25.08.2014

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Announcements / Press Releases

15th East Africa Sub-Regional Network (EARN) Annual Meeting General Assembly meeting, Kigali, RWANDA, 15-19 September 2014 [RBM] — (English)
Background documents

Rélunion annuélle de revue et planification des activités de lutte contre le paludisme en Afrique Centrale, 11,12,13 Septembre 2014 à Libreville/GABON [RBM] — (English)
DRAFT meeting agenda

Strengthening National Climate Data and Information for Malaria Decision Making in Africa [RBM Partnership] — (English)
Meeting report

Continuous LLIN Distribution Lessons in Brief No. 11 [RBM] — (English)
Ghana’s mixed model scores coverage points [in French]

AMP Conference Call Minutes [AMP] — (English)
July issues...

WHO Consultancy opportunities [WHO/GMP] — (English)
The Geneva-based RAcE project team is seeking the services of a communication consultant to develop a communications and information dissemination strategy, provide advice on strategic and programmatic communications issues, and increase the visibility of the project in implementation countries, regionally and globally...

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Articles requiring subscription or registration

A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial) [BMJ Open 2014;4:e006005 doi:10.1136/bmjopen-2014-006005] — (English)
Malaysia's national policy for malaria pre-elimination involves mandatory hospital admission for confirmed malaria cases with discharge only after two negative blood films; use of a more rapidly acting antimalarial agent would have health cost benefits. P. knowlesi is commonly microscopically misreported as P. malariae, P. falciparum or P. vivax, with a high proportion of the latter two species being chloroquine-resistant in Malaysia. A unified ACT-treatment protocol would provide effective blood stage malaria treatment for all Plasmodium species

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies [Nature (2014) doi:10.1038/nature13715] — (English)
Here we present crystal structures of PfRH5 in complex with basigin and two distinct inhibitory antibodies

Identification of Essential Histidine Residues Involved in Heme Binding and Hemozoin Formation in Heme Detoxification Protein from Plasmodium falciparum [Scientific Reports 4, Article number: 6137 doi:10.1038/srep06137] — (English)
We identified the active site residues in HDP using a combination of Hz formation assay and spectroscopic characterization of mutant proteins

s Quantitation of Malaria Parasite-Erythrocyte Cell-Cell Interactions Using Optical Tweezers [Biophzsical Journal Volume 107, Issue 4, 19 August 2014, Pages 846–853] — (English)
Here we employ optical tweezers to study individual invasion events for what we believe is the first time, showing that newly released P. falciparum merozoites, delivered via optical tweezers to a target erythrocyte, retain their ability to invade

Export of virulence proteins by malaria-infected erythrocytes involves remodelling of host actin cytoskeleton [Blood] — (English)
Following invasion of human red blood cells (RBC) by the malaria parasite, Plasmodium falciparum, a remarkable process of remodelling occurs in the host cell mediated by trafficking of several hundred effector proteins to the RBC compartment. The exported virulence protein, P. falciparum erythrocyte membrane protein 1 (PfEMP1), is responsible for cytoadherence of infected cells to host endothelial receptors

Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles [International Journal of Nanomedicine » Volume 9 » Issue 1] — (English)
The aim of this work was to design, synthesize, and characterize PQ-loaded solid lipid nanoparticles (SLNs) (PQ-SLNs) as a potential drug-delivery system

Inducing Effect of Dihydroartemisinic Acid in the Biosynthesis of Artemisinins with Cultured Cells of Artemisia annua by Enhancing the Expression of Genes [The Scientific World Journal Volume 2014 (2014), Article ID 293190] — (English)
At the current paper, the biosynthesis of artemisinin (ART) and its four analogs from dihydroartemisinic acid (DHAA) in suspension-cultured cells of Artemisia annua were investigated...