11.08.2014

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Announcements / Press Releases

Roll Back Malaria Partnership - Development of a Programme Management Tool [RBM] — (English)
Submission deadline: 21 August 2014 12 midnight CET

Leadership interview with Akudo Anyanwu Ikemba [RBM] — (English)
Akudo Anyanwu Ikemba is an award-winning global health expert, public health innovator and social entrepreneur with over 15 years of experience in the field of international development. She is Founder and Chief Executive Officer of Friends Africa, a pan-African organization that fights AIDS, tuberculosis and malaria by mobilizing African businesses, governments and NGOs. She also serves on the boards of Roll Back Malaria, the Global Health Council and the AIDS Healthcare Foundation...

The RBM Partnership congratulates Dr Pedro Alonso and Mr Lelio Marmora on their new appointments [RBM] — (English)
The RBM Partnership welcomes the WHO Director General's recent nomination of Dr Pedro L. Alonso as Director of the Global Malaria Programme and Mr Lelio Marmora as UNITAID Executive Director...

Molecular map inside malaria parasite could lead to new antimalarial drugs [ICL] — (English)
Imperial scientists have gained unique structural insights into the production line of parasite proteins that cause malaria...

An easier way to manipulate malaria genes [MIT] — (English)
New approach to knocking out parasite’s genes could make it easier to identify drug targets...

Global Fund Welcomes Germany’s Increased Contribution [The Global Fund] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria warmly welcomed a decision by the German parliament to increase Germany's contribution to €245 million for 2014 in the budget for this year, reaffirming a strong commitment to global health...

PMI.gov Has a New Look! [PMI] — (English)
PMI.gov has been completely redesigned. Come explore what’s new and learn more about some of our features, such as PMI’s searchable library of reports, guidance, contracts, and more. Learn more about the cross-cutting technical areas in the fight against malaria or view all of the PMI resources specific to any of the PMI focus countries...

WHO Consultancy opportunities [WHO/GMP] — (English)
The Geneva-based RAcE project team is seeking the services of a communication consultant to develop a communications and information dissemination strategy, provide advice on strategic and programmatic communications issues, and increase the visibility of the project in implementation countries, regionally and globally...

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Articles requiring subscription or registration

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria [The New England Journal of Medicine] — (English)
Artemisinin resistance to P. falciparum, which is now prevalent across mainland Southeast Asia, is associated with mutations in kelch13. Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing...

An Evaluation of Methods for Assessing the Quality of Case Management for Inpatients with Malaria in Benin [Am J Trop Med Hyg 2014 vol. 91 no. 2 354-360 ] — (English)
We employed three methods in five hospitals to assess 11 signs of malaria and severe disease...

Preliminary Investigation of the Contribution of CYP2A6, CYP2B6, and UGT1A9 Polymorphisms on Artesunate-Mefloquine Treatment Response in Burmese Patients with Plasmodium falciparum Malaria [Am J Trop Med Hyg 2014 vol. 91 no. 2 361-366] — (English)
CYP2A6, CYP2B6, and UGT1A9 genetic polymorphisms and treatment response after a three-day course of artesunate-mefloquine was investigated in 71 Burmese patients with uncomplicated Plasmodium falciparum malaria

Placental Malaria is Rare Among Zanzibari Pregnant Women who did not Receive Intermittent Preventive Treatment in Pregnancy [Am J Trop Med Hyg 2014 vol. 91 no. 2 367-373 ] — (English)
It may be reasonable for the Ministry of Health to consider discontinuing IPTp, intensifying surveillance efforts, and promoting insecticide-treated nets and effective case management of malaria in pregnancy

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine [eLife] — (English)
We have solved the cryo-EM structure of the cytoplasmic ribosome from the human malaria parasite, Plasmodium falciparum, in complex with emetine at 3.2 Å resolution...

The Historical Distribution of Main Malaria Foci in Spain as Related to Water Bodies [Int. J. Environ. Res. Public Health 2014, 11(8), 7896-7917; doi:10.3390/ijerph110807896] — (English)
This study combines, by means of a spatial-temporal analysis, the historical data of patients and deceased with the distribution of water bodies where the disease-transmitting mosquitos proliferate...

Baculovirus-Vectored Multistage Plasmodium vivax Vaccine Induces Both Protective and Transmission-blocking Immunities against Transgenic Rodent Malaria Parasites [IAI.02040-14] — (English)
Here, we describe the development of a multistage Plasmodium vivax vaccine, which simultaneously expresses circumsporozoite protein (PvCSP) and P25 (Pvs25) protein of this species as a fusion protein, thereby acting as a pre-erythrocytic and TB vaccine, respectively...

Potential immune mechanisms associated with anemia in Plasmodium vivax malaria: a puzzling question [IAI.01972-14] — (English)
In this review we consider potential immune effectors and their possible involvement in generating this clinical outcome during P. vivax infections

Interspecies allometric scaling of antimalarial drugs and potential application to pediatric dosing [AAC.02538-14] — (English)
We investigated the allometric scaling relationships of antimalarial drugs using data from pharmacokinetic studies in mammalian species...

Culminating anti-malaria efforts at long lasting insecticidal net? [Journal of Infection and Public Health] — (English)
Focused research on developing effective anti-malarial drugs, vaccines and new insecticides to reduce resistance is imperative to tackle malaria in the future...

Interactive transcriptome analysis of malaria patients and infecting Plasmodium falciparum [Genome Res. 2014] — (English)
Here we report the RNA-seq analysis of 116 Indonesian patients infected with the malaria parasite Plasmodium falciparum (Pf)...

Here we report the RNA-seq analysis of 116 Indonesian patients infected with the malaria parasite Plasmodium falciparum (Pf) [Int. Health (2014) doi: 10.1093/inthealth/ihu047] — (English)
A qualitative study was carried out to explore malarial lay perceptions and therapeutic itinerary among 30 resettled pregnant women in Unity State, South Sudan...

The potent Anti-malarial activity of Acriflavine in vitro and in vivo [ACS Chem. Biol., Just Accepted Manuscript DOI: 10.1021/cb500476q] — (English)
We thus establish ACF as a potential antimalarial amidst the widespread incidence of drug resistant Plasmodium strains...

Towards malaria microscopy at the point-of-contact: an assessment of the diagnostic performance of the Newton Nm1 microscope in Uganda [arasitology / FirstView Article pp 1-7] — (English)
Malaria microscopy in sub-Saharan Africa is often restricted by access to light microscopes. To address this gap, a novel portable inverted monocular microscope, the Newton Nm1, was designed and is now commercially available...