3.08.2014...


Senior Computational Statistician: Spatial Model [Malaria Atlas Project] — (English)
The Department of Zoology at the University of Oxford is looking for an experienced statistical modeller with skills in conceiving, implementing, and testing bespoke spatial statistical models on a 2-year fixed-term contract...
Application deadline: 16.07.2014...


Malaria Atlas Project: SEEG Data Archive Manager [Malaria Atlas Project] — (English)
The Data Archive Manager will be responsible for the management of the group’s spatiotemporal data archives, supporting this area of highly technical and interdisciplinary science...
Application deadline: 16.07.2014...


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6.07.2014

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Articles requiring subscription or registration

Malaria-induced changes in host odors enhance mosquito attraction [PNAS, Proceedings of the National Academy of Sciences] — (English)
We observed enhanced attraction of mosquitoes to mice infected by the rodent malaria parasite Plasmodium chabaudii during a key period after the subsidence of acute malaria symptoms but during which mice remained highly infectious...

Quantification of Plasmodium falciparum Histidine-Rich Protein-2 in Cerebral Spinal Fluid from Cerebral Malaria Patients [Am J Trop Med Hyg 2014 14-0210] — (English)
We examined the detection, semiquantification, and clinical use of the Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) as a parasite antigen biomarker for CM...s

Primaquine or other 8-aminoquinoline for reducing P. falciparum transmission [Cochrane Database Syst Rev. 2014 Jun 30;6:CD008152. doi: 10.1002/14651858.CD008152.pub3] — (English)
To assess whether giving PQ or an alternative 8AQ alongside treatment for P. falciparum malaria reduces malaria transmission, and to estimate the frequency of severe or haematological adverse events when PQ is given for this purpose...

High throughput ultra-sensitive molecular techniques to quantify low density malaria parasitaemias [JCM.01057-14] — (English)
To characterize the epidemiology of malaria in low transmission settings, and plan elimination strategies, more sensitive quantitative PCR is needed to identify and quantify low density malaria parasitaemias. A highly sensitive “high volume” quantitative PCR (qPCR) method based on Plasmodium sp 18sRNA was adapted for blood sample volumes of ≥250μL and scaled for high throughput...

Persistent oscillations and backward bifurcation in a malaria model with varying human and mosquito populations: implications for control [Journal of Mathematical Biology July 2014] — (English)
We derive and study a deterministic compartmental model for malaria transmission with varying human and mosquito populations...

Directional selection at the pfmdr1, pfcrt, pfubp1 and pfap2mu loci of Plasmodium falciparum in Kenyan children treated with ACT [J Infect Dis. (2014) doi: 10.1093/infdis/jiu358] — (English)
The efficacy of ACT for Plasmodium falciparum malaria may be threatened by parasites with reduced responsiveness to artemisinins. Among 298 ACT-treated children from Mbita, Kenya, sub-microscopic persistence of P. falciparum on day 3 post-treatment was associated with subsequent microscopically detected parasitaemia at days 28 or 4s...

Comparative study of Plasmodium falciparum erythrocyte membrane protein 1-DBLα domain variants with respect to antigenic variations and docking interaction analysis with glycosaminoglycans [Mol. BioSyst., 2014, DOI: 10.1039/C4MB00274A] — (English)
The variant surface antigen PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) encoded by the polymorphic multi-copy var gene family plays an important role in parasite biology and the host–parasite interactions. Sequestration and antigenic variation is an essential component in the survival and pathogenesis of Plasmodium falciparum and contributes to chronic infection. The DBLα domain of PfEMP1 is a potential target for immuno-epidemiological studies and has been visualized as a vaccine candidate against severe malaria...

Systemic and Cerebral Vascular Endothelial Growth Factor Levels Increase in Murine Cerebral Malaria along with Increased Calpain and Caspase Activity and Can be Reduced by Erythropoietin Treatment. [Front Immunol. 2014 Jun 19;5:291. doi: 10.3389/fimmu.2014.00291. eCollection 201] — (English)
We studied this pathway in mice infected with Plasmodium berghei ANKA causing murine CM with or without the use of erythropoietin (EPO) as adjunct therapy. ELISA and western blotting was used for quantification of VEGF and relevant proteins in brain and plasma. CM increased levels of VEGF in brain and plasma and decreased plasma levels of soluble VEGF receptor 2. EPO treatment normalized VEGF receptor 2 levels and reduced brain VEGF levels...

Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection [Traffic DOI: 10.1111/tra.12190] — (English)
Here, we dissected the interaction between the Plasmodium parasite and the host cell late endocytic pathway and show that parasite growth is dependent on the phosphoinositide 5-kinase (PIKfyve), which converts phosphatidylinositol 3-phosphate [PI(3)P] into phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] in the endosomal system...

Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System [American Society for Microbiology] — (English)
Our results establish methodologies for introducing desired modifications in the P. yoelii genome with high efficiency and accuracy, which will greatly improve our ability to study gene function of malaria parasitess...