25.08.2014

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Announcements / Press Releases

RBM deploys staff to Ebola-stricken countries on a fact-finding mission [RBM] — (English)
As fragile healthcare systems in Guinea, Liberia, Nigeria and Sierra Leone struggle with one of the largest Ebola outbreaks in history, the Roll Back Malaria Partnership has mobilised its global Secretariat to support efforts to restore the provision of essential health services in the affected countries...

UNICEF distributes half a million mosquito nets amid heavy rains and violence in CAR [UNICEF press release] — (English)
Amid heavy rains and violence UNICEF and partners have distributed more than half a million mosquito bed nets reaching every home in Bangui to protect families from malaria - the leading killer of children under 5 in Central African Republic...

Drug Prevents Malaria in High-Risk Region [NIH Research Matters] — (English)
A combination drug treatment substantially reduced the incidence of malaria in young children without causing serious side effects...

2014 CCoP Meeting Report [RBM CCoP] — (English)
On May 12-13, 2014, the first Roll Back Malaria (RBM) Communication Community of Practice (CCoP) Annual Partners Meeting convened in Geneva, Switzerland...

16th MIP Working Group meeting [RBM] — (English)
Meeting report and presentations...

Strengthening National Climate Data and Information for Malaria Decision Making in Africa [RBM Partnership] — (English)
Meeting report

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Articles requiring subscription or registration

Loss and dysfunction of Vδ2+ γδ T cells are associated with clinical tolerance to malaria [Sci. Transl. Med. DOI: 10.1126/scitranslmed.3009793] — (English)
We found that repeated malaria was associated with reduced percentages of Vδ2+ γδ T cells in peripheral blood, decreased proliferation and cytokine production in response to malaria antigens, and increased expression of immunoregulatory genes...

Venezuela's failure in malaria control [The Lancet, Volume 384, Issue 9944, Pages 663 - 664, 23 August 2014 doi:10.1016/S0140-6736(14)61389-1] — (English)
In their recent Correspondence (June 7, p 1967),1 José Félix Oletta and colleagues noted that in the past 15 years the Venezuelan Government has been incapable of implementing a coherent plan to address the health needs of its people, and importantly, failed in the control of vector-borne diseases such as malaria and dengue...

Individual and household factors associated with use of insecticide treated nets in southern Ethiopia [Trans R Soc Trop Med Hyg (2014) doi: 10.1093/trstmh/tru129] — (English)
We studied individual and household factors associated with LLIN use in Halaba district in southern Ethiopia...

Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health in The Gambia, Burkina Faso and Benin: study protocol for a randomized controlled trial [Trials 2014, 15:340 doi:10.1186/1745-6215-15-340] — (English)
The primary objective is to determine the protective efficacy of community-scheduled screening and treatment (CSST) using community health workers (CHW) against the primary outcome of prevalence of placental malaria. The secondary objectives are to determine the protective efficacy of CSST on maternal anaemia, maternal peripheral infection, low birth weight, selection of sulfadoxine-pyrimethamine (SP) resistance markers, and on antenatal clinic (ANC) attendance and coverage of intermittent preventive treatment during pregnancy (IPTp-SP)...

In Vivo Antiplasmodial Potentials of the Combinations of Four Nigerian Antimalarial Plants [Molecules 2014, 19(9), 13136-13146; doi:10.3390/molecules190913136] — (English)
Various combinations of Nauclea latifolia root, Artocarpus altilis stem bark, Murraya koenigii leaf and Enantia chlorantha stem bark used in African ethnomedicine as decoctions for malaria and fevers, and combinations with standard drugs, were investigated for antiplasmodial activities using Plasmodium berghei berghei-infected mice...

Analyse descriptive du paludisme à Plasmodium falciparum dans une communauté expatriée à Yaoundé-Cameroun [Bulletin de la Société de pathologie exotique August 2014] — (English)
This study confirms the presence of urban malaria in Yaounde and the need to adopt measures including prophylaxis...

Antigen reversal identifies the targets of opsonizing IgGs against pregnancy-associated malaria [IAI.02097-14] — (English)
Our study introduces a new approach to determining the antigenic targets of opsonizing IgGs in phagocytosis assays...

Damage to the blood-brain barrier during experimental cerebral malaria results from the synergistic effects of CD8+ T cells with different specificities [IAI.02180-14] — (English)
The tools that we developed can be used to further investigate the heterogeneity of CD8+ T cell responses that are involved in ECM...

The sub-cellular location of OVA in Plasmodium blood stages influences the magnitude of T-cell responses [IAI.01940-14] — (English)
These results indicate that unconjugated cytosolic OVA is not stably expressed in Plasmodium parasites and, importantly, its cellular location and expression level influence both the induction and magnitude of parasite-specific T-cell responses. These parasites represent useful tools to study the development and function of antigen-specific T-cell responses during malaria infection...

Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea [AAC.03323-14] — (English)
The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and vivax...

An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission [Cellular Microbiology] — (English)
We show that Plasmodium berghei sas6 knockouts display severely abnormal male gametogenesis presenting reduced basal body numbers, axonemal assembly defects and abnormal nuclear allocation...