22.09.2014

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Announcements / Press Releases

Advocacy for Resource Mobilization Workshop [RBM] — (English)
The Ministry of Health of Gabon, with the support of the Roll Back Malaria Partnership Malaria Advocacy Working Group (MAWG) and the Sub Regional Network for Central Africa (CARN), organized a three-day workshop on advocacy for resource mobilization for the national fight against malaria in Libreville from September 15 to 17, 2014...

Sixty-seventh Session of the Regional Committee [WHO SEARO] — (English)
Ministers of Health in the WHO South-East Asia Region adopted the Dhaka Declaration on Vector-borne Diseases on 9 September, pledging to intensify vector control efforts and strengthen the overall capacity of health systems to respond to these threats. The ministers emphasized the need to improve surveillance systems, apply a “health in all policies” approach, and mobilize adequate financial and human resources to accelerate the regional effort. They also called for a ban on the use of oral artemisinin-based monotherapies for the treatment of P. falciparum malaria...

Policy brief on malaria diagnostics in low-transmission settings [WHO/HTM/GMP/2014.7] — (English)
This policy brief provides a list of recommendations on the role, characteristics, performance and applications of these molecular diagnostic tests for malaria in low-transmission areas...

Global Fund Congratulates DFID on Winning International Procurement Award [The Global Fund] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria congratulated the UK Department for International Development (DFID) on the award of Best Contribution to the Reputation of the Procurement Profession it won last week...

UCSF, Google Earth Engine Making Maps to Predict Malaria [UCSF] — (English)
UC San Francisco (UCSF) is working to create an online platform that health workers around the world can use to predict where malaria is likely to be transmitted using data on Google Earth Engine...

Sumitomo Chemical Announces Breakthrough in the Development of a New Mode of Action Insecticide for Adult Mosquito Control [Sumitomo Chemical] — (English)
Sumitomo Chemical is very pleased to announce the development and recent submission to WHOPES of a new mode of action insecticide product for adult mosquito control for application in IRS programs...

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Articles requiring subscription or registration

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(14)70855-2] — (English)
Heterogeneity of study design and analysis has confounded global surveillance of chloroquine-resistant P vivax, which is now present across most countries endemic for P vivax. Improved methods for monitoring of drug resistance are needed to inform antimalarial policy in these regions...

Male motion coordination in anopheline mating swarms [Scientific Reports 4, Article number: 6318 doi:10.1038/srep06318] — (English)
The authors identify frequent, time-varying interactions characterized by periods of parallel flight in data from 8 swarms of Anopheles gambiae and 3 swarms of Anopheles coluzzii filmed in 2010 and 2011 in the village of Donéguébogou, Mali...

Monitoring parasite diversity for malaria elimination in sub-Saharan Africa [Science, Vol. 345 no. 6202 pp. 1297-1298 DOI: 10.1126/science.1259423] — (English)
The study describes the Plasmodium Diversity Network Africa (PDNA), which has been established across 11 countries in sub-Saharan Africa to ensure that African scientists are enabled to work together and to play a key role in the global effort for tracking and responding to this public health threat...

Zambia fights to sustain its malaria success [Science, Vol. 345 no. 6202 pp. 1270-1271 DOI: 10.1126/science.345.6202.1270] — (English)
A model for malaria interventions is at risk as funding flattens and the disease smolders on...

Severe Malaria [Tropical Medicine & International Health Special Issue: Severe Malaria Volume 19, Issue Supplement s1, pages 7–131, September 2014] — (English)
Section 1: Epidemiology of severe falciparum malaria...

Optimal Seasonal Timing of Oral Azithromycin for Malaria [Am J Trop Med Hyg 2014 13-0474] — (English)
The authors conclude that when azithromycin-based trachoma elimination programs occur in regions of seasonal malaria transmission, such as Niger, the optimal seasonal timing of mass drug administration may not occur during the season of maximum transmission...

Malaria diagnostics: now and the future [Parasitology] — (English)
This paper reviews the main in vitro methods for parasite detection and considers future trends in diagnostics, both for sophisticated laboratory settings and for field use...

Organisation and function of an actin cytoskeleton in Plasmodium falciparum gametocytes [Cellular Microbiology] — (English)
The study describes a previously unrecognised actin-based cytoskeleton that is assembled in maturing P. falciparum gametocytes...

Characterization of Plasmodium Developmental Transcriptomes in Anopheles gambiae midgut Reveals Novel Regulators of Malaria Transmission [Cellular Microbiology] — (English)
The authors used DNA microarrays to profile the developmental transcriptomes of the rodent malaria parasite Plasmodium berghei in vivo, in the midgut of Anopheles gambiae mosquitoes, from parasite stages in the midgut blood bolus to sporulating oocysts on the basal gut wall...

Autoimmunity, phospholipid-reacting antibodies and malaria immunity [Lupus. 2014 Oct;23(12):1295-8. doi: 10.1177/0961203314546021] — (English)
The article provides an overview of studies conducted in our laboratory that shed some light on the questions of whether antiphospholipid antibodies (aPL) and other AAb associated with autoimmune diseases (AID) can recognize Plasmodia antigens and exert anti-parasite activity; and whether anti-parasite phospholipid antibodies, produced in response to malaria, can inhibit phospholipid-induced inflammatory responses and protect against the pathogenesis of severe malaria...

High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria [Clin Infect Dis. (2014) doi: 10.1093/cid/ciu735] — (English)
High endogenous plasma EPO levels are associated with prolonged coma duration and increased mortality in children above 18 months of age with CM...

Delayed parasite clearance after treatment with dihydroartemisinin-piperaquine in Plasmodium falciparum malaria patients in Central Vietnam [AAC.02746-14] — (English)
Following increasing reports from central Vietnam of delayed parasite clearance after treatment with dihydroartemisinin-piperaquine (DHA-PPQ), the current first line treatment, a study on the efficacy of this treatment was carried out...

Molecular-based isothermal tests for field diagnosis of malaria and their potential contribution to malaria elimination [J. Antimicrob. Chemother. (2014) doi: 10.1093/jac/dku343] — (English)
The present review describes LAMP and several other isothermal nucleic acid amplification methods, such as thermophilic helicase-dependent amplification, strand displacement amplification, recombinase polymerase amplification and nucleic acid sequence-based amplification, and explores their potential use as high-throughput, field-based molecular tests for malaria diagnosis...

Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity [Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1313-24. doi: 10.1517/17425255.2014.954547] — (English)
This paper focuses on physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid shown to have antimalarial activity against chloroquine-resistant P. falciparum. The aim is to identify potential liabilities that could arise from covalently linking two pharmacophoric units of different drug classes into one functional drug...

Isoprenoid Biosynthesis in Plasmodium falciparum [EC.00160-14] — (English)
The authors outline what is known about isoprenoid function and regulation of isoprenoid synthesis in P. falciparum, in order to identify valuable directions for future research...

Parallel evolution or purifying selection, not introgression, explains similarity in the pyrethroid detoxification linked GSTE4 of Anopheles gambiae and An. arabiensis [Molecular Genetics and Genomics] — (English)
The demonstration of a role for an up-regulated gene in metabolic resistance to insecticides should not be limited to simply whether it can metabolise insecticide; such a strict criterion would argue against the involvement of GSTE4 despite the weight of evidence to the contrary...

Reduction of incidence and relapse or recrudescence cases of malaria in the western region of the Brazilian Amazon [JIDC] — (English)
This study evaluated the epidemiological profile of malaria in Rondônia between 2008 and 2012...