02.10.2014

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Dear Subscribers of Malaria in the News and RBM eNewsletter,
This is the last issue of Malaria in the News designed, compiled and edited by me. I would like to use this opportunity to express my gratitude to you all for your interest and support.
Regards,
Marina Gavrioushkina


Business Leaders and Health Experts Gather in Yangon for First Regional Meeting on Corporate Sector Engagement in Malaria Control in the Asia-Pacific [RBM] — (English)
More than 100 leaders from the health, development and corporate sectors have gathered in Yangon to participate in the seminal regional forum on Opportunities for Corporate Sector Engagement in Malaria Control in the Asia-Pacific. In advance of the 2015 enactment of the ASEAN Free Trade Agreement and broader ASEAN economic integration, this one-day meeting seeks to identify tangible opportunities for strengthened public-private partnerships to support regional malaria control strategies and drive progress toward country-specific development targets...

Statement from Dr Fatoumata Nafo Traoré on the occasion of the United Nations General Assembly [RBM] — (English)
The MDGs were good for malaria control, says RBM Executive Director at launch of a new UN report<...

Luxembourg Raises Contribution to the Global Fund [The Global Fund] — (English)
Luxembourg is increasing its financial commitment to the Global Fund for 2014, thereby unlocking additional contributions from the United States and the United Kingdom...

Major Push for Domestic Financing for Health [The Global Fund] — (English)
A passionate call for low and middle income countries to increase their spending on health was launched by Kenyan President Uhuru Kenyatta at the United Nations General Assembly on Monday evening...

Ecobank Expands Partnership with Global Fund [The Global Fund] — (English)
Ecobank Group and the Global Fund to Fight AIDS, Tuberculosis and Malaria are expanding a partnership to include South Sudan after collaborating since 2011 on capacity-building programs for Global Fund implementers in Cote d’Ivoire and Nigeria...

News from TDR Director [TDR] — (English)
Thirty-nine people from 23 countries have received funding to advance their research careers...

Evaluating antimalarial safety [ACT Consortium] — (English)
ACT Consortium interactive webinar on the safety of artemisinin-based combination therapies (ACTs) will take place Tuesday 7 October 12:30 - 2:00 pm BST (UK time)...

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Articles requiring subscription or registration

Efficacy of Artemisinin-Based Combination Treatments of Uncomplicated Falciparum Malaria in Under-Five-Year-Old Nigerian Children [Am J Trop Med Hyg 2014 13-0248] — (English)
The efficacy of 3-day regimens of artemether-lumefantrine and artesunate-amodiaquine were evaluated in 747 children...

Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomised controlled trial in Burkina Faso [J Infect Dis. (2014) doi: 10.1093/infdis/jiu540] — (English)
The combination of MB with an ACT has been confirmed to be effective against the gametocytes of P. falciparum. MB-based combinations need to be compared to primaquine-based combinations, preferably using MB in an improved pediatric formulation...

Desiccation tolerance as a function of age, sex, humidity and temperature in adults of the African malaria vectors Anopheles arabiensis Patton and Anopheles funestus Giles [JEB doi: 10.1242/​jeb.104638] — (English)
An. arabiensis is often considered to be the more arid-adapted of the two species, it showed lower survival times and higher water loss rates than An. funestus...

Immunization of mice with live-attenuated late liver stage-arresting P. yoelii parasites generates protective antibody responses to pre-erythrocytic stages of malaria [IAI doi: 10.1128/IAI.02320-14] — (English)
The study demonstrates for the first time that antibodies induced by experimental immunization of mice with a genetically attenuated rodent parasite play a protective role during the pre-erythrocytic stages of malaria...

Effect of fluorescent dyes on in-vitro differentiated, late-stage Plasmodium falciparum gametocytes [AAC.03772-14] — (English)
Gametocytocidal activity of nine synthetic dyes and four compounds with known activity was tested against stage V gametocytes of the laboratory strain 3D7 and three clinical isolates of P. falciparum with a bioluminescence assay...

A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs [AAC.03666-14] — (English)
The authors show compound activity in the Pf DGFA accurately predicts activity in Pf SMFAs, which validates and supports its adoption into the transmission-stage screening pipeline...

Gazing at the Crystal Rods of Malaria [doi: 10.1373/clinchem.2013.218248 Clinical Chemistr] — (English)
Hemozoin, the black–brown crystalline byproduct from a parasite's digestion of hemoglobin, aided the detection of malaria over a century ago when Ronald Ross won a Nobel Prize for his discovery of the transmission of malari...

Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents [Molecules 2014, 19(9), 15237-15257; doi:10.3390/molecules190915237] — (English)
This report describes the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains)...

Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients [J. Antimicrob. Chemother. (2014) doi: 10.1093/jac/dku358] — (English)
The presence of pseudogenes, although unlikely to have any direct public health impact, may confound results obtained from simple genotyping methods that consider only codon 76 and the adjacent residues of pfcrt...

Cerebral malaria with diffuse subcortical microhaemorrhages and a transient splenial lesion [Acta Neurologica Belgica] — (English)
Case report...