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Artemisinin-based combination therapies (ACTs)

  • Overview
  • Procurement of ACTs
  • Artemisia
Photo by Bonnie Gillespie, Johns Hopkins University

The following ACTs are currently recommended by WHO for the treatment of uncomplicated falciparum malaria (alphabetical order):

  1. artemether-lumefantrine,
  2. artesunate + amodiaquine,
  3. artesunate + mefloquine,
  4. artesunate + sulfadoxine–pyrimethamine,
  5. dihydroartemisinin + piperaquine,
  6. artesunate + pyronaridine tetraphosphate .

Links & resources:

Procurement of Artemisinin-based Combination Therapies (ACTs)

Artemisinin-based Combination Therapies (ACTs) are today's most effective anti-malarial treatments. In the tables below, manufacturers' contact information is presented under "Administrative data", and specifications of their products under "Technical data". These tables present only medicines which have been WHO prequalified or which are mentioned in WHO procurement information, in which there are medicines procured by WHO and UNICEF on the basis of the review of individual product dossiers and successful inspection of manufacturing sites in accordance with Good Manufacturing Practices (GMP). Some prequalified medicines are not mentioned in the WHO procurement information, because they are no longer recommended for the treatment of malaria.

ACTs: Manufacturer contact details

ACTs: Product information

ACTs: Logistical data


Related materials

Good procurement practices for artemisinin-based antimalarial medicines
WHO, 2010
[in English] [in French]

Seasonal Malaria Chemoprevention with Sulfadoxine-Pyrimethamine plus Amodiaquine in ChildrenSeasonal Malaria Chemoprevention with Sulfadoxine-Pyrimethamine plus Amodiaquine in Children
WHO, 2013
[in English] [in French]

Guidelines for the treatment of malariaGuidelines for the treatment of malaria
2010 [in English] [in French]

Manual for quantification of Malaria CommoditiesManual for quantification of Malaria Commodities
2012 [in English] [in French]

Guide to the Global Fund's Policies on Procurement and Supply ManagementGuide to the Global Fund's Policies on Procurement and Supply Management
The Global Fund, June 2012
[in English] [in French]

Management of severe malaria – A practical handbook. Third editionManagement of severe malaria – A practical handbook. Third edition
WHO 2013
[in English] [in French]

Artemisinin Enterprise: 3 complementary scientific projects that aim to improve artemisinin production technologies and reduce the price of ACTs to patients

Comparative Assessment of Technologies for Extraction of Artemisinin
A summary of report commissioned through Malaria Medicines Ventures (MMV)
Malcolm Cutler, Alexei Lapkin and Pawel K. Plucinski
August 2006 [in English]

Artemisia, Agriculture and Malaria in Africa:
The Interplay of Tradition, Science and Public Policy
A working paper by Dana G. Dalrymple
3rd edition 2012 [in English]

The world of Artemisia in 44 questions
The Royal Tropical Institute
Willem Heemskerk, Henk Schallig, Bart de Steenhuijsen Piters
March 2006 [in English]