28.07.2014

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Announcements / Press Releases

Country and Community Consultation Toolkit for GMAP2 now available [RBM] — (English)
The process of country consultations for the 2nd Global Malaria Action Plan is moving ahead and consultations have now been held in Myanmar, Democratic Republic of the Congo, India and the Philippines. The in-country process starts off by talking with affected communities, community development workers, first line health workers, district and regional staff. The views of these key stakeholders are put at the centre of national level consultations that involve a broad multisectoral audience including civil society, the private sector, academia, donors and Government representatives from different sectors and levels.
Access the toolkit of materials for arranging a consultation and participate in the process of creating the GMAP2 document. The toolkit is available in French, Spanish and Portuguese as well as in English...
[More info in French]


WHO procedures for certification of malaria elimination [WHO Weekly epidemiological record] — (English)
Certification of malaria elimination is the official recognition of malaria-free status granted by WHO...

Ban Ki-moon launches 2014 MDG report [UN] — (English)
UN Secretary General Ban Ki-moon launched the latest progress report on the Millennium Development Goals. While many of the targets have been met, including target 6C on malaria, significant challenges remain. Read the report...

Vice-Chair of the Board Supports New Funding Model in Laos [The Global Fund] — (English)
In early July, the Vice-Chair of the Board of the Global Fund, Mireille Guigaz, met with various representatives of the fight against the three diseases in Laos, drawing lessons from the implementation of the new funding model and from the effectiveness of country dialogue to include the voices of all in-country stakeholders...

One route to malaria drug resistance found [Washington University School of Medicine] — (English)
Researchers have uncovered a way the malaria parasite becomes resistant to an investigational drug. The discovery, at Washington University School of Medicine in St. Louis,...

AMP Conference Call Minutes [AMP] — (English)
See the latest AMP call minutes....

Global Fund News Flash: Issue 46 [The Global Fund] — (English)
A Conference with Emotion et al....

MMV: Pharmaceutical Technical Development/CMC Leader [MMV] — (English)
Reporting to the Head of Product Development, the Pharmaceutical Technical Development/CMC Leader will be responsible for successfully leading the strategy and implementation of technical development activities with the purpose of delivering new affordable antimalarial drugs in accordance with MMV’s mission...
Application deadline: 3.08.2014...


Medical Director [MMV] — (English)
Reporting to the Chief Medical Officer, the Medical Director will lead medical activities on translational and development projects, which includes contributing to the clinical development strategy, reviewing and validating documents according to safety regulations, as well as reviewing data and reports...
Application deadline: 3.08.2014...


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Articles requiring subscription or registration

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990—2013: a systematic analysis for the Global Burden of Disease Study 2013 [The Lancet, doi:10.1016/S0140-6736(14)60844-8] — (English)
Our estimates of the number of people living with HIV are 18·7% smaller than UNAIDS's estimates in 2012. The number of people living with malaria is larger than estimated by WHO. The number of people living with HIV, tuberculosis, or malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths have been reversed and declines in tuberculosis deaths have accelerated. 101 countries (74 of which are developing) still have increasing HIV incidence. Substantial progress since the Millennium Declaration is an encouraging sign of the effect of global action...

Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum [Nature Communications 5, Article number: 4446 doi:10.1038/ncomms5446] — (English)
Here, using an in vitro parasite culture system with erythrocytes from iron-deficient and replete human donors, we demonstrate that Plasmodium falciparum infects iron-deficient erythrocytes less efficiently. In addition, owing to merozoite preference for young erythrocytes, iron supplementation of iron-deficient individuals reverses the protective effects of iron deficiency...

A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites [Nature Communications 5, Article number: 4467 doi:10.1038/ncomms5467] — (English)
ecause ​PfHAD1 has homologues in plants and bacteria, other HAD proteins may be MEP pathway regulators...

PGMS: A Case Study of Collecting PDA-Based Geo-Tagged Malaria-Related Survey Data [Am J Trop Med Hyg 2014 13-0652] — (English)
This case study seeks to design a generic survey framework PDA-based geo-tagged malaria-related data collection tool (PGMS) that can be used not only for large-scale community-level geo-tagged electronic malaria-related surveys, but also for a wide variety of electronic data collections of other infectious diseases...

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine [Am J Trop Med Hyg 2014 14-0031] — (English)
Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine...

Effect of co-administered fat on the tolerability, safety and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria [AAC.03314-14] — (English)
Co-administration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity...

Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat Province, Western Cambodia [AAC.03026-14] — (English)
Here we show that CQ effectively treats P. vivax malaria in Pursat Province, Western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading...

Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug resistant Plasmodium falciparum isolates from Cambodia [AAC.02462-14] — (English)
We conducted blinded ex vivo activity testing of fully synthetic (OZ78, OZ277) and semi-synthetic endoperoxides (artemisone, artemiside, artesunate, dihydroartemisinin) in the histidine-rich protein 2 ELISA against 200 P. falciparum isolates from areas of artemisinin-resistant malaria in western and northern Cambodia in 2009/10...

Diagnosing malaria infected cells at the single cell level using focal plane array Fourier transform infrared imaging spectroscopy [Analyst. 2014 Jul ] — (English)
This work demonstrates the potential of focal plane technology to diagnose single cells in a blood smear...

False positive results for malaria rapid diagnostic tests in patients with rheumatoid factor [JCM 10.1128/JCM.01797-14] — (English)
The false positive rate ranged from 2.2% to 13% in RF-positive patients. High RF levels are associated with false-positivity of malaria RDTs...

Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology [mcp.M114.040956] — (English)
To better our understanding of gametocyte development and subsequent infectiousness to mosquitoes, we undertook a Systematic Subtractive Bioinformatic analysis (filtering) approach to identify sex-specific P. falciparum NF54 protein markers based on a comparison with the Dd2 strain, which is defective in producing males, and with syntenic male and female proteins from the reanalyzed and updated P. berghei (related rodent malaria parasite) gametocyte proteomes...

Testosterone persistently dysregulates hepatic expression of Tlr6 and Tlr8 induced by Plasmodium chabaudi malaria [Parasitology Research July 2014] — (English)
Here, we investigate effects of T and P. chabaudi on mRNA expression and promoter DNA methylation of Tlr1–9 genes in the liver of female C57BL/6 mice...

Educating the security forces, a high risk group in malaria elimination efforts: an example from Sri Lanka [Int. Health (2014) doi: 10.1093/inthealth/ihu044] — (English)
The objective of the study was to develop a prototype educational programme on malaria for security forces serving in endemic areas...

The Effect of Immunodeficiency on the Evolution of Virulence: An Experimental Test with the Rodent Malaria Plasmodium chabaudi [The American Naturalist Vol. 184, No. S1, August 2014] — (English)
Here, we use serial passage experiments in mice to test how immune-suppressed hosts may alter pathogen virulence evolution...